黒原 崇

特任助教  Takashi Kurohara

大阪大学 産業科学研究所 黒原崇居室:大阪大学 産業科学研究所 第1研究棟 5階 F-527

TEL:06-6879-8471

Mail: t.kurohara[at]sanken.osaka-u.ac.jp

researchmap, 研究者番号:90865776
HP管理者

 

履歴

2015–2018 名古屋大学 大学院創薬科学研究科 博士(創薬科学) 山本芳彦 教授
2013–2015 名古屋大学 大学院創薬科学研究科 修士(創薬科学) 山本芳彦 教授
2007–2013 九州保健福祉大学 薬学部 薬学科 学士(薬学)・薬剤師

研究歴
2018.4–2019.5 京都府立医科大学 大学院医学研究科 博士研究員
2019.6–2019.8 大阪大学 産業科学研究所 特任研究員
2019.8–現在        大阪大学 産業科学研究所 特任助教
原著論文
  1. ”Discovery of novel tetrahydrobenzo[b]thiophene-3-carbonitriles as histone deacetylase inhibitors”
    Piyush Gediya, Vivek K. Vyas, Vincenzo Carafa, Nikum Sitwala, Laura Della Torre, Angelita Poziello, Takashi Kurohara, Takayoshi Suzuki, Vinod Sanna, Varalakshmi Raguraman, K. Suthindhiran, Debarpan Ghosh, Dhiraj Bhatia, Lucia Altucci, Manjunath D. Ghate
    Bioorg. Chem. 2021, in press.
  2. ”Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders”
    Tetsuya Iida, Yukihiro Itoh, Yukari Takahashi, Yasunobu Yamashita, Takashi Kurohara, Yuka Miyake, Makoto Oba, Takayoshi Suzuki
    ChemMedChem 2021, in press.
  3. ”Metalloprotein-Catalyzed Click Reaction for In Situ Generation of a Potent Inhibitor”
    Yuka Miyake, Yukihiro Itoh, Yoshinori Suzuma, Hidehiko Kodama, Takashi Kurohara, Yasunobu Yamashita, Remy Narozny, Yutaro Hanatani, Shusaku Uchida, Takayoshi Suzuki.
    ACS Catal. 2020, 10, 5383–5392.
  4. ”Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the “Selectivity Pocket”, Substrate-Binding Site, and NAD+-Binding Site”
    Mellini Paolo, Yukihiro Itoh, Elboray Elghareeb, Hiroki Tsumoto, Ying Li, Miki Suzuki, Yukari Takahashi, Toshifumi Tojo, Takashi Kurohara, Yuka Miyake, Yuri Miura, Yuki Kitao, Masayuki Kotoku, Tetsuya Iida, Takayoshi Suzuki
    J. Med. Chem. 2019, 62, 5844-5862.
  5. ”N+-C-H···O Hydrogen Bonds in Protein-Ligand Complexes”
    Yukihiro Itoh, Yusuke Nakashima, ShuichiroTsukamoto, Takashi Kurohara, Miki Suzuki, Yoshitake Sakae, Masayuki Oda, YukoOkamoto, Takayoshi Suzuki
    Sci. Rep. 2019, 9, 767.
  6. “Identification of Ortho-Hydroxy Anilide as a Novel Scaffold for Lysine Demethylase 5 Inhibitors”
    Pattaporn Jaikhan, Benjaporn Buranrat, Yukihiro Itoh, Jiranan Chotitumnavee, Takashi Kurohara, Takayoshi Suzuki
    Bioorg. Med. Chem. Lett. 2019, 29, 1173–1176.
  7. “Synthesis of γ-Difluoromethylated Tetronate Derivatives from Squarates Using Difluoromethylphosphonate”
    Yoshihiko Yamamoto, Yuki Ishida, Takashi Kurohara, Masatoshi Shibuya, Takeshi Yasui
    Heterocycles 2019, 99, 363–378.
  8. “Synthesis of Alkoxycarbonyldifluoromethyl-Substituted Semisquarates and Their Transformations”
    Takashi Kurohara, Jiang Jiyue, Masatoshi Shibuya, Yoshihiko Yamamoto
    Synthesis 2018, 50, 1687–1698.
  9. “Synthesis of γ-Trifuluoromethyl Tetronate Derivatives from Squarates”
    Yoshihiko Yamamoto, Yosuke Takamizu, Takashi Kurohara, Masatoshi Shibuya
    Heterocycles 2017, 95, 525–539.
  10. “Electrophilic Derivatizations of Trifluoromethyl-Substituted Semisquarate Using Unsaturated Organosilanes and Subsequent Ring Transformations”
    Takashi Kurohara, Masatoshi Shibuya, Yoshihiko Yamamoto
    Adv. Synth. Catal. 2017, 359, 1413–1419.
  11. “CF3-Substituted Semisquarate: A Pluripotent Building Block for the Divergent Synthesis of Trifluoromethylated Functional Molecules”
    Yoshihiko Yamamoto, Takashi Kurohara, Masatoshi Shibuya
    Chem. Commun. 2015, 51, 16357–16360.
  12. “Synthesis of β-Allylbutenolides via One-Pot Copper-Catalyzed Hydroallylation/Cyclization of γ-Hydroxybutynoate Derivatives”
    Yoshihiko Yamamoto, Shinya Shibano, Takashi Kurohara, Masatoshi Shibuya
    J. Org. Chem. 2014, 79, 4503–4511.
総説
  1. Yukihiro Itoh, Takashi Kurohara, Takayoshi Suzuki. N+-C-H…O Hydrogen Bonds in Protein-Ligand Complexes and their Application to Drug Design. Journal of Synthetic Organic Chemistry Japan, 78, 71151-1162, 2020.
特許
  1. 「炎症性腸疾患処置剤」
    長谷耕二、高橋大輔、鈴木 孝禎、黒原 崇、上田 聡、田中 啓太
    特願2020-064635.
  2. 「トリフルオロメチル置換セミスクアレートの製造方法、トリフルオロメチル置換セミスクアレートを起点とするトリフルオロメチル化合物の製造方法及びトリフルオロメチル基含有化合物」
    山本芳彦,黒原崇,澁谷正俊
    特願2015-116151,特願2015-150175, WO/2016/199789 (PCT/JP2016/066988).