Kunihiko Nishino and Akihito Yamaguchi
Virulence and Drug Resistance Roles of Multidrug Efflux Pumps in Escherichia coli and Salmonella
Bioscience and Microflora in press (2008)
Hidetada Hirakawa, Asuka Takumi-Kobayashi, Ulrike Theisen, Takahiro Hirata, Kunihiko Nishino and Akihito Yamaguchi
AcrS/EnvR Represses the Expression of the acrAB Multidrug Efflux Genes in Escherichia coli
J. Bacteriol. in press (2008)
abstract
Eiji Nikaido, Akihito Yamaguchi and Kunihiko Nishino
AcrAB Multidrug Efflux Pump Regulation in Salmonella enterica serovar Typhimurium by RamA in Response to Environmental Signals
J. Biol. Chem. in press (2008)
abstract
Kunihiko Nishino and Akihito Yamaguchi
Role of Xenobiotic Transporters in Bacterial Drug Resistance and Virulence
IUBMB Life in press (2008)
abstract
Kunihiko Nishino, Yasuko Senda and Akihito Yamaguchi
The AraC-family regulator GadX enhances multidrug resistance of Escherichia coli by activating expression of the mdtEF multidrug efflux genes
J. Infect. Chemother. 14, 23-29 (2008)
abstract
Kyohei Higashi1, Hiroyuki Ishigure1, Risa Demizu1, Takeshi Uemura1, Kunihiko Nishino, Akihito Yamaguchi, Keiko Kashiwagi2 and Kazuei Igarashi1 (1Graduate School of Pharmaceutical Sciences, Chiba University, 2Faculty of Pharmacy, Chiba Institute of Science)
Identification of a spermidine excretion protein complex (MdtJI) in Escherichia coli
J. Bacteriol. 190, 872-878 (2008)
abstract
Kawasaki-Nishi Shoko, Yamaguchi Akihito, Forgac Michael and Nishi Tsuyoshi
Tissue specific expression of the splice variants of the mouse vacuolar proton-translocating ATPase a4 subunit
Biochem. Biophys. Res. Commun. 364, 1032-1036 (2007)
abstract
Kunihiko Nishino, Eiji Nikaido and Akihito Yamaguchi
Regulation of multidrug efflux systems involved in multidrug and metal resistance of Salmonella enterica serovar Typhimurium
J. Bacteriol. 189, 9066-9075 (2007)
abstract
Satoshi Murakami, Ryosuke Nakashima, Eiki Yamashita๗, Takashi Matsumoto and Akihito Yamaguchi (๗Institute for Protein Research, Osaka University)
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
Nature 443, 173-179 (2006)
abstract
Hidetada Hirakawa, Yoshihiko Inazumi, Yasuko Senda, Asuka Kobayashi, Takahiro Hirata, Kunihiko Nishino and Akihito Yamaguchi
N-acetyl-D-glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite activation in Escherichia coli
J. Bacteriol. 188, 5851?5858 (2006)
abstract
Asuka Kobayashi, Hidetada Hirakawa, Takahiro Hirata, Kunihiko Nishino and Akihito Yamaguchi
Growth phase-dependent expression of drug exporters in Escherichia coli and its contribution to drug tolerance
J. Bacteriol. 188, 5693?5703 (2006)
abstract
Satoshi Yamada1, Naoki Awano1, Kyoko Inubushi1, Eri Maeda1, Shigeru Nakamori1, Kunihiko Nishino2, Akihito Yamaguchi2 and Hiroshi Takagi1 (1Department of Bioscience, Fukui Prefectural University, 2Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University)
Effect of drug transporter genes on cysteine export and overproduction in Escherichia coli
Appl. Environ. Microbiol. 72, 4735-4742 (2006)
abstract
Nobuyoshi Kobayashi, Tsuyoshi Nishi, Takahiro Hirata, Akio Kihara๗, Takamitsu Sano๗, Yasuyuki Igarashi๗ and Akihito Yamaguchi (๗Graduate School of Pharmaceutical Sciences, Hokkaido Univ.)
Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner
J. Lipid Res. 47, 614-621 (2006)
abstract
Satoshi Murakami, Masafumi Kashii๗, Hiroshi Kitano, Hiroaki Adachi๗, Kazufumi Takano๗, Hiroyoshi Matsumura๗, Tsuyoshi Inoue๗, Yusuke Mori๗, Masaaki Doi, Kazuomi Sugamoto๖, Hideki Yoshikawa๖ and Takatomo Sasaki๗, (๗Graduate School of Engineering, Osaka Univ., Cor Technology Center, Nikon Corporation, ๖Department of Orthopaedic Surgery, Faculty of Medicine, Osaka Univ.)
Effect of laser irradiation on enzyme activity
Jpn. J. Appl. Phys. 44, 8216-8218 (2005)
Norihisa Tamura, Satoshi Murakami, Yoshiaki Oyama๗, Masaji Ishiguro๗ and Akihito Yamaguchi, (๗Suntory Inst. for Bioorganic Res. Osaka)
Direct interaction of multidrug efflux transporter AcrB and outer membrane channel TolC detected via site-directed disulfide cross-linking
Biochemistry 44, 11115-11121 (2005)
abstract
Yoshiyuki Kubo๗, Sayaka Sekiya, Megumi Ohigashi, Chiemi Takenaka, Kyoko Tamura, Shigeyuki Nada, Tsuyoshi Nishi, Akitsugu Yamamoto๖ and Akihito Yamaguchi, (๗Kanazawa University Faculty of Pharmaceutical Sciences, Research Institute for Microbial Disease, Osaka Univ. ๖Nagahama Institute of Bio-Science and Technology)
ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms
Mol. Cell. Biol. 25, 4138-4149 (2005)
abstract
Kunihiko Nishino, Takeshi Honda and Akihito Yamaguchi
Genome-Wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system.
J. Bacteriol. 187, 1763-1772 (2005)
abstract
Hidetada Hirakawa, Yoshihiko Inazumi, Takeshi Masaki, Takahiro Hirata and Akihito Yamaguchi
Indole induces the expression of multidrug exporter genes in Escherichia coli.
Mol. Microbiol. 55, 1113-1126 (2005)
abstract
Hiroaki Adachi, Satoshi Murakami, Ai Niino, Hiroyoshi Matsumura, Kazufumi Takano, Tsuyoshi Inoue, Yusuke Mori, Akihito Yamaguchi and Takatomo Sasaki
Membrane Protein Crystallization Using Laser Illradiation.
Jpn. J. Appl. Phys. 43,No.10B, L1376-L1378 (2004)
Takahiro Hirata, Asami Saito, Kunihiko Nishino, Norihisa Tamura and Akihito Yamaguchi
Effects of Efflux Transporter Genes on Susceptibility of Escherichia coli to Tigecycline (GAR-936).
Antimicrob. agents Chemother. 48, 2179-2184 (2004)
abstract
Satoshi Murakami, Norihisa Tamura, Asami Saito, Takahiro Hirata and Akihito Yamaguchi
Extramembrane Central Pore of Multidrug Exporter AcrB in Escherichia coli Plays an Important Role in Drug Transport.
J. Biol. Chem. 279, 3743-3748 (2004)
abstract
Kunihiko Nishino and Akihito Yamaguchi
Role of Histone-Like Protein H-NS in Multidrug Resistance of Escherichia coli.
J. Bacteriol. 186, 1423-1429 (2004)
abstract
Hidetada Hirakawa, Kunihiko Nishino, Junko Yamada, Takahiro Hirata and Akihito Yamaguchi
beta-Lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli.
J. Antimicrob. Chemother. 45, 256-261 (2003)
abstract
Kunihiko Nishino, Junko Yamada, Hidetada Hirakawa, Takahiro Hirata and Akihito Yamaguchi
Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to beta-lactams.
Antimicrob. Agents Chemother. 47, 3030-3033 (2003)
abstract
Norihisa Tamura, Satoko Konishi and Akihito Yamaguchi
Mechanisms of drug/H+ antiport: complete cycteine-scanning mutagenesis and the protein engineering approach.
Curr. Opin. Chem. Biol. 7, 570-579 (2003)
abstract
Satoshi Murakami and Akihito Yamaguchi
Multidrug-exporting secondary transporters
Curr.Opin. Struct. Biol. 13, 443-452 (2003)
abstract
Akihito Yamaguchi, Satoshi Murakami, Ryosuke Nakashima and Eiki Yamashita
Crystal structure of bacterial multidrug efflux transporter AcrB
FASEB J. 17,suppl. A1185 (2003)
Nobuyoshi Kobayashi, Kunihiko Nishino, Takahiro Hirata and Akihito Yamaguchi
Membrane topology of ABC-type macrolide antibiotic exporter MacB in Escherichia coli.
FEBS Lett. 546, 241-246 (2003)
abstract
Kunihiko Nishino, Yoshihiko Inazumi and Akihito Yamaguchi
Global analysis of genes regulated by EvgA of the two-component regulatory system in Escherichia coli.
J. Bacteriol. 185, 2667-2672 (2003)
abstract
Hidetada Hirakawa, Kunihiko Nishino, Takahiro Hirata and Akihito Yamaguchi
Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli.
J. Bacteriol. 185, 1851-1856 (2003)
abstract
Mari Sasaki, Ayako Shoji, Yoshiyuki Kubo, Shigeyuki Nada and Akihito Yamaguchi
Cloning of rat ABCA7 and its preferential expression in platelets.
Biochemical and Biophysical Research Communications. 304, 777-782 (2003)
abstract
Satoshi Murakami and Akihito Yamaguchi
Crystal structure of Acrb
Tanpakushitu. Kakusan. Kouso. (Review in Japanese) 48, 26-32 (2003)
Satoshi Murakami, Ryosuke Nakashima, Eiki Yamashita and Akihito Yamaguchi
Crystal structure of the bacterial multidrug efflux transporter AcrB
Nature 419, 587-593 (2002)
abstract
Satoshi Nagakubo, Kunihiko Nishino, Tkakahiro Hirata and Akihito Yamaguchi
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC
J. Bacteriol. 184, 4161-4167 (2002)
abstract
Kunihiko Nishino and Akihito Yamaguchi
EvgA of the two-component signal transduction system modulates production of the YhiUV multidrug transporter in Escherichia coli.
J. Bacteriol. 184, 2319-2323 (2002)
abstract
Erika Fujihira, Norihisa Tamura and Akihito Yamaguchi
Membrane topology of a multidrug efflux transporter, AcrB in Escherichia coli.
J. Biolchem (Tokyo) 131, 145-151 (2002)
abstract
Norihisa Tamura, Satoko Konishi, Shinobu Iwaki, Tomomi Kimura-Someya, Shigeyuki Nada and Akihito Yamaguchi
Complete cysteine-scanning mutagenesis and site-directed chemical modification of the Tn10-encoded metal-tetracycline/H+ antiporter.
J. Biol. Chem. 276, 20330-20339 (2001)
abstract
Nobuyoshi Kobayashi, Kunihiko Nishino and Akihito Yamaguchi
Novel macrolide-specific ABC-type efflux transporter in Escherichia coli.
J. Bacteriol. 183, 5639-5644 (2001)
abstract
Kunihiko Nishino and Akihito Yamaguchi
Analysis of a complete library of putative drug transporter genes in Escherichia coli.
J. Baceriol. 183, 5803-5812 (2001)
abstract
Shigeyuki Nada, Satoshi Murakami, Shizuka Okamoto, Yoshiyuki Kubo and Akihito Yamaguchi
Monoclonal antibody that binds to the central loop of the Tn10-encoded metal tetracycline/H+ antiporter of Escherichia coli.
J. Biochem. (Tokyo) 129, 87-91 (2001)
abstract
Kunihiko Nishino and Akihito Yamaguchi
Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters.
J. Bacteriol. 183, 1455-1458 (2001)
abstract
Sunghi Ryu, Tetsuro Kawabe, Shigeyuki Nada and Akihito Yamaguchi
Identification of basic residues involved in drug export function of human multidrug resistance-associated protein 2.
J. Biol. Chem. 275, 39617-39624 (2000)
abstract
Tetsuhiro Kawabe, Erika Fujihira and Akihito Yamaguchi
Molecular construction of a multidrug exporter system, AcrAB: Molecular interaction between AcrA and AcrB, and cleavage of the N-terminal signal
sequence of AcrA.
J. Biochem. (Tokyo) 128, 195-200 (2000)
abstract
Shinobu Iwaki, Norihisa Tamura, Tomomi Kimura-Someya, Shigeyuki Nada and Akihito Yamaguchi
Cysteine-scanning mutagenesis of transmembrane segments 4 and 5 of the Tn10-encoded metal-Tetracycline/H+ antiporter reveals a permeability barrier in the middle of a transmembrane water-filled channel.
J. Biol. Chem. 275, 22704-22712 (2000)
abstract
Tomomi Kimura-Someya, Shinobu Iwaki, Satoko Konishi, Norihisa Tamura, Yoshiyuki Kubo and Akihito Yamaguchi
Cysteine-scanning mutagenesis around transmembrane segment 1 and 11 and their flanking loop regions of Tn10-encoded metal-Tetracycline/H+ antiporter.
J. Biol. Chem. 275, 18692-18697 (2000)
abstract
Yoshiyuki Kubo, Satoko Konishi, Tetsuhiro Kawabe, Shigeyuki Nada and Akihito Yamaguchi
Proximity of periplasmic loops in the metal-Tetracycline/H+ antiporter of Escherichia coli observed on site-directed chemical cross-linking.
J. Biol. Chem. 275, 5270-5274 (2000)
abstract
Yuichi Someya, Tomomi Kimura-Someya and Akihito Yamaguchi
Role of the charge interaction between Arg70 and Asp120 in the Tn10-encoded metal-Tetracycline/H+ antiporter of Escherichia coli.
J. Biol. Chem. 275, 210-214 (2000)
abstract
Satoko Konishi, Shinobu Iwaki, Tomomi Kimura-Someya and Akihito Yamaguchi
Cysteine-scanning mutagenesis around transmembrane segment VI of Tn10-encoded metal-Tetracycline/H+ antiporter.
FEBS Lett. 461, 315-318 (1999)
abstract
Tetsuro Kawabe and Akihito Yamaguchi
Transmembrane remote conformational suppression of the Gly332 mutation of the Tn10-encoded metal-Tetracycline/H+ antiporter.
FEBS Lett. 457, 169-173 (1999)
abstract
Takahiro Hirata, Erika Fujihira, Tomomi Kimura-Someya and Akihito Yamaguchi
Membrane topology of the Staphylococcal Tetracycline efflux protein Tet(K) determined by antibacterial resistance gene fusion.
J. Biochem. (Tokyo) 124, 1206-1211 (1998)
abstract
Tomomi Kimura-Someya, Shinobu Iwaki and Akihito Yamaguchi
Site-directed chemical modification of cysteine-scanning mutants as to transmembrane segment II and its flanking regions of the Tn10-encoded metal-tetracycline/H+ antiporter reveals a transmembrane water-filled channel.
J. Biol. Chem. 273, 32806-32811 (1998)
abstract
Takahiro Hirata, Rumi Wakatabe, Joergen Nielsen, Tomoko Satoh, Shin-ichi Nihira and Akihito Yamaguchi
Screening of an inhibitor of the Tetracycline efflux pump in a Tetracycline-resistant clinical-isolate of Staphylococcus aureus 743.
Biol. Pharm. Bull. 21, 678-681 (1998)
abstract
Tomomi Kimura, Mariko Nakatani, Tetsuhiro Kawabe and Akihito Yamaguchi
Roles of conserved arginine residues in the matal-Tetracycline/H+ antiporter of Escherichia coli.
Biochemistry 37, 5475-5480 (1998)
abstract
Tomomi Kimura, Yasuko Shiina, Tetsuo Sawai and Akihito Yamaguchi
Cysteine-scanning mutagenesis around transmembrane segment III of Tn10-encoded metal-Tetracycline/H+ antiporter.
J. Biol. Chem. 273, 5243-5247 (1998)
abstract
Yuichi Someya and Akihito Yamaguchi
Second-site suppressor mutations for the Arg70 substitution mutants of the Tn10-encoded metal-Tetracycline/H+ antiporter of Escherichia coli.
Biochim. Biophys. Acta (Bioenergetics) 1322, 230-236 (1997)
abstract
Erika Fujihira, Tomomi Kimura and Akihito Yamaguchi
Roles of acidic residues in the hydrophilic loop regions of metal-Tetracycline/H+ antiporter Tet(K) of Staphylococcus aureus.
FEBS Lett. 419, 211-214 (1997)
abstract
Takahiro Hirata, Rumi Wakatabe, Joergen Nielsen, Yuichi Someya, Erika Fujihira, Tomomi Kimura and Akihito Yamaguchi
A novel compound, 1,1-dimethyl-5-(1-hydroxypropyl)-4,6,7-trimethylindan,is an effective inhibitor of the tet(K) gene-encoded metal-Tetracycline/H+ antiporter of Staphylococcus aureus.
FEBS Lett. 412, 337-340 (1997)
abstract
Tomomi Kimura, Tetsuo Sawai and Akihito Yamaguchi
Remote conformational effects of the Gly-62 จ Leu mutation of the Tn10-encoded metal-tetracycline/H+ antiporter of Escherichia coli and its second-site suppressor mutation.
Biochemistry 35, 6941-6946 (1997)
abstract
Tomomi Kimura, Masae Ohnuma, Tetsuo Sawai and Akihito Yamaguchi
Membrane topology of the transposon 10-encoded metal-Tetracycline/H+ antiporter studied by site-directed chemical labeling.
J. Biol. Chem. 272, 580-585 (1997)
abstract
Tomomi Kimura, Masayo Suzuki, Tetsuo Sawai and Akihito Yamaguchi
Determination of a transmembrane segment using cysteine-scanning mutants of transposon Tn10-encoded metal-Tetracycline/H+ antiporter.
Biochemistry 35, 15896-15899 (1996)
abstract
Erika Fujihira, Tomomi Kimura, Yasuko Shiina and Akihito Yamaguchi
Transmembrane glutamic acid residues play essential roles in the metal-tetracycline/H+ antiporter of Staphylococcus aureus.
FEBS Lett. 391, 243-246 (1996)
abstract
Yuichi Someya and Akihito Yamaguchi
Mercaptide formed between the residue Cys70 and Hg2+ or Co2+ behaves as a functional positively-charged side chain operative in the Arg70จCys mutant of the metal-Tetracycline/H+ antiporter of Escherichia coli.
Biochemistry 35, 9385-9391 (1996)
abstract
Tomomi Kimura and Akihito Yamaguchi
Asp285 of metal-Tetracycline/H+ antiporter of Escherichia coli is essential for the substrate binding.
FEBS Lett. 388, 50-52 (1996)
abstract
Akihito Yamaguchi, Tomohiro Samejima, Tomomi Kimura and Tetsuo Sawai
His257 is a uniquely important histidine residue for Tetracycline/H+ antiport function but not mandatory for full activity of the transposon Tn10-encoded metal-Tetracycline/H+ antiporter.
Biochemistry 35, 4359-4364 (1996)
abstract
Akihito Yamaguchi, Youko Inagaki and Tetsuo Sawai
Second-site suppressor mutations for the Asp-66จCys mutant of the transposon Tn10-encoded metal-Tetracycline/H+ antiporter of Escherichia coli.
Biochemistry 34, 11800-11806 (1995)
Yuichi Someya, Yoshinori Moriyama, Masamitsu Futai, Tetsuo Sawai and Akihito Yamaguchi
Reconstitution of the metal-Tetracyclline/H+ antiporter of Escherichia coli in proteoliposomes including F0F1-ATPase.
FEBS Lett. 374, 72-76 (1995)
Akihito Yamaguchi, Yasuko Shiina, Erika Fujihira, Tetsuo Sawai, Norihisa Noguch and Masanori Sasatsu
The tetracycline efflux protein encoded by the tet(K) gene from Staphylococcus aureus is a metal-tetracyclline/H+ antiporter.
FEBS Lett. 365, 193-197 (1995)
Tomomi Kimura, Youko Inagaki, Tetsuo Sawai and Akihito Yamaguchi
Substrate-induced acceleration of N-ethylmaleimide reaction with the Cys-65 mutant of the transposon Tn10-encoded metal-Tetracycline/H+ antiporter depends on the interaction of Asp-66 with the substrate.
FEBS Lett. 362, 47-49 (1995)
Yuichi Someya, Akiko Niwa, Tetsuo Sawai and Akihito Yamaguchi
Site-specificity of the second-site suppressor mutation of the Asp-285จAsn
mutant of metal-Tetracyclline/H+ antiporter of Escherichia coli and the effects of amino acid substitutions at the first and second sites.
Biochemistry 34, 7-12 (1995)
Yuichi Someya, Akihito Yamaguchi and Tetsuo Sawai
A novel glycylcycline, 9-(N,N-dimethylglycylamido)-6-demethyl-6-deoxytetracycline,
is neither transported nor recognized by the transposon Tn10-encoded metal-Tetracycline/H+ antiporter.
Antimicrob. Agents Chemother. 39, 247-249 (1994)
Ken Sato, Masa H. Sato, Akihito Yamaguchi and Masasuke Yoshida
Tetracycline/H+ antiporter was degraded rapidly in Escherichia coli cells when truncated at last transmembrane helix and this degradation was protected by overproduced GroEL/ES.
Biochem. Biophys. Res. Commun. 202, 258-264 (1994)
Akihito Yamaguchi, Tomomi Kimura and Tetsuo Sawai
Hot spots for sulfhydryl inactivation of Cys mutants in the widely conserved sequence motifs of the metal-Tetracyclline/H+ antiporter of Escherichia coli.
J. Biochem. (Tokyo) 115, 958-964 (1994)
Akihito Yamaguchi, Rika O'yauchi, Yuichi Someya, Takaaki Akasaka and Tetsuo Sawai
Second-site mutation of Ala-220 to Glu or Asp suppresses the mutation of Asp-285 to Asn in the transposon Tn10-encoded metal-Tetracycline/H+ antiporter of Escherichia coli.
J. Biol. Chem. 268, 26990-26995 (1993)
Akihito Yamaguchi, Yuichi Someya and Tetsuo Sawai
The in vivo assembly and function of the N- and C-terminal halves of the Tn10-encoded TetA protein in Escherichia coli.
FEBS Lett. 324, 131-135 (1993)
Akihito Yamaguchi, Tomomi Kimura and Tetsuo Sawai
Effect of sulfhydryl reagents on the Cys65 mutant of the transposon Tn10-encoded metal-Tetracycline/H+ antiporter of Escherichia coli.
FEBS Lett. 322, 201-204 (1993)
Akihito Yamaguchi, Takaaki Akasaka, Tomomi Kimura, Terumi Sakai, Yuka Adachi and Tetsuo Sawai
Role of the conserved quartets of residues located in the N- and C-terminal halves of the transposon Tn10-encoded metal-tetracycline/H+ antiporter of Escherichia coli.
Biochemistry 32, 5698-5704 (1993)
Akihito Yamaguchi, Tomomi Kimura, Yuichi Someya and Tetsuo Sawai
Metal-Tetracycline/H+ antiporter of Escherichia coli encoded by transposon Tn10: The structural resemblance and functional difference in the role of the duplicated sequence motif between hydrophobic segments 2 and 3 and segments 8 and 9.
J. Biol. Chem. 268, 6496-6504 (1993)
Akihito Yamaguchi, Mariko Nakatani and Tetsuo Sawai
Aspartic acid-66 is the only essential negatively charged residue in the putative hydrophilic loop region of the metal-Tetracycline/H+ antiporter of Escherichia coli encoded by transposon Tn10.
Biochemistry 31, 8344-8348 (1992)
Akihito Yamaguchi, Yuichi Someya and Tetsuo Sawai
Metal-Tetracycline/H+ antiporter of Escherichia coli encoded by transposon Tn10: The role of a conserved sequence motif, GXXXXRXGRR, in a putative cytoplasmic loop between helices 2 and 3.
J. Biol. Chem. 267, 19155-19162 (1992)
Akihito Yamaguchi, Nobukazu Ono, Takaaki Akasaka and Tetsuo Sawai
Serine residues responsible for Tetracycline transport are on a vertical stripe including Asp-84 on one side of transmembrane helix 3 in transposon Tn10-encoded Tetracycline/H+ antiporter of Escherichia coli.
FEBS Lett. 307, 229-232 (1992)
Akihito Yamaguchi, Takaaki Akasaka, Nobukazu Ono, Yuichi Someya, Mariko Nakatani and Tetsuo Sawai
Metal-tetracycline/H+ antiporter of Escherichia coli encoded by transposon Tn10: Roles of the aspartyl residues located in the putative transmembrane helices.
J. Biol. Chem. 267, 7490-7498 (1992)
Akihito Yamaguchi, Yoshiko Iwasaki-Ohba, Nobukazu Ono, Midori Kaneko-Ohdera and Tetsuo Sawai
Stoichiometry of metal-Tetracycline/H+ antiport mediated by transposon Tn10-encoded Tetracycline resistance protein in Escherichia coli.
FEBS Lett. 282, 415-418 (1991)
Akihito Yamaguchi, Kumiko Adachi, Takaaki Akasaka, Nobukazu Ono and Tetsuo Sawai
Metal-Tetracycline/H+ antiporter of Escherichia coli encoded by a transposon Tn10: Histidine257 plays an essential role in H+ translocation.
J. Biol. Chem. 266, 6045-6051 (1991)
Akihito Yamaguchi, Hideki Ohmori, Midori Kaneko-Ohdera, Tamako Nomura and Tetsuo Sawai
ขpH-dependent accumulation of Tetracycline in Escherichia coli.
Antimicrob. Agents Chemother. 35, 53-56 (1991)
Akihito Yamaguchi, Nobukazu Ono, Takaaki Akasaka, Takato Noumi and Tetsuo Sawai
Metal-tetracycline/H+ antiporter of Escherichia coli encoded by a transposon, Tn10: The role of the conserved dipeptide, Ser65-Asp66, in Tetracycline transport.
J. Biol. Chem. 265, 15525-15530 (1990)
Akihito Yamaguchi, Kumiko Adachi and Tetsuo Sawai
Orientation of the carboxyl terminus of the transposon Tn10-encoded tetracycline resistance protein in Escherichia coli.
FEBS Lett. 265, 17-19 (1990)
Akihito Yamaguchi, Takeshi Udagawa and Tetsuo Sawai
Transport of divalent cations with tetracycline as mediated by the transposon Tn10-encoded Tetracycline resistance protein.
J. Biol. Chem. 265, 4809-4813 (1990)
Midori Kaneko, Akihito Yamaguchi and Tetsuo Sawai
Energetics of Tetracycline efflux system encoded by Tn10 in Escherichia coli.
FEBS Lett. 193, 194-198 (1985)