山下 泰信

助教  山下 泰信

居室:大阪大学 産業科学研究所 第1研究棟 5階 F-527

TEL:06-6879-8471 内線(8471)

Mail: yyamashita[at]sanken.osaka-u.ac.jp

 

学歴

2008-2012  慶應義塾大学 薬学部 薬科学科 学士 (薬科学)
2012-2014  慶應義塾大学大学院 薬学研究科 修士 (薬科学)
2014-2017  慶應義塾大学大学院 薬学研究科 博士 (薬科学)

研究歴

2015.04-2017.03  日本学術振興会特別研究員(DC2)
2017.04-2017.07  次世代天然物化学技術研究組合
2017.08-2018.03  ドイツ・Bielefeld大学特別研究員(ONE FLOW PROJECT)
2018.03-2019.12  ドイツ・Bielefeld大学特別研究員 (フンボルト財団)
2020.01-                  大阪大学産業科学研究所助教

原著論文
  1. Identification of novel histone deacetylase 6-selective inhibitors bearing 3,3,3-trifluorolactic amide (TFLAM) motif as a zinc binding group.
    Takashi Kurohara, Keita Tanaka, Daisuke Takahashi, Satoshi Ueda, Yasunobu Yamashita, Yuri Takada, Hirokazu Takeshima, Shengwang Yu, Yukihiro Itoh, Koji Hase, Takayoshi Suzuki 
    ChemBioChem 202122, 3158-3163.
  2. Identification of Potent and Selective Inhibitors of Fat Mass Obesity Associated Protein Using a Fragment-Merging Approach.
    Muthuraj Prakash, Yukihiro Itoh, Yoshie Fujiwara,Yukari Takahashi, Yuri Takada, Paolo Mellini, Elghareeb E. Elboray, Mitsuhiro Terao, Yasunobu Yamashita, Chika Yamamoto, Takao Yamaguchi, Masayuki Kotoku, Yuki Kitao, Ritesh Singh, Rohini Roy, Satoshi Obika, Makoto Oba, Dan Ohtan Wang, and Takayoshi Suzuki
    J. Med. Chem202164, 15810–15824.
  3. Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5C Degraders.
    Tetsuya Iida, Yukihiro Itoh, Yukari Takahashi, Yasunobu Yamashita, Takashi Kurohara, Yuka Miyake, Makoto Oba, Takayoshi Suzuki.
    ChemMedChem 2021, 16, in press.
  4. Learning about enzyme stability against organic co-solvents from structural insight by ion mobility mass spectrometry.
    Jens Sproß, Yasunobu Yamashita, Harald Gröger
    ChemBioChem, 2020, 21, 1968-1971.
  5. Metalloprotein-catalyzed click reaction for In situ generation of a potent inhibitor.
    Yuka Miyake, Yukihiro Itoh, Yoshinori Suzuma, Hidehiko Kodama, Takashi Kurohara, Yasunobu Yamashita, Remy Narozny, Yutaro Hanatani, Shusaku Uchida, Takayoshi Suzuki
    ACS Catal., 2020, 10, 5383-5392.
  6. Chemical modification-mediated optimization of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity.
    Yasunobu Yamashita, Ken-Ichiro Tanaka, Naoki Yamakawa, Teita Asano, Yuki Kanda, Ayaka Takafuji, Masahiro Kawahara, Mitsuko Takenaga, Yoshifumi Fukunishi, Tohru Mizushima
    Bioorg. Med. Chem., 2019, 27, 3339-3346.
  7. An asymmetric organocatalytic aldol reaction of a hydrophobic aldehyde in aqueous medium running in flow mode
    Lukas Schober, Shahilan Ratnam, Yasunobu Yamashita, Niklas Adebar, Matthias Pieper, Albrecht Berkessel, Volker Hessel, Harald Gröger
    Synthesis, 2019, 51, 1178-1184.
  8. Identification of mepenzolate derivatives with long-acting bronchodilatory activity.
    Ken-Ichiro Tanaka, Naoki Yamakawa Yasunobu Yamashita, Teita Asano, Yuki Kanda, Ayaka Takafuji, Masahiro Kawahara, Mitsuko Takenaga, Yoshifumi Fukunishi, Tohru Mizushima
    Frontiers in Pharmacology, 2018, 9, 344.
  9. Prediction of protein-compound binding energies from known activity data: docking-score-based method and its applications
    Yoshifumi Fukunishi, Yasunobu Yamashita, Tadaaki Mashimo, Haruki Nakamura
    Mol. Inf., 2018, 37, 1700120.
  10. Short-step syntheses of naturally occurring polyoxygenated aromatics based on site-selective
    Yasunobu Yamashita, Alan Biard, Kengo Hanaya, Mitsuru Shoji, Takeshi Sugai
    Biosci. Biotechnol. Biochem., 2017, 81, 1279-1284.
  11. Preparation of (R)-3-hydroxy-N-methylpiperidine, a synthetic key intermediate of (R)-mepenzolate, based on the lipase-catalyzed resolution of the racemic form.
    Yasunobu Yamashita, Kengo Hanaya, Mitsuru Shoji, Takeshi Sugai
    Heterocycles, 2017, 95, 370-379.
  12. Simple synthesis of sakuranetin and selinone via common intermediate, utilizing complementary regioselectivity in the deacetylation of naringenin triacetate.
    Yasunobu Yamashita, Kengo Hanaya, Mitsuru Shoji, Takeshi Sugai
    Chem. Pharm. Bull., 2016, 64, 961-965.
  13. Ex situ enantioconvergent approaches for effective use of undesired isomers: stereochemical convergence of substrates with multiple chiral centers and recycling of decarboxylated byproduct.
    Yasunobu Yamashita, Tohru Kurihara, Takanobu Horiguchi, Atsushi Miki, Mitsuru Shoji, Takeshi Sugai, Kengo Hanaya
    Synthesis, 2016, 48, 2191-2200.
  14. Recent advances for synthesis of scyphostatin and utilization of oxabicyclo[2.2.1]heptane toward ethyl shikimate.
    Kazuaki Kuwata, Yasunobu Yamashita, Kengo Hanaya, Takeshi Sugai, Tohru Mizushima, Mitsuru Shoji
    Studies in Natural Products Chemistry, 2016, 47, 387.
  15. Superiority of pulmonary administration of mepenzolate bromide over other routes as treatment for chronic obstructive pulmonary disease.
    Ken-Ichiro Tanaka, Shota Kurotsu, Teita Asano, Naoki Yamakawa, Daisuke Kobayashi, Yasunobu Yamashita, Hiroshi Yamazaki, Tomoaki Ishihara, Hiroshi Watanabe, Toru Maruyama, Hidekazu Suzuki, Tohru Mizushima
    Scientific Report, 2014, 4, 1.
  16. Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activity.
    Yasunobu Yamashita, Ken-Ichiro Tanaka, Teita Asano, Naoki Yamakawa, Daisuke Kobayashi, Tomoaki Ishihara, Kengo Hanaya, Mitsuru Shoji, Takeshi Sugai, Mitsuhito Wada, Tadaaki Mashimo, Yoshifumi Fukunishi, Tohru Mizushima
    Bioorg. Med. Chem., 2014, 22, 3488-3497.
  17. Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity.
    Naoki Yamakawa, Koichiro Suzuki, Yasunobu Yamashita, Takashi Katsu, Kengo Hanaya, Mitsuru Shoji, Takeshi Sugai, Tohru Mizushima
    Bioorg. Med. Chem., 2014, 22, 2529.
  18. Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease.
    Ken-Ichiro Tanaka, Tomoaki Ishihara, Toshifumi Sugizaki, Daisuke Kobayashi, Yasunobu Yamashita, Kayoko Tahara, Naoki Yamakawa, Kumiko Iijima, Kaoru Mogushi, Hiroshi Tanaka, Keizo Sato, Hidekazu Suzuki, Tohru Mizushima
    Nature Communications, 2013, 4, 2686.
  19. Prostaglandin E1-encapsulated nanoparticles improve walking activity in an experimental rat model of intermittent claudication.
    Tomoaki Ishihara, Yasunobu Yamashita, Naoko Takasaki, Shuhei Yamamoto, Erika Hayashi, Kayoko Tahara, Mitsuko Takenaga, Naoki Yamakawa, Tsutomu Ishihara, Tadashi Kasahara, Tohru Mizushima
    Pharm. Pharmacol., 2013, 65, 1187.
  20. Chemo-enzymatic enantioconvergent approach toward ethyl shikimate from ethyl 5-hydroxy-3,4-isopropylidenedioxycyclohex-1-enecarboxylate.
    Yasunobu Yamashita, Kengo Hanaya, Takeshi Sugai, Tohru Mizushima, Mitsuru Shoji
    Tetrahedron, 2013, 69, 6527-6532.
著書
  1. Yasunobu Yamashita, Harald Gröger, in Science of Synthesis: Dual Catalysis in Organic Synthesis (Hrsg.: G. A. Molander), Vol. 2, Thieme, Stuttgart, 2019, chapter 2.5, p. 339-364.
特許
  1. Tohru Mizushima, Yasunobu Yamashita, Naoki Yamakawa
    Quinuclidine Derivative.
    Publication No. WO2016140136
賞罰
  1. 2015年3月 日本薬学会 第 135 年会優秀発表賞
  2. 2018年5月 アレキサンダー・フォン・フンボルト財団 ポストドクトラルフェロー
その他(依頼記事等)
  1. 山下泰信 μ-オピオイド受容体選択的蛍光プローブを用いた1分子イメージング ファルマシア 2020, 56, 955.