Kobayashi Naoki, Tamura Norihisa, van Veen HW, Yamaguchi Akihito, Murakami Satoshi
β-Lactam Selectivity of Multidrug Transporters AcrB and AcrD Resides in the Proximal Binding Pocket
J. Biol. Chem. Epub ahead of print (2014)
abstract
Ryota Iino, Yoshimi Matsumoto, Kunihiko Nishino, Akihito Yamaguchi and Hiroyuki Noji
Design of a large-scale femtoliter droplet array for single-cell analysis of drug-tolerant and drug resistant bacteria
Front. Microbiol. 4, 1-6 (2013)
abstract
Seiji Yamasaki, Saya Nagasawa, Aiko Fukushima, Mitsuko Hayashi-Nishino and Kunihiko Nishino
Cooperation of the multidrug efflux pump and lipopolysaccharides in the intrinsic antibiotic resistance of Salmonella enterica serovar Typhimurium
J. Antimicrob. Chemother. 68, 1066-1070 (2013)
abstract
Sasaki Mari, Tojo Akihiro, Okochi Yoshifumi, Miyawaki Nana, Kamimura Daisuke, Yamaguchi Akihito, Murakami Masaaki, Okamura Yasushi
Autoimmune disorder phenotypes in Hvcn1-deficient mice
Biochem. J. 450, 295-301 (2013)
abstract
Yamaguchi Masaya, Terao Yutaka, Mori-Yamaguchi Yuka, Domon Hisanori, Sakaue Yuuki, Yagi Tetsuya, Nishino Kunihiko, Yamaguchi Akihito, Nizet Victor, Kawabata Shigetada
Streptococcus pneumoniae Invades Erythrocytes and Utilizes Them to Evade Human Innate Immunity
PLoS One 8, e77282, 1-11 (2013)
abstract
山口明人, 中島良介、櫻井啓介
多剤耐性菌感染症の原因となる多剤排出タンパク質の阻害剤結合構造を決定
実験医学 31, 2272-2276 (2013)
Yamasaki Suguru, Nikaido Eiji, Nakashima Ryosuke, Sakurai Keisuke, Fujiwara Daisuke, Fujii Ikuo, Nishino Kunihiko
The crystal structure of multidrug-resistance regulator RamR with multiple drugs
Nat Commun. 4, 1-7 (2013)
abstract
Ryosuke Nakashima, Keisuke Sakurai, Seiji Yamasaki, Katsuhiko Hayashi, Chikahiro Nagata, Kazuki Hoshino, Yoshikuni Onodera, Kunihiko Nishino and Akihito Yamaguchi
Structural basis for the inhibition of bacterial multidrug exporters
Nature, 500, 120-126 (2013)
abstract
Ryota Iino, Kohei Hayama, Hiromi Amezawa, Shouichi Sakakihara, Soo Hyeon Kim, Yoshimi Matsumono, Kunihiko Nishino, Akihito Yamaguchi,Hiroyuki Noji
A single-cell drug efflux assay in bacteria by using a directly accessible femtoliter droplet array
Lab Chip. 12, 3923-3929 (2012)
Yu Hisano, Tsuyoshi Nishi, Atsuo Kawahara
The functional roles of S1P in immunity
J Biochem. 152, 305-311 (2012)
abstract
Yu Hisano, Naoki Kobayashi, Akihito Yamaguchi, Tsuyoshi Nishi
Mouse SPNS2 functions as a sphingoshine-1-phosphate transporter in vascular endothelial cells
PLoS One 7, e38941, 1-11 (2012)
abstract
Yoshimi Matsumoto, Kunihiro Kaihatsu, Kunihiko Nishino, Miho Ogawa, Nobuo Kato, AkihitoYamaguchi
Antibacterial and antifungal activities of new acylated derivatives of epigallocatechin gallate
Front Microbiol. 3, article53 1-10 (2012)
abstract
Ryota Iino, Kunihiko Nishino, Hiroyuki Noji, Akihito Yamaguchi, Yoshimi Matsumoto
A microfluidic device for simple and rapid evaluation of multidrug efflux pump inhibitors
Front Microbiol. 3, article40 1-9 (2012)
Eiji Nikaido, Etienne Giraud, Sylvie Baucheron, Suguru Yamasaki, Agnes Wiedemann, Kousuke Okamoto, Tatsuya Takagi, Akihito Yamaguchi, Axel Cloeckaert, Kunihiko Nishino
Effects of indole on drug resistance and virulence of Salmonella enterica serovar Typhimurium revealed by genome-wide analyses
Gut Pathog. 4, 1-13 (2012)
abstract
Michiko Takahashi, Akie Kawamura, Nobuo Kato, Tsuyoshi Nishi, Itaru Hamachi, Junko Ohkanda
Phosphopeptide-dependent fluorescence labeling of 14-3-3ζ proteins by fusicoccin-based fluorescent probes
Angew. Chem. Int. Ed. 51, 509-512 (2012)
山口明人、中島良介
多剤耐性細菌の異物排出タンパク質のしくみを解明
化学 2, 74-75 (2012)
Yiliang Zhang, Minfeng Xiao, Tsukasa Horiyama, Yinfeng Zhang, Xuechen Li, Kunihiko Nishino and Aixin Yan
The Multidrug Efflux Pump MdtEF Protects against Nitrosative Damage during the Anaerobic Respiration in Escherichia coli
J. Biol. Chem. 286, 26576-26584 (2011)
Ryosuke Nakashima, Keisuke Sakurai, Seiji Yamasaki, Kunihiko Nishino, Akihito Yamaguchi
Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
Nature 480, 565-569 (2011)
abstract
Seiji Yamasaki, Saya Nagasawa, Mitsuko Hayashi-Nishino, Akihito Yamaguchi, and Kunihiko Nishino
AcrA dependency of the AcrD efflux pump in Salmonella enterica serovar Typhimurium
The Journal of Antibiotics 64, 433-437 (2011)
abstract
Yoshimi Matsumoto, Kohei Hayama, Syoichi Sakakihara, Kunihiko Nishino, Hiroaki Noji, Ryota Iino and Akihito Yamaguchi
Evaluation of multidrug efflux pump inhibitors by a new method using microfluidic channels
PLoS One 6, e18547 (2011)
abstract
西野邦彦
薬剤排出ポンプによる細菌多剤耐性化･病原性発現制御
化学療法の領域 27, (2011)
Eiji Nikaido, Ikue Shirosaka, Akihito Yamaguchi and Kunihiko Nishino
Regulation of AcrAB multidrug efflux pump in Salmonella enterica serovar Typhimurium in response to indole and paraquat
Microbiology 157, 648-655 (2011)
abstract
Kunihiko Nishino, Seiji Yamasaki, Mitsuko Hayashi-Nishino and Akihito Yamaguchi
Effect of overexpression of small non-coding DsrA RNA on multidrug efflux in Escherichia coli
The Journal of Antimicrobial Chemotherapy 66, 291-6 (2011)
abstract
Tsukasa Horiyama, Eiji Nikaido, Akihito Yamaguchi, and Kunihiko Nishino
Roles of Salmonella multidrug efflux pumps in tigecycline resistance
The Journal of Antimicrobial Chemotherapy 66, 105-10 (2011)
abstract
西野邦彦、山﨑聖司、西野-林美都子、山口明人
総説: Small RNA による多剤耐性制御
日本化学療法学会雑誌 59, 1-7 (2011)
西野邦彦
エピジェネティクスと細菌の多剤耐性制御
表面 48, 365-374 (2010)
Yu Hisano, Naoki Kobayashi, Atsuo Kawahara, Akihito Yamaguchi, Tsuyoshi Nishi
The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720
The Journal of Biological Chemistry 286, 1758-66 (2011)
abstract
Hidetada Hirakawa, Mitsuko Hayashi-Nishino, Akihito Yamaguchi, Kunihiko Nishino
Indole enhances acid resistance in Escherichia coli
Microbial Pathogenesis 49, 90-4 (2010)
abstract
Tsukasa Horiyama, Akihito Yamaguchi, Kunihiko Nishino
TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium
Journal of Antimicrobial Chemotherapy 65, 1372-6 (2010)
abstract
Dan Ye, Illiana Meurs, Megumi Ohigashi, Laura Calpe-Berdiel, Kim L.L. Habets, Ying Zhao, Yoshiyuki Kubo, Akihito Yamaguchi, Theo J.C. Van Berkel, Tsuyoshi Nishi, Miranda Van Eck
Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice
Biochemical and Biophysical Research Communications 395, 387-94 (2010)
abstract
Mitsuko Hayashi-Nishino, Naonobu Fujita, Takeshi Noda, Akihito Yamaguchi, Tamotsu Yoshimori, Akitsugu Yamamoto
Electron tomography reveals the endoplasmic reticulum as a membrane source for autophagosome formation
Autophagy 6, 301-303(2010)
abstract
山口明人
化学療法学 -医療のあるべき姿を見据えて- [抗生物質最前線] （山口明人編著）
京都廣川書店 , (2010)
Hayashi-Nishino M, Fujita N, Noda T, Yamaguchi A, Yoshimori T and Yamamoto A
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation
Nature Cell Biology 11, 1433-1437 (2009)
abstract
Kunihiko Nishino, Mitsuko Hayashi-Nishino, Akihito Yamaguchi
H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF
Antimicrobial Agents and Chemotherapy 53, 3541-3543 (2009)
abstract
Naoki Kobayashi, Nobuyoshi Kobayashi, Akihito Yamaguchi and Tsuyoshi Nishi
Characterization of the ATP-dependent sphingosine-1-phosphate transporter in rat erythrocytes
The Journal of Biological Chemistry 284, 21192-21200 (2009)
abstract
川原敦雄、西毅、山口明人、望月直樹
スフィンゴシン-1-リン酸の輸送体Spns2は心臓前駆細胞の移動を制御する
細胞工学 28, 390-391 (2009)
Kunihiko Nishino, Yasuko Senda, Mitsuko Hayashi-Nishino and Akihito Yamaguchi
Role of the AraC/XylS family regulator YdeO in multidrug resistance of Escherichia coli
The Journal of Antibiotics 62, 251-257 (2009)
abstract
Kunihiko Nishino, Eiji Nikaido and Akihito Yamaguchi
Regulation and physiological function of multidrug efflux pumps in Escherichia coli and Salmonella
Biochimica et Biophysica Acta - Proteins & Proteomics 1794, 834-43 (2009)
abstract
二階堂英司、城阪郁江、山口明人、西野邦彦
サルモネラ多剤耐性化に関与する多剤排出トランスポーターAcrAB誘導機構の解析
臨床薬理の進歩 30, 77-84 (2009)
Hidetada Hirakawa, Toshio Kodama, Asuka Takumi-Kobayashi, Takeshi Honda and Akihito Yamaguchi
Secreted indole serves as a signal for expression of type III secretion system translocators in enterohaemorrhagic Escherichia coli O157:H7
Microbiology 155, 541-550 (2009)
abstract
Atsuo Kawahara, Tsuyoshi Nishi, Yu Hisano, Hajime Fukui, Akihito Yamaguchi and Naoki Mochizuki
The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors
Science 323, 524-527 (2009)
abstract
山口明人、中島良介
トランスポーターによる多剤認識の構造的基礎
遺伝子医学MOOK12 株式会社メディカルドゥ 12, 61-66 (2009)
Naonobu Fujita1.2, Mitsuko Hayashi-Nishino3, Hiromi Fukumoto1, Hiroko Omori1, Akitsugu Yamamoto3, Takeshi Noda1 and Tamotsu Yoshimori1.4 (1.Osaka University, 2.The Graduate University for Advanced Studies, 3.Nagahama Institute of Bio-Science and Technology, 4.CREST)
An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure
Molecular Biology of the Cell 19, 6451-6459 (2008)
abstract
西野-林美都子1、Pietro De Camilli2 （1.大阪大学産業科学研究所, 2.Department of Cell Biology/HHMI, Yale University School of Medicine）
シナプス小胞再生経路におけるダイナミン１の選択的役割
蛋白質核酸酵素 53, 2225-2230 (2008)
西野邦彦、山口明人
総説 グラム陰性菌における薬剤排出システムの役割
日本化学療法学会雑誌 56, 443-452 (2008)
Kunihiko Nishino
Roles of Multidrug Efflux Pumps in Escherichia coli and Salmonella
Journal of Intestinal Microbiology 22, 64 (2008)
Kunihiko Nishino and Akihito Yamaguchi
Virulence and Drug Resistance Roles of Multidrug Efflux Pumps in Escherichia coli and Salmonella
Bioscience and Microflora 27, 75-85 (2008)
Hidetada Hirakawa, Asuka Takumi-Kobayashi, Ulrike Theisen, Takahiro Hirata, Kunihiko Nishino and Akihito Yamaguchi
AcrS/EnvR Represses the Expression of the acrAB Multidrug Efflux Genes in Escherichia coli
J. Bacteriol. 190, 6276-6279 (2008)
abstract
Eiji Nikaido, Akihito Yamaguchi and Kunihiko Nishino
AcrAB Multidrug Efflux Pump Regulation in Salmonella enterica serovar Typhimurium by RamA in Response to Environmental Signals
J. Biol. Chem. 283,24245-24253 (2008)
abstract
山口明人他、分担執筆
15. トランスポーターの構造と多剤認識・排出機構トランスポーター科学最前線 -フロンティアサイエンスへの招き-
京都 廣川書店 (辻 彰 総編集) 305-320 (2008)
西野邦彦
総論 ２．難治化の菌側要因 1）病原性発現と薬剤耐性化における排出ポンプの役割
化学療法の領域 24. 354-362 (2008)
Kunihiko Nishino
Roles of drug efflux pumps in bacterial multidrug resistance and virulence
- Analysis to identify novel drug targets and counteract multidrug resistance and virulence -
The Japanese Journal of Antibiotics 61, 105-113 (2008)
Kunihiko Nishino and Akihito Yamaguchi
Role of Xenobiotic Transporters in Bacterial Drug Resistance and Virulence
IUBMB Life in press (2008)
abstract
Kunihiko Nishino, Yasuko Senda and Akihito Yamaguchi
CRP regulator modulates multidrug resistance of Escherichia coli by repressing expression of the mdtEF multidrug efflux genes
J. Antibiot. 61, 120-127 (2008)
abstract
Kunihiko Nishino, Yasuko Senda and Akihito Yamaguchi
The AraC-family regulator GadX enhances multidrug resistance of Escherichia coli by activating expression of the mdtEF multidrug efflux genes
J. Infect. Chemother. 14, 23-29 (2008)
abstract
Kyohei Higashi1, Hiroyuki Ishigure1, Risa Demizu1, Takeshi Uemura1, Kunihiko Nishino, Akihito Yamaguchi, Keiko Kashiwagi2 and Kazuei Igarashi1 (1Graduate School of Pharmaceutical Sciences, Chiba University, 2Faculty of Pharmacy, Chiba Institute of Science)
Identification of a spermidine excretion protein complex (MdtJI) in Escherichia coli
J. Bacteriol. 190, 872-878 (2008)
abstract
Kawasaki-Nishi Shoko, Yamaguchi Akihito, Forgac Michael and Nishi Tsuyoshi
Tissue specific expression of the splice variants of the mouse vacuolar proton-translocating ATPase a4 subunit
Biochem. Biophys. Res. Commun. 364, 1032-1036 (2007)
abstract
村上聡
多剤排出トランスポーターの結晶構造解析により明らかになった機能的回転メカニズム
生物物理 47, 309-316 (2007)
村上聡
多剤排出トランスポーターの構造と機能
表面科学 28, 184-191 (2007)
Kunihiko Nishino, Eiji Nikaido and Akihito Yamaguchi
Regulation of multidrug efflux systems involved in multidrug and metal resistance of Salmonella enterica serovar Typhimurium
J. Bacteriol. 189, 9066-9075 (2007)
abstract
山口明人
異物排出タンパクのメカニズム
感染・炎症・免疫 第37巻, 106-115 (2007)
村上聡
大腸菌の異物排出トランスポーターAcrBの構造と異物認識機構
生化学 79, 542-549 (2007)
村上聡
多剤排出トランスポーターの構造と機能 結晶構造から明らかになった機能的回転メカニズム
蛋白質核酸酵素 52, 406-414 (2007)
西野邦彦
薬剤耐性と病原性発現における異物排出トランスポーターの役割 -新時代の基礎・臨床研究-
日本臨牀 新感染症学 65巻・上巻（増刊号2）, 407-414 (2007)
村上聡
タンパク質結晶構造解析入門-ブラックボックスの中身-（3）モデリングの中身をのぞいてみよう 位相改良による電子密度図のリファイン
日本結晶学会誌 46, 381-386 (2006)
村上聡
薬剤耐性化のなぞにせまる─多剤排出トランスポーターの薬剤認識・排出機構
Bionics 12月号, 38-43 (2006)
村上聡
細菌に薬がきかなくなる最大の“カラクリ”
Newton 11月号, (2006)
Satoshi Murakami, Ryosuke Nakashima, Eiki Yamashita¶, Takashi Matsumoto and Akihito Yamaguchi (¶Institute for Protein Research, Osaka University)
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
Nature 443, 173-179 (2006)
abstract
Hidetada Hirakawa, Yoshihiko Inazumi, Yasuko Senda, Asuka Kobayashi, Takahiro Hirata, Kunihiko Nishino and Akihito Yamaguchi
N-acetyl-D-glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite activation in Escherichia coli
J. Bacteriol. 188, 5851?5858 (2006)
abstract
Asuka Kobayashi, Hidetada Hirakawa, Takahiro Hirata, Kunihiko Nishino and Akihito Yamaguchi
Growth phase-dependent expression of drug exporters in Escherichia coli and its contribution to drug tolerance
J. Bacteriol. 188, 5693?5703 (2006)
abstract
Satoshi Yamada1, Naoki Awano1, Kyoko Inubushi1, Eri Maeda1, Shigeru Nakamori1, Kunihiko Nishino2, Akihito Yamaguchi2 and Hiroshi Takagi1 (1Department of Bioscience, Fukui Prefectural University, 2Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University)
Effect of drug transporter genes on cysteine export and overproduction in Escherichia coli
Appl. Environ. Microbiol. 72, 4735-4742 (2006)
abstract
Nobuyoshi Kobayashi, Tsuyoshi Nishi, Takahiro Hirata, Akio Kihara¶, Takamitsu Sano¶, Yasuyuki Igarashi¶ and Akihito Yamaguchi (¶Graduate School of Pharmaceutical Sciences, Hokkaido Univ.)
Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner
J. Lipid Res. 47, 614-621 (2006)
abstract
村上聡（分担執筆）
多剤耐性化を引き起こす薬剤排出タンパク質
タンパク質のかたちから生命の謎を解く 生物マシーナリー構造生物学の最前線
（株式会社クバプロ・編集者：田之倉優） 総ページ数：232頁、178-190 (2005)
山口明人（分担執筆）
タンパク質科学 構造・物性・機能
（化学同人・編集者：後藤祐児、桑島邦博、谷澤克行） 総ページ数579頁、 505-517 (2005)
西毅
サブユニットアイソフォームによるV-ATPaseの機能の制御
生化学 77、 354-358 (2005)
Satoshi Murakami, Masafumi Kashii¶, Hiroshi Kitano§, Hiroaki Adachi¶, Kazufumi Takano¶, Hiroyoshi Matsumura¶, Tsuyoshi Inoue¶, Yusuke Mori¶, Masaaki Doi§, Kazuomi Sugamoto‡, Hideki Yoshikawa‡ and Takatomo Sasaki¶, (¶Graduate School of Engineering, Osaka Univ., §Cor Technology Center, Nikon Corporation, ‡Department of Orthopaedic Surgery, Faculty of Medicine, Osaka Univ.)
Effect of laser irradiation on enzyme activity
Jpn. J. Appl. Phys. 44, 8216-8218 (2005)
Norihisa Tamura, Satoshi Murakami, Yoshiaki Oyama¶, Masaji Ishiguro¶ and Akihito Yamaguchi, (¶Suntory Inst. for Bioorganic Res. Osaka)
Direct interaction of multidrug efflux transporter AcrB and outer membrane channel TolC detected via site-directed disulfide cross-linking
Biochemistry 44, 11115-11121 (2005)
abstract
Yoshiyuki Kubo¶, Sayaka Sekiya, Megumi Ohigashi, Chiemi Takenaka, Kyoko Tamura, Shigeyuki Nada§, Tsuyoshi Nishi, Akitsugu Yamamoto‡ and Akihito Yamaguchi, (¶Kanazawa University Faculty of Pharmaceutical Sciences, §Research Institute for Microbial Disease, Osaka Univ. ‡Nagahama Institute of Bio-Science and Technology)
ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms
Mol. Cell. Biol. 25, 4138-4149 (2005)
abstract
Kunihiko Nishino, Takeshi Honda and Akihito Yamaguchi
Genome-Wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system.
J. Bacteriol. 187, 1763-1772 (2005)
abstract
Kunihiko Nishino, Takeshi Honda and Akihito Yamaguchi
Genome-Wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system.
J. Bacteriol. 187, 1763-1772 (2005)
abstract
Hidetada Hirakawa, Yoshihiko Inazumi, Takeshi Masaki, Takahiro Hirata and Akihito Yamaguchi
Indole induces the expression of multidrug exporter genes in Escherichia coli.
Mol. Microbiol. 55, 1113-1126 (2005)
abstract
横山謙、西毅
精巧な仕組みを持つプロトンポンプ、V型ATPase
蛋白質・核酸・酵素 49、 2035-2043 (2004)
abstract
Hiroaki Adachi, Satoshi Murakami, Ai Niino, Hiroyoshi Matsumura, Kazufumi Takano, Tsuyoshi Inoue, Yusuke Mori, Akihito Yamaguchi and Takatomo Sasaki
Membrane Protein Crystallization Using Laser Illradiation.
Jpn. J. Appl. Phys. 43,No.10B, L1376-L1378 (2004)
Takahiro Hirata, Asami Saito, Kunihiko Nishino, Norihisa Tamura and Akihito Yamaguchi
Effects of Efflux Transporter Genes on Susceptibility of Escherichia coli to Tigecycline (GAR-936).
Antimicrob. agents Chemother. 48, 2179-2184 (2004)
abstract
村上聡、山口明人
薬剤排出タンパク質の構造と機能 ～薬剤耐性化の克服を目指して
バイオサイエンスとインダストリー 62, 11-16 (2004)
Satoshi Murakami, Norihisa Tamura, Asami Saito, Takahiro Hirata and Akihito Yamaguchi
Extramembrane Central Pore of Multidrug Exporter AcrB in Escherichia coli Plays an Important Role in Drug Transport.
J. Biol. Chem. 279, 3743-3748 (2004)
abstract
Kunihiko Nishino and Akihito Yamaguchi
Role of Histone-Like Protein H-NS in Multidrug Resistance of Escherichia coli.
J. Bacteriol. 186, 1423-1429 (2004)
abstract
Hidetada Hirakawa, Kunihiko Nishino, Junko Yamada, Takahiro Hirata and Akihito Yamaguchi
β-Lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli.
J. Antimicrob. Chemother. 45, 256-261 (2003)
abstract
Kunihiko Nishino, Junko Yamada, Hidetada Hirakawa, Takahiro Hirata and Akihito Yamaguchi
Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to β-lactams.
Antimicrob. Agents Chemother. 47, 3030-3033 (2003)
abstract
村上聡、中島良介、山下栄樹、山口明人
大腸菌多剤排出トランスポーターAcrBの結晶構造解析
日本結晶学会誌 45, 256-261 (2003)
abstract
Norihisa Tamura, Satoko Konishi and Akihito Yamaguchi
Mechanisms of drug/H+ antiport: complete cycteine-scanning mutagenesis and the protein engineering approach.
Curr. Opin. Chem. Biol. 7, 570-579 (2003)
abstract
Satoshi Murakami and Akihito Yamaguchi
Multidrug-exporting secondary transporters
Curr.Opin. Struct. Biol. 13, 443-452 (2003)
abstract
村上聡、 中島良介、山下栄樹、山口明人
大腸菌多剤排出トランスポーターのX線結晶構造解析
放射光 16, 204-212 (2003)
Akihito Yamaguchi, Satoshi Murakami, Ryosuke Nakashima and Eiki Yamashita
Crystal structure of bacterial multidrug efflux transporter AcrB
FASEB J. 17,suppl. A1185 (2003)
Nobuyoshi Kobayashi, Kunihiko Nishino, Takahiro Hirata and Akihito Yamaguchi
Membrane topology of ABC-type macrolide antibiotic exporter MacB in Escherichia coli.
FEBS Lett. 546, 241-246 (2003)
abstract
村上聡、 中島良介、山下栄樹、山口明人
多剤排出トランスポーターAcrBの結晶構造解析
生物工学. 81, 155-160 (2003)
Kunihiko Nishino, Yoshihiko Inazumi and Akihito Yamaguchi
Global analysis of genes regulated by EvgA of the two-component regulatory system in Escherichia coli.
J. Bacteriol. 185, 2667-2672 (2003)
abstract
Hidetada Hirakawa, Kunihiko Nishino, Takahiro Hirata and Akihito Yamaguchi
Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli.
J. Bacteriol. 185, 1851-1856 (2003)
abstract
Mari Sasaki, Ayako Shoji, Yoshiyuki Kubo, Shigeyuki Nada and Akihito Yamaguchi
Cloning of rat ABCA7 and its preferential expression in platelets.
Biochemical and Biophysical Research Communications. 304, 777-782 (2003)
abstract
村上聡、山口明人
異物排出トランスポーターの結晶構造、ついに決まる。
蛋白質・核酸・酵素 48, 26-32 (2003)
abstract
村上聡、山口明人
多剤排出トランスポーターAcrBの結晶構造解析。
細胞工学 21, 1520-1521 (2002)
Satoshi Murakami, Ryosuke Nakashima, Eiki Yamashita and Akihito Yamaguchi
Crystal structure of bacterial multidrug efflux transporter AcrB
Nature 419, 587-593 (2002)
abstract
Satoshi Nagakubo, Kunihiko Nishino, Tkakahiro Hirata and Akihito Yamaguchi
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC
J. Bacteriol. 184, 4161-4167 (2002)
abstract
Kunihiko Nishino and Akihito Yamaguchi
EvgA of the two-component signal transduction system modulates production of the YhiUV multidrug transporter in Escherichia coli.
J. Bacteriol. 184, 2319-2323 (2002)
abstract
西野邦彦、山口明人
細菌ゲノムに潜む薬剤耐性因子
日本細菌学雑誌 57, 453-464 (2002)
Erika Fujihira, Norihisa Tamura and Akihito Yamaguchi
Membrane topology of a multidrug efflux transporter, AcrB, in Escherichia coli.
J. Biolchem (Tokyo) 131, 145-151 (2002)
abstract
Norihisa Tamura, Satoko Konishi, Shinobu Iwaki, Tomomi Kimura-Someya, Shigeyuki Nada and Akihito Yamaguchi
Complete cysteine-scanning mutagenesis and site-directed chemical modification of the Tn10-encoded metal-tetracycline/H+ antiporter.
J. Biol. Chem. 276, 20330-20339 (2001)
abstract
Nobuyoshi Kobayashi, Kunihiko Nishino and Akihito Yamaguchi
Novel macrolide-specific ABC-type efflux transporter in Escherichia coli.
J. Bacteriol. 183, 5639-5644 (2001)
abstract
Kunihiko Nishino and Akihito Yamaguchi
Analysis of a complete library of putative drug transporter genes in Escherichia coli.
J. Baceriol. 183, 5803-5812 (2001)
abstract
Shigeyuki Nada, Satoshi Murakami, Shizuka Okamoto, Yoshiyuki Kubo and Akihito Yamaguchi
Monoclonal antibody that binds to the central loop of the Tn10-encoded metal tetracycline/H+ antiporter of Escherichia coli.
J. Biochem. (Tokyo) 129, 87-91 (2001)
abstract
Kunihiko Nishino and Akihito Yamaguchi
Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters.
J. Bacteriol. 183, 1455-1458 (2001)
abstract
Sunghi Ryu, Tetsuro Kawabe, Shigeyuki Nada and Akihito Yamaguchi
Identification of basic residues involved in drug export function of human multidrug resistance-associated protein 2.
J. Biol. Chem. 275, 39617-39624 (2000)
abstract
Tetsuhiro Kawabe, Erika Fujihira and Akihito Yamaguchi
Molecular construction of a multidrug exporter system, AcrAB: Molecular interaction between AcrA and AcrB, and cleavage of the N-terminal signal
sequence of AcrA.
J. Biochem. (Tokyo) 128, 195-200 (2000)
abstract
Shinobu Iwaki, Norihisa Tamura, Tomomi Kimura-Someya, Shigeyuki Nada and Akihito Yamaguchi
Cysteine-scanning mutagenesis of transmembrane segments 4 and 5 of the Tn10-encoded metal-Tetracycline/H+ antiporter reveals a permeability barrier in the middle of a transmembrane water-filled channel.
J. Biol. Chem. 275, 22704-22712 (2000)
abstract
山口明人、西野邦彦
薬剤排出タンパク質とゲノム創薬への応用。
バイオサイエンスとインダストリー 58, 11-16 (2000)
Tomomi Kimura-Someya, Shinobu Iwaki, Satoko Konishi, Norihisa Tamura, Yoshiyuki Kubo and Akihito Yamaguchi
Cysteine-scanning mutagenesis around transmembrane segment 1 and 11 and their flanking loop regions of Tn10-encoded metal-Tetracycline/H+ antiporter.
J. Biol. Chem. 275, 18692-18697 (2000)
abstract
Yoshiyuki Kubo, Satoko Konishi, Tetsuhiro Kawabe, Shigeyuki Nada and Akihito Yamaguchi
Proximity of periplasmic loops in the metal-Tetracycline/H+ antiporter of Escherichia coli observed on site-directed chemical cross-linking.
J. Biol. Chem. 275, 5270-5274 (2000)
abstract
Yuichi Someya, Tomomi Kimura-Someya and Akihito Yamaguchi
Role of the charge interaction between Arg70 and Asp120 in the Tn10-encoded metal-Tetracycline/H+ antiporter of Escherichia coli.
J. Biol. Chem. 275, 210-214 (2000)
abstract
Satoko Konishi, Shinobu Iwaki, Tomomi Kimura-Someya and Akihito Yamaguchi
Cysteine-scanning mutagenesis around transmembrane segment VI of Tn10-encoded metal-Tetracycline/H+ antiporter.
FEBS Lett. 461, 315-318 (1999)
abstract
Tetsuro Kawabe and Akihito Yamaguchi
Transmembrane remote conformational suppression of the Gly332 mutation of the Tn10-encoded metal-Tetracycline/H+ antiporter.
FEBS Lett. 457, 169-173 (1999)
abstract
Takahiro Hirata, Erika Fujihira, Tomomi Kimura-Someya and Akihito Yamaguchi
Membrane topology of the Staphylococcal Tetracycline efflux protein Tet(K) determined by antibacterial resistance gene fusion.
J. Biochem. (Tokyo) 124, 1206-1211 (1998)
abstract
Tomomi Kimura-Someya, Shinobu Iwaki and Akihito Yamaguchi
Site-directed chemical modification of cysteine-scanning mutants as to transmembrane segment II and its flanking regions of the Tn10-encoded metal-tetracycline/H+ antiporter reveals a transmembrane water-filled channel.
J. Biol. Chem. 273, 32806-32811 (1998)
abstract
Takahiro Hirata, Rumi Wakatabe, Joergen Nielsen, Tomoko Satoh, Shin-ichi Nihira and Akihito Yamaguchi
Screening of an inhibitor of the Tetracycline efflux pump in a Tetracycline-resistant clinical-isolate of Staphylococcus aureus 743.
Biol. Pharm. Bull. 21, 678-681 (1998)
abstract
Tomomi Kimura, Mariko Nakatani, Tetsuhiro Kawabe and Akihito Yamaguchi
Roles of conserved arginine residues in the matal-Tetracycline/H+ antiporter of Escherichia coli.
Biochemistry 37, 5475-5480 (1998)
abstract
Tomomi Kimura, Yasuko Shiina, Tetsuo Sawai and Akihito Yamaguchi
Cysteine-scanning mutagenesis around transmembrane segment III of Tn10-encoded metal-Tetracycline/H+ antiporter.
J. Biol. Chem. 273, 5243-5247 (1998)
abstract
Yuichi Someya and Akihito Yamaguchi
Second-site suppressor mutations for the Arg70 substitution mutants of the Tn10-encoded metal-Tetracycline/H+ antiporter of Escherichia coli.
Biochim. Biophys. Acta (Bioenergetics) 1322, 230-236 (1997)
abstract
Erika Fujihira, Tomomi Kimura and Akihito Yamaguchi
Roles of acidic residues in the hydrophilic loop regions of metal-Tetracycline/H+ antiporter Tet(K) of Staphylococcus aureus.
FEBS Lett. 419, 211-214 (1997)
abstract
Takahiro Hirata, Rumi Wakatabe, Joergen Nielsen, Yuichi Someya, Erika Fujihira, Tomomi Kimura and Akihito Yamaguchi
A novel compound, 1,1-dimethyl-5-(1-hydroxypropyl)-4,6,7-trimethylindan,is an effective inhibitor of the tet(K) gene-encoded metal-Tetracycline/H+ antiporter of Staphylococcus aureus.
FEBS Lett. 412, 337-340 (1997)
abstract
Tomomi Kimura, Tetsuo Sawai and Akihito Yamaguchi
Remote conformational effects of the Gly-62 → Leu mutation of the Tn10-encoded metal-tetracycline/H+ antiporter of Escherichia coli and its second-site suppressor mutation.
Biochemistry 35, 6941-6946 (1997)
abstract
山口明人
細菌の多剤排出蛋白 その構造と機能
ファルマシア 33, 609-613 (1997)
山口明人
細菌のアンチポーター型薬剤排出蛋白質
蛋白質核酸酵素 42, 1253-1262 (1997)
山口明人
テトラサイクリン系薬剤の耐性機構
日本臨床 55, 1245-1251 (1997)
abstract
Tomomi Kimura, Masae Ohnuma, Tetsuo Sawai and Akihito Yamaguchi
Membrane topology of the transposon 10-encoded metal-Tetracycline/H+ antiporter studied by site-directed chemical labeling.
J. Biol. Chem. 272, 580-585 (1997)
abstract
Tomomi Kimura, Masayo Suzuki, Tetsuo Sawai and Akihito Yamaguchi
Determination of a transmembrane segment using cysteine-scanning mutants of transposon Tn10-encoded metal-Tetracycline/H+ antiporter.
Biochemistry 35, 15896-15899 (1996)
abstract
Erika Fujihira, Tomomi Kimura, Yasuko Shiina and Akihito Yamaguchi
Transmembrane glutamic acid residues play essential roles in the metal-tetracycline/H+ antiporter of Staphylococcus aureus.
FEBS Lett. 391, 243-246 (1996)
abstract
Yuichi Someya and Akihito Yamaguchi
Mercaptide formed between the residue Cys70 and Hg2+ or Co2+ behaves as a functional positively-charged side chain operative in the Arg70→Cys mutant of the metal-Tetracycline/H+ antiporter of Escherichia coli.
Biochemistry 35, 9385-9391 (1996)
abstract
Tomomi Kimura and Akihito Yamaguchi
Asp285 of metal-Tetracycline/H+ antiporter of Escherichia coli is essential for the substrate binding.
FEBS Lett. 388, 50-52 (1996)
abstract
山口明人
細菌薬剤排出蛋白の分子機構
バイオサイエンスとインダストリー 54, 415-419 (1996)
Akihito Yamaguchi, Tomohiro Samejima, Tomomi Kimura and Tetsuo Sawai
His257 is a uniquely important histidine residue for Tetracycline/H+ antiport function but not mandatory for full activity of the transposon Tn10-encoded metal-Tetracycline/H+ antiporter.
Biochemistry 35, 4359-4364 (1996)
abstract