The Institute of Scientific and Industrial Research, Osaka University

ISIR OSAKA UNIVERSITY

Division of Biological and Molecular Sciences

Department of Biomolecular Science and Regulation

Staff

K.NISHINO
  • Prof.
    K.NISHINO
T.NISHI
  • Assoc. Prof.
    T.NISHI
S.YAMASAKI
  • Assis. Prof.
    S.YAMASAKI
M.NISHINO
  • Assis. Prof.
    M.NISHINO
ZWAMA MARTIJN
  • Specially Appointed Assis. Prof.
    ZWAMA MARTIJN

Content of research

Xenobiotic transporters are widely distributed in living organisms and play important roles in their self-defense mechanisms. Transporters cause a serious chemotherapeutic problem named multidrug resistance in pathogenic bacteria and cancer cells. Recent discoveries also support the notion that some xenobiotic transporters have shown to have important roles in bacterial virulence and signal transduction. We are interested in understanding roles xenobiotic transporters in multidrug resistance and physiological functions. Our knowledge should promote the development of novel inhibitors or strategies that could counteract the contribution of xenobiotic transporters to drug resistance and virulence.

Current Research Programs

  • 1. Development of therapeutic strategies to control infectious diseases
    2. Regulation and physiological function of xenobiotic transporters
    3. Nanosystems biology of multidrug resistance
    4. Development of new devices to detect multidrug resistant bacteria
    5. 3D imaging of bio-nanostructures by electron tomography
    6. Morphological analysis and identification of multidrug resistant bacteria by deep learning

Figure / Graph

図1.多剤耐性のナノシステムバイオロジー
  • Fig.1. Nanosystems biology of multidrug resistance. Science (2005), Proc. Natl. Acad. Sci. USA (2005, 2013), Mol. Microbiol. (2006), J. Biol. Chem. (2008, 2011), Nature (2011), Nature (2013), Nature Commun. (2013)
図2.マウスSPNS2は血管内皮細胞に発現してリンパ球の血中移行を制御する
  • Fig.2. Mouse SPNS2 expressed on vascular endothelial cells regulates lymphocyte egress into blood. Science (2009), J. Biol. Chem. (2011), PLoS One (2012)

VIDEO INTRODUCTION