The Institute of Scientific and Industrial Research, Osaka University

ISIR OSAKA UNIVERSITY

Division of Biological and Molecular Sciences

Department of Biomolecular Science and Engineering

Staff

T.NAGAI
  • Prof.
    T.NAGAI
T.MATSUDA
  • Assoc. Prof.
    T.MATSUDA
M.HATTORI
  • Assis. Prof.
    M.HATTORI
K.OSABE
  • Assis. Prof.
    K.OSABE
T.ENTANI
  • Specially Appointed Assis. Prof.
    T.ENTANI

Content of research

What is life? To approach this simple but profound theme, in our laboratory, we research to observe and understand the molecular phenomena within a live cell, by bio-imaging. Specifically, we isolate the genes coding for luminescent proteins from light emitting organisms, and develop bio-sensors and imaging methods that will help understand life. These research will not only contribute to understand the fundamental phenomena of life, but also for medical purpose and drug discovery. In addition, we are developing technologies that can lead to innovative changes of our future society, such as electricity-free illumination system by inserting the genes coding for light emitting proteins into plant.

Current Research Programs

  • 1. Development of novel fluorescent/bioluminescent protein-based indicators for biological events
    2. Application of protein 3D structural information to development of novel indicators
    3. Development of techniques for light-based manipulation of protein and cellular activity
    4. Development of optical microscope technology enabling whole-organism imaging
    5. Spying minority in biological phenomena

Figure / Graph

図1. 光スイッチング蛍光タンパク質Kohinoorを用いた超解像イメージング
  • Fig1. Superresolution imaging using photoswitchable protein Kohinoor
図2. 発光タンパク質 eNano-Lantern による生きたHeLa細胞の5色発光イメージング
  • Fig2. Five-color luminescence imaging of HeLa cell by luminescent protein eNano-Lantern
図3. 3色の発光タンパク質を発現させたゼニゴケ
  • Fig3. Marchantia expressing three-color luminescent protein

VIDEO INTRODUCTION