The Institute of Scientific and Industrial Research, Osaka University

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Department of Organic Fine Chemicals

Staff

  • Photo
    Assis. Prof.
    Y. HIGUCHI

Content of research

Based on chemical proteomic approaches, our research interests are focused on the rational design and synthesis of small organic compounds that potentially modulate protein-protein interactions. These compounds are also utilized as a tool in our chemical genomic study to elucidate intracellular signaling pathways.

Current Research Programs

  1. 1. Drug discovery based on controlling intracellular signal transductions by small molecues.
  2. 2. Design and synthesis of inhibitors for bacterial efflux pumps.
  3. 3. Design and synthesis of bioactive lipids as probe molecues for chemical biology and development of the lipid transport acivity monioring system.

Figure / Graph

  • Fig.1
    Anti-cancer agents based on natural diterpene glycosides
  • Fig.2
    Identification of virus genome using novel type of nucleobases

VIDEO INTRODUCTION

The Institute of Scientific and Industrial Research, Osaka University

contact home japanese

Department of Organic Fine Chemicals

Staff

  • Photo
    Assis. Prof.
    Y. HIGUCHI

Content of research

Based on chemical proteomic approaches, our research interests are focused on the rational design and synthesis of small organic compounds that potentially modulate protein-protein interactions. These compounds are also utilized as a tool in our chemical genomic study to elucidate intracellular signaling pathways.

Current Research Programs

  1. 1. Drug discovery based on controlling intracellular signal transductions by small molecues.
  2. 2. Design and synthesis of inhibitors for bacterial efflux pumps.
  3. 3. Design and synthesis of bioactive lipids as probe molecues for chemical biology and development of the lipid transport acivity monioring system.

Figure / Graph

  • Fig.1
    Anti-cancer agents based on natural diterpene glycosides
  • Fig.2
    Identification of virus genome using novel type of nucleobases

VIDEO INTRODUCTION