The Institute of Scientific and Industrial Research, Osaka University

contact
home
japanese
HOME > Research Introduction > Division of Biological and Molecular Sciences > Department of Biomolecular Science and Regulation

Department of Biomolecular Science and Regulation

Staff

  • Photo
    Prof.
    K. NISHINO
  • Photo
    Assoc. Prof.
    T. NISHI
  • Photo
    Assis. Prof.
    S. YAMASAKI
  • Photo
    Assis. Prof.
    M. NISHINO
  • Photo
    Specially Appointed Assoc. Prof.
    S. NAKASHIMA
  • Photo
    Specially Appointed Assis. Prof.
    M. ZWAMA

Content of research

Xenobiotic transporters are widely distributed in living organisms and play important roles in their self-defense mechanisms. Transporters cause a serious chemotherapeutic problem named multidrug resistance in pathogenic bacteria and cancer cells. Recent discoveries also support the notion that some xenobiotic transporters have shown to have important roles in bacterial virulence and signal transduction. We are interested in understanding roles xenobiotic transporters in multidrug resistance and physiological functions. Our knowledge should promote the development of novel inhibitors or strategies that could counteract the contribution of xenobiotic transporters to drug resistance and virulence.

Current Research Programs

  1. 1. Development of therapeutic strategies to control infectious diseases
  2. 2. Regulation and physiological function of xenobiotic transporters
  3. 3. Nanosystems biology of multidrug resistance
  4. 4. Development of new devices to detect multidrug resistant bacteria
  5. 5. 3D imaging of bio-nanostructures by electron tomography
  6. 6. Morphological analysis and identification of multidrug resistant bacteria by deep learning

Figure / Graph

  • Fig.1
    Fig.1. Nanosystems biology of multidrug resistance.
    Science (2005), Proc. Natl. Acad. Sci. USA (2005, 2013), Mol. Microbiol. (2006), J. Biol. Chem. (2008, 2011), Nature (2011), Nature (2013), Nature Commun. (2013)
  • Fig.2
    Fig.2. Mouse SPNS2 expressed on vascular endothelial cells regulates lymphocyte egress into blood.
    Science (2009), J. Biol. Chem. (2011), PLoS One (2012)

VIDEO INTRODUCTION

The Institute of Scientific and Industrial Research, Osaka University

contact home japanese
HOME > Research Introduction > Division of Biological and Molecular Sciences > Department of Biomolecular Science and Regulation

Department of Biomolecular Science and Regulation

Staff

  • Photo
    Prof.
    K. NISHINO
  • Photo
    Assoc. Prof.
    T. NISHI
  • Photo
    Assis. Prof.
    S. YAMASAKI
  • Photo
    Assis. Prof.
    M. NISHINO
  • Photo
    Specially Appointed Assoc. Prof.
    S. NAKASHIMA
  • Photo
    Specially Appointed Assis. Prof.
    M. ZWAMA

Content of research

Xenobiotic transporters are widely distributed in living organisms and play important roles in their self-defense mechanisms. Transporters cause a serious chemotherapeutic problem named multidrug resistance in pathogenic bacteria and cancer cells. Recent discoveries also support the notion that some xenobiotic transporters have shown to have important roles in bacterial virulence and signal transduction. We are interested in understanding roles xenobiotic transporters in multidrug resistance and physiological functions. Our knowledge should promote the development of novel inhibitors or strategies that could counteract the contribution of xenobiotic transporters to drug resistance and virulence.

Current Research Programs

  1. 1. Development of therapeutic strategies to control infectious diseases
  2. 2. Regulation and physiological function of xenobiotic transporters
  3. 3. Nanosystems biology of multidrug resistance
  4. 4. Development of new devices to detect multidrug resistant bacteria
  5. 5. 3D imaging of bio-nanostructures by electron tomography
  6. 6. Morphological analysis and identification of multidrug resistant bacteria by deep learning

Figure / Graph

  • Fig.1
    Fig.1. Nanosystems biology of multidrug resistance.
    Science (2005), Proc. Natl. Acad. Sci. USA (2005, 2013), Mol. Microbiol. (2006), J. Biol. Chem. (2008, 2011), Nature (2011), Nature (2013), Nature Commun. (2013)
  • Fig.2
    Fig.2. Mouse SPNS2 expressed on vascular endothelial cells regulates lymphocyte egress into blood.
    Science (2009), J. Biol. Chem. (2011), PLoS One (2012)

VIDEO INTRODUCTION