Yasunobu Yamashita

Assistant Professor: Yasunobu Yamashita, Ph.D

Room:1st Building F-527, The Institute of Scientific and Industrial Research, Osaka University

TEL:06-6879-8471 (8471)

Mail: yyamashita[at]sanken.osaka-u.ac.jp

 

Education

2008-2012  B.S. in Faculty of Pharmacy, Keio University
2012-2014  M.S. in Graduate School of Pharmaceutical Sciences, Keio University
2014-2017  Ph.D. in Graduate School of Pharmaceutical Sciences, Keio University

Research

2015.04-2017.03  JSPS Research Fellowships for Young Scientists (DC2)
2017.04-2017.07  Post-doctoral researcher at Technology Research Association for Next-Generation Natural Products Chemistry
2017.08-2018.03  Post-doctoral researcher at Bielefeld University, Germany (ONE-FLOW Project)
2018.03-2019.12  Post-doctoral researcher at Bielefeld University, Germany (supported by Alexander von Humboldt foundation)

Original papers
  1. Learning about enzyme stability against organic co-solvents from structural insight by ion mobility mass spectrometry.
    Jens Sproß, Yasunobu Yamashita, Harald Gröger
    ChemBioChem, in press.
  2. Metalloprotein-catalyzed click reaction for In situ generation of a potent inhibitor.
    Yuka Miyake, Yukihiro Itoh, Yoshinori Suzuma, Hidehiko Kodama, Takashi Kurohara, Yasunobu Yamashita, Remy Narozny, Yutaro Hanatani, Shusaku Uchida, Takayoshi Suzuki. ACS Catal., 2020, 10, 5383.
  3. Chemical modification-mediated optimization of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity.
    Yasunobu Yamashita, Ken-Ichiro Tanaka, Naoki Yamakawa, Teita Asano, Yuki Kanda, Ayaka Takafuji, Masahiro Kawahara, Mitsuko Takenaga, Yoshifumi Fukunishi, Tohru Mizushima
    Bioorg. Med. Chem., 2019, 27, 3339.
  4. An asymmetric organocatalytic aldol reaction of a hydrophobic aldehyde in aqueous medium running in flow mode
    Lukas Schober, Shahilan Ratnam, Yasunobu Yamashita, Niklas Adebar, Matthias Pieper, Albrecht Berkessel, Volker Hessel, Harald Gröger
    Synthesis, 2019, 51,
  5. Identification of mepenzolate derivatives with long-acting bronchodilatory activity.
    Ken-Ichiro Tanaka, Naoki Yamakawa, Yasunobu Yamashita, Teita Asano, Yuki Kanda, Ayaka Takafuji, Masahiro Kawahara, Mitsuko Takenaga, Yoshifumi Fukunishi, Tohru Mizushima
    Frontiers in Pharmacology, 2018, 9, 344.
  6. Prediction of protein-compound binding energies from known activity data: docking-score-based method and its applications
    Yoshifumi Fukunishi, Yasunobu Yamashita, Tadaaki Mashimo, Haruki Nakamura
    Mol. Inf., 2018, 37, 1700120.
  7. Short-step syntheses of naturally occurring polyoxygenated aromatics based on site-selective
    Yasunobu Yamashita, Alan Biard, Kengo Hanaya, Mitsuru Shoji, Takeshi Sugai
    Biosci. Biotechnol. Biochem., 2017, 81, 1279.
  8. Preparation of (R)-3-hydroxy-N-methylpiperidine, a synthetic key intermediate of (R)-mepenzolate, based on the lipase-catalyzed resolution of the racemic form.
    Yasunobu Yamashita, Kengo Hanaya, Mitsuru Shoji, Takeshi Sugai
    Heterocycles, 2017, 95, 370.
  9. Simple synthesis of sakuranetin and selinone via common intermediate, utilizing complementary regioselectivity in the deacetylation of naringenin triacetate.
    Yasunobu Yamashita, Kengo Hanaya, Mitsuru Shoji, Takeshi Sugai
    Chem. Pharm. Bull., 2016, 64, 961.
  10. Ex situ enantioconvergent approaches for effective use of undesired isomers: stereochemical convergence of substrates with multiple chiral centers and recycling of decarboxylated byproduct.
    Yasunobu Yamashita, Tohru Kurihara, Takanobu Horiguchi, Atsushi Miki, Mitsuru Shoji, Takeshi Sugai, Kengo Hanaya
    Synthesis, 2016, 48, 2191.
  11. Recent advances for synthesis of scyphostatin and utilization of oxabicyclo[2.2.1]heptane toward ethyl shikimate.
    Kazuaki Kuwata, Yasunobu Yamashita, Kengo Hanaya, Takeshi Sugai, Tohru Mizushima, Mitsuru Shoji
    Studies in Natural Products Chemistry, 2016, 47, 387.
  12. Superiority of pulmonary administration of mepenzolate bromide over other routes as treatment for chronic obstructive pulmonary disease.
    Ken-Ichiro Tanaka, Shota Kurotsu, Teita Asano, Naoki Yamakawa, Daisuke Kobayashi, Yasunobu Yamashita, Hiroshi Yamazaki, Tomoaki Ishihara, Hiroshi Watanabe, Toru Maruyama, Hidekazu Suzuki, Tohru Mizushima
    Scientific Report, 2014, 4, 1.
  13. Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activit
    Yasunobu Yamashita, Ken-Ichiro Tanaka, Teita Asano, Naoki Yamakawa, Daisuke Kobayashi, Tomoaki Ishihara, Kengo Hanaya, Mitsuru Shoji, Takeshi Sugai, Mitsuhito Wada, Tadaaki Mashimo, Yoshifumi Fukunishi, Tohru Mizushima
    Bioorg. Med. Chem., 2014, 22, 3488.
  14. Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity.
    Naoki Yamakawa, Koichiro Suzuki, Yasunobu Yamashita, Takashi Katsu, Kengo Hanaya, Mitsuru Shoji, Takeshi Sugai, Tohru Mizushima
    Bioorg. Med. Chem., 2014, 22, 2529.
  15. Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease.
    Ken-Ichiro Tanaka, Tomoaki Ishihara, Toshifumi Sugizaki, Daisuke Kobayashi, Yasunobu Yamashita, Kayoko Tahara, Naoki Yamakawa, Kumiko Iijima, Kaoru Mogushi, Hiroshi Tanaka, Keizo Sato, Hidekazu Suzuki, Tohru Mizushima
    Nature Communications, 2013, 4, 2686.
  16. Prostaglandin E1-encapsulated nanoparticles improve walking activity in an experimental rat model of intermittent claudication.
    Tomoaki Ishihara, Yasunobu Yamashita, Naoko Takasaki, Shuhei Yamamoto, Erika Hayashi, Kayoko Tahara, Mitsuko Takenaga, Naoki Yamakawa, Tsutomu Ishihara, Tadashi Kasahara, Tohru Mizushima
    Pharm. Pharmacol., 2013, 65, 1187.
  17. Chemo-enzymatic enantioconvergent approach toward ethyl shikimate from ethyl 5-hydroxy-3,4-isopropylidenedioxycyclohex-1-enecarboxylate.
    Yasunobu Yamashita, Kengo Hanaya, Takeshi Sugai, Tohru Mizushima, Mitsuru Shoji
    Tetrahedron, 2013, 69, 6527.
Book
  1. Yasunobu Yamashita, Harald Gröger, in Science of Synthesis: Dual Catalysis in Organic Synthesis (Hrsg.: G. A. Molander), Vol. 2, Thieme, Stuttgart, 2019, chapter 2.5, p. 339-364.
Patent
  1. Tohru Mizushima, Yasunobu Yamashita, Naoki Yamakawa
    Quinuclidine Derivative.
    Publication No. WO2016140136