Content of research
Xenobiotic transporters are widely distributed in living organisms and play important roles in their self-defense mechanisms. Transporters cause a serious chemotherapeutic problem named multidrug resistance in pathogenic bacteria and cancer cells. Recent discoveries also support the notion that some xenobiotic transporters have shown to have important roles in bacterial virulence and signal transduction. We are interested in understanding roles xenobiotic transporters in multidrug resistance and physiological functions. Our knowledge should promote the development of novel inhibitors or strategies that could counteract the contribution of xenobiotic transporters to drug resistance and virulence.
Current Research Programs
- 1. Development of therapeutic strategies to control infectious diseases
- 2. Regulation and physiological function of xenobiotic transporters
- 3. Nanosystems biology of multidrug resistance
- 4. Development of new devices to detect multidrug resistant bacteria
- 5. 3D imaging of bio-nanostructures by electron tomography
- 6. Morphological analysis and identification of multidrug resistant bacteria by deep learning
Figure / Graph
Fig.1. Nanosystems biology of multidrug resistance.
Science (2005), Proc. Natl. Acad. Sci. USA (2005, 2013), Mol. Microbiol. (2006), J. Biol. Chem. (2008, 2011), Nature (2011), Nature (2013), Nature Commun. (2013)
Fig.2. Mouse SPNS2 expressed on vascular endothelial cells regulates lymphocyte egress into blood.
Science (2009), J. Biol. Chem. (2011), PLoS One (2012)