The Institute of Scientific and Industrial Research, Osaka University

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Department of Organic Fine Chemicals

Staff

  • Photo
    Assis. Prof.
    Y. HIGUCHI
  • Photo
    Specially Appointed Assoc. Prof.
    K. KAIHATSU

Content of research

Based on chemical proteomic approaches, our research interests are focused on the rational design and synthesis of small organic compounds that potentially modulate/inhibit protein-protein interactions. These compounds are also utilized as a tool in our chemical genomic study to elucidate intracellular signaling pathways. Our research also extends into the development of a novel type of nucleobase that can specifically recognize virus genome sequence.

Current Research Programs

  1. 1. Drug discovery based on controlling intracellular signal transductions by low-molecular-weight compounds.
  2. 2. Exploring new methodologies for efficient supply of biologically-active natural products in combination of total synthesis and biosynthesis.
  3. 3. Sequence specific detection of virus genome by novel type of nucleobases.
  4. 4. Design and synthesis of inhibitors for bacterial efflux pumps.

Figure / Graph

  • Fig.1
    Anti-cancer agents based on natural diterpene glycosides
  • Fig.2
    Identification of virus genome using novel type of nucleobases

VIDEO INTRODUCTION

The Institute of Scientific and Industrial Research, Osaka University

contact home japanese

Department of Organic Fine Chemicals

Staff

  • Photo
    Assis. Prof.
    Y. HIGUCHI
  • Photo
    Specially Appointed Assoc. Prof.
    K. KAIHATSU

Content of research

Based on chemical proteomic approaches, our research interests are focused on the rational design and synthesis of small organic compounds that potentially modulate/inhibit protein-protein interactions. These compounds are also utilized as a tool in our chemical genomic study to elucidate intracellular signaling pathways. Our research also extends into the development of a novel type of nucleobase that can specifically recognize virus genome sequence.

Current Research Programs

  1. 1. Drug discovery based on controlling intracellular signal transductions by low-molecular-weight compounds.
  2. 2. Exploring new methodologies for efficient supply of biologically-active natural products in combination of total synthesis and biosynthesis.
  3. 3. Sequence specific detection of virus genome by novel type of nucleobases.
  4. 4. Design and synthesis of inhibitors for bacterial efflux pumps.

Figure / Graph

  • Fig.1
    Anti-cancer agents based on natural diterpene glycosides
  • Fig.2
    Identification of virus genome using novel type of nucleobases

VIDEO INTRODUCTION