2024
Yamasaki, S., N. Koga, R. Nakashima, M. Hayashi-Nishino, and K. Nishino. (2024) Point mutation analysis of the drug efflux pump MexB in clinical isolates of Pseudomonas aeruginosa. Biol. Pharm. Bull., in press.
Ikebe, M., K. Aoki, M. Hayashi-Nishino, C. Furusawa, and K. Nishino. (2024) Bioinformatic analysis reveals the association between bacterial morphology and antibiotic resistance using light microscopy with deep learning. Front. Microbiol.15, 1450804.
Taguchi, A., R. Nakashima, and K. Nishino. (2024) Structural basis of nucleotide selectivity in pyruvate kinase. J. Mol. Biol. 436, 168708.
Murahashi, T., J. Yamagishi, T. Igarashi, M. Kawai, S. Yamasaki, K. Nishino, and T. Higuchi. (2024) Evaluation of pharmaceutical concentrations and antimicrobial activity in river water from the Tone River system in Gunma Prefecture, Japan. Fundam. Toxicol. Sci. 11, 149-157.
Harada, A., M. Kunii, K. Kurokawa, T. Sumi, S. Kanda, Y. Zhang, S. Nadanaka, K.M. Hirosawa, K. Tokunaga, T. Tojima, M. Taniguchi, K. Moriwaki, S.I. Yoshimura, M. Yamamoto-Hino, S. Goto, T. Katagiri, S. Kume, M. Hayashi-Nishino, M. Nakano, E. Miyoshi, K.G.N. Suzuki, H. Kitagawa, and A. Nakano. (2024) Dynamic movement of the Golgi unit and its glycosylation enzyme zones. Nature Commun. 15, 4154.
Giraud, E., S. Baucheron, I. Foubert, B. Doublet, K. Nishino, and A. Cloeckaert. (2024) Major primary bile salts repress Salmonella enterica serovar Typhimurium invasiveness partly via the efflux regulatory locus ramRA. Front. Microbiol. 15, 1338261.
Matsumoto Y., S. Yamasaki, K. Hayama, R. Iino, H. Noji, A. Yamaguchi, and K. Nishino. (2024) Changes in the expression of mexB, mexY, and oprD in clinical Pseudomonas aeruginosa isolates. Proc. Jpn. Acad., Ser. B, Phys. 100, 57-67.
山崎聖司、古閑修輝、細見拓郎、Martijn Zwama、Chaiyanut Jirayupat、柳田剛、西野邦彦. (2024) 放出化合物の測定による細菌性状の迅速分析 (Acethylcholine-dependent signal transduction for aversive learning). BIO Clinica, 39(6), (503) 59-(506) 62.
山崎聖司、古閑修輝、細見拓郎、Martijn Zwama、Chaiyanut Jirayupat、柳田剛、西野邦彦. (2024) 細菌由来疾患の予防及び早期検出に向けた細菌放出化合物測定法の開発 (Development of a bacterial release compound assay for prevention and early detection of bacteria-derived diseases). Medical Science Digest, 50(3), 41(153)-43(155). 通巻660号（2024年3月25日発行）
2023
Yamamura, R., K. Y. Inoue, K. Nishino, and S. Yamasaki. (2023) Intestinal and fecal pH in human health. Front. Microbiomes 2, 1192316.
Taguchi, A., R. Nakashima, and K. Nishino. (2023) Functional and structural characterization of Streptococcus pneumoniae pyruvate kinase involved in fosfomycin resistance. J. Biol. Chem. 299, 104892.
Yamasaki, S.,M. Zwama, T. Yoneda, M. Hayashi-Nishino, and K. Nishino. (2023) Drug resistance and physiological roles of RND multidrug efflux pumps in Salmonella enterica, Escherichia coli, and Pseudomonas aeruginosa. Microbiology 169, 001322.
Yamasaki, S.,T. Yoneda, S. Ikawa, M. Hayashi-Nishino, and K. Nishino. (2023) Investigating multidrug efflux pumps associated with fatty acid salt resistance in Escherichia coli. Front. Microbiol.14, 954304.
Liu, Z., Y. Okada, Y. Ichinose, D. Saitoh, N. Ieda, S. Yamasaki, K. Nishino, H. Nakagawa, M. Fujitsuka, and Y. Osakada. (2023) Vanadyl naphthalocyanine-doped polymer dots for near-infrared light-induced nitric oxide release and bactericidal effects. ACS Appl. Nano. Mater. 6, 1487-1495.
Satoh, A., M. Hayashi-Nishino, and K. Nishino. (2023) An electron tomographic analysis of giantin-deficient golgi proposes a new function of the golgin protein family. Methods Mol. Biol. 2557, 235-246.
西野—林美都子、青木工太、西野邦彦. (2023) AIによる薬剤耐性菌の画像判別 (The Application of artificial intelligence in the recognition of drug-resistant bacterial images). 細胞 (Cell) 55(13), (1082)72-(1084)74. 2023年11月号（2023年10月20日刊行）
山崎聖司、Martijn Zwama、古閑修輝、櫻井啓介、中島良介、山口明人、西野邦彦. (2023) 緑膿菌の多剤排出トランスポーターにおける阻害剤結合部位の包括的解析 (Comprehensive analysis of the binding site for efflux transporter inhibitors in Pseudomonas aeruginosa). BIO Clinica 38(6), 536-540.
西野邦彦. (2023) 多剤耐性菌感染症克服を目指して（研究室紹介）. 生産と技術 75 (1), 41-45.
2022
Yamasaki, S., N. Koga, M. Zwama, K. Sakurai, R. Nakashima, A. Yamaguchi, and K. Nishino. (2022) Spatial characteristics of the efflux pump MexB determine inhibitor binding. Antimicrob. Agents Chemother. 66, e00672-22.
Murahashi, T., J. Yamagishi, K. Nishino, R. Takada, T. Sekine, Y. Matsuda, and T. Higuchi. (2022) Pharmaceutical concentrations and antimicrobial activity using hypersusceptible Escherichia coli lacking TolC component of multidrug efflux system in Ayase River in Japan. Fundam. Toxicol. Sci. 9, 187-196.
Fujiwara, M., S. Yamasaki, Y. Morita, and K. Nishino. (2022) Evaluation of efflux pump inhibitors of MexAB- or MexXY-OprM in Pseudomonas aeruginosa using nucleic acid dyes. J. Infect. Chemother. 28, 595-601.
Zwama, M. and K. Nishino. (2022) Proximal binding pocket Arg717 substitutions in Escherichia coli AcrB cause clinically relevant divergencies in resistance profiles. Antimicrob. Agents Chemother. 66, e0239221.
Hayashi-Nishino, M., K. Aoki, A. Kishimoto, Y. Takeuchi, A. Fukushima, K. Uchida, T. Echigo, Y. Yagi, M. Hirose, K. Iwasaki, E. Shin’ya, T. Washio, C. Furusawa, and K. Nishino. (2022) Identification of bacterial drug-resistant cells by the convolutional neural network in transmission electron microscope images. Front. Microbiol.13, 839718.
Yoneda, T., H. Sakata, S. Yamasaki, M. Hayashi-Nishino, and K. Nishino. (2022) Analysis of multidrug efflux transporters in resisntace to fatty acid salts reveals a TolC-independent function of EmrAB in Salmonella enterica. PLoS One. 17, e0266806.
Müller, A., K. Sakurai, D. Seinige, K. Nishino, and C. Kehrenberg. (2022) Mutations in the phenicol exporter gene fexA impact resistance levels in three bacterial hosts according to susceptibility testing and protein modeling. Front. Microbiol. 12, 794435.
西野—林美都子、青木工太、西野邦彦. (2022) 深層学習によって薬剤耐性菌の形態特徴を可視化する（目で見るバイオ）. バイオサイエンスとインダストリー 80, 374-375.
西野—林美都子、青木工太、西野邦彦. (2022) 深層学習を用いた画像解析による薬剤耐性菌の判別（トピックス）. バイオサイエンスとインダストリー 80, 402-403.
山崎聖司、Martijn Zwama、古閑修輝、櫻井啓介、中島良介、山口明人、西野邦彦. (2022) 新薬開発に向けた細菌多剤排出トランスポーターの阻害剤結合ピットの解析 (Inhibitor binding pits analysis of bacterial multidrug efflux transporters for new drug development). Precision Medicine, 5(14), (1310)56-(1314)60. 通巻59号（2022年11月26日発行）
(Preprint)
Ikawa, S., S. Yamasaki, Y. Morita, and K. Nishino. (2022) Role of the drug efflux pump in the intrinsic cefiderocol resistance of Pseudomonas aeruginosa.
doi: https://www.biorxiv.org/content/10.1101/2022.05.31.494263v1
2021
Nishino, K., S. Yamasaki, R. Nakashima, M. Zwama, and M. Hayashi-Nishino. (2021) Function and inhibitory mechanisms of multidrug efflux pumps. Front. Microbiol. 12, 737288.
Zwama, M. and K. Nishino. (2021) Ever-adapting RND efflux pumps in Gram-negative multidrug resistant pathogens: A race against time. Antibiotics 10, 774. In Special Issue “The structural and functional study of efflux pumps belonging to the RND transporters family from Gram-negative bacteria”.
(Preprint)
Zwama, M. and K. Nishino. Proximal binding pocket Arg717 substitutions in Escherichia coli AcrB cause clinically relevant divergencies in resistance profiles.
doi: https://doi.org/10.1101/2021.12.16.473095
Hayashi-Nishino, M., K. Aoki, A. Kishimoto, Y. Takeuchi, A. Fukushima, K. Uchida, T. Echigo, Y. Yagi, M. Hirose, K. Iwasaki, E. Shin’ya, T. Washio, C. Furusawa, and K. Nishino. Identification of bacterial drug-resistant cells by the convolutional neural network in transmission electron microscope images.
doi: https://doi.org/10.1101/2021.10.19.464925
2020
Koga, N., T. Hosomi, M. Zwama, C. Jirayupat, T. Yanagida, K. Nishino, and S. Yamasaki. (2020) Identification of genetic variants via bacterial respiration gas analysis. Front. Microbiol. 11, 58171. doi: 10.3389/fmicb.2020.581571
Harada, T., R. Sada, Y. Osugi, S. Matsumoto, T. Matsuda, M. Hayashi-Nishino, T. Nagai, A. Harada, and A. Kikuchi. Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER-mitochondria contact sites. J. Cell. Sci. 133, jcs249045. doi: 10.1242/jcs.249045
Yamagishi, A., S. Nakano, S. Yamasaki, and K. Nishino. (2020) An efflux inhibitor of the MacAB pump in Salmonella enterica serovar Typhimurium. Microbiol. Immunol. 64, 182-188.
西野邦彦、山崎聖司、中島良介. (2020) 多剤排出ポンプの機能と阻害機構. 膜タンパク質工学ハンドブック(第１編 膜タンパク質の基礎 第２章 構造・物性・分析・解析 第１３節), 83-92.（2020年4月発行）
山崎聖司、 Martijn Zwama、 中島良介、山口明人、西野邦彦. (2020) タンパク質構造情報を利用した細菌多剤排出トランスポーターの機能解析 (Structure based functional analysis of bacterial multidrug efflux transporters). BIO Clinica 35(2), 155-160.（2020年1月10日発行）
2019
Xu, Z., M. Li, Y. Li, H. Cao, L. Miao, Z. Xu, Y. Higuchi, S. Yamasaki, K. Nishino, P. C. Y. Woo, H. Xiang, and A. Yan. (2019) Native CRISPR-Cas enables dissecting and sensitizing clinical multidrug resistant P. aeruginosa. Cell Rep. 29, 1707-1717.
Kotani, K., M. Mtsumura, Y. Morita, J. Tomida, R. Kutsuna, K. Nishino, S. Yasuike, and Y. Kawamura. (2019) 13-(2-Methylbenzyl) Berberine is a more potent inhibitor of MexXY-dependent aminoglycoside resistance than berberine. Antibiotics 8, 212.
Zwama, M., A. Yamaguchi, and K. Nishino. (2019) Phylogenetic and functional characterisation of the Haemophilus influenzae multidrug efflux pump AcrB. Commun. Biol. 2, 340.
Matsumoto, T., R. Nakashima, A. Yamano, and K. Nishino. (2019) Development of organic compounds structure determination method using multidrug-resistance regulator protein as a framework. Biochem. Biophys. Res. Commun. 518, 402-408.
Satoh, A., M. Hayashi-Nishino, T. Shakuno, J. Masuda, M. Koreishi, R. Murakami, Y. Nakamura, T. Nakamura, N. Abe-Kanoh, Y. Honjo, J. Malsam, S. Yu, and K. Nishino. (2019) The Golgin protein giantin regulates interconnections between golgi stacks. Front. Cell Dev. Biol. 7, 160.
Raspoet, R., V. Eeckhaut, K. Vermeulen, L. De Smet, Y. Wen, K. Nishino, F. Haesebrouch, R. Ducatelle, B. Devreese, and F. Van Immerseel. (2019) The Salmonella Enteritidis TolC outer membrane channel is essential for egg white survival. Poult. Sci. 98, 2281-2289.
Sakurai, K., S. Yamasaki, K. Nakao, K. Nishino, A. Yamaguchi, and R. Nakashima. (2019) Crystal structures of multidrug efflux pump MexB bound with high-molecular-mass compounds. Sci. Rep. 9, 4359.
Yamasaki, S., R. Nakashima, K. Sakurai, S. Baucheron, E. Giraud, B. Doublet, A. Cloeckaert, and K. Nishino. (2019) Crystal structure of the multidrug resistance regulator RamR complexed with bile acids. Sci. Rep. 9, 177.
山崎聖司、Martijn Zwama、中島良介、山口明人、西野邦彦. (2019) 抗菌薬耐性に寄与する細菌多剤排出トランスポーターの変異解析 (Mutational analysis of bacterial multidrug efflux transporters contributing to antibiotic resistance). Precision Medicine, 2(9), 856-861.（2019年7月25日発行）
山崎聖司、中島良介、山口明人、西野邦彦. (2019) 耐性菌パンデミックの回避に向けた細菌多剤排出トランスポーターの解析と阻害剤開発 (Analysis and inhibitor development against bacterial multidrug efflux transporters). BIO Clinica 34(2), (202)83-(206)90. 通巻447号（2019年2月10日発行）
2018
Zwama, M., S. Yamasaki, R. Nakashima, K. Sakurai, K. Nishino, and A. Yamaguchi. (2018) Multiple entry pathways within of the efflux transporter AcrB contribute to multidrug recognition. Nature Commun. 9, 124.
Nishino, K. (2018) Regulation of the expression of bacterial multidrug exporters by two-component signal transduction systems. Methods Mol. Biol. 1700, 239-251. In Bacterial Multidrug Exporters. Edited by Akihito Yamaguchi and Kunihiko Nishino (Springer)
Iino, R., S. Sakakihara, Y. Matsumoto, and K. Nishino. (2018) Large scale femtoliter droplet array for single cell efflux assay of bacteria. Methods Mol. Biol. 1700, 331-341. In Bacterial Multidrug Exporters. Edited by Akihito Yamaguchi and Kunihiko Nishino (Springer)
2017
Zwama, M., K. Hayashi, K. Sakurai, R. Nakashima, K. Kitagawa, K. Nishino, and A. Yamaguchi. (2017) Hoisting-loop in bacterial multidrug exporter AcrB is a highly flexible hinge that enables the large motion of the subdomains. Front. Microbiol. 8, 2095.
山崎聖司、林克彦、櫻井啓介、中島良介、山口明人、西野邦彦. (2017) グラム陰性菌の薬剤排出トランスポーター (Drug Efflux Transporters of Gram Negative Bacteria). 細胞 (Cell) 49(11), (533)7-(537)11. 2017年9月号（2017年8月20日刊行）
森田雄二、西野邦彦. (2017) 若手が拓く微生物薬学：多剤耐性菌と闘う (Frontier of pharmaceutical microbiology: To combat-resistant bacterial pathogens). 薬学雑誌 (Yakugaku Zasshi), 137, 371-372.
山崎聖司、中島良介、櫻井啓介、山口明人、西野邦彦. (2017) 耐性菌感染症の克服に向けた薬剤排出ポンプの構造解析と新規治療薬開発 (Structural analysis and new drug development against multidrug efflux pumps). 薬学雑誌 (Yakugaku Zasshi), 137, 377-382.
西野邦彦. (2017) 薬剤耐性における薬剤排出ポンプの役割 (Role of drug efflux pumps in bacterial drug resistance). 化学療法の領域 (Antibiotics & Chemotherapy) 33(5), (1029)79-(1039)89. 2017年5月号（第33巻 第5号）（2017年4月25日発行）
2016
Morita, Y., K. Nakashima, K. Nishino, J. Tomida, M. Inoue, and Y. Kawamura. (2016) Berberine is a novel type efflux inhibitor which attenuates the MexXY-mediated aminoglycoside resistance in Pseudomonas aeruginosa. Front. Microbiol. 7, 1223.
Nishino, K. (2016) Antimicrobial drug efflux pumps in Salmonella. In Efflux-Mediated Drug Resistance in Bacteria: Mechanisms, Regulation and Clinical Implications, Chapter 10. Edited by Xian-Zhi Li, Christopher A. Elkins and Helen I. Zgurskaya (Springer) 261-279.
Yamasaki, S., T. Fujioka, K. Hayashi, S. Yamasaki, M. Hayashi-Nishino, and K. Nishino. (2016) Phenotype microarray analysis of the drug efflux systems in Salmonella enterica serovar Typhimurium. J. Infect. Chemother. 22(11), 780-784.
Matsumoto, Y., S. Sakakihara, K. Kikuchi, A. Grushnikov, T. Kanade, H. Noji, A. Yamaguchi, R. Iino, Y. Yagi, and K. Nishino. (2016) A microfluidic channel method for rapid drug-susceptibility testing of Pseudomonas aeruginosa. PLoS One 11, e0148797.
Iino, R., S. Sakakihara, Y. Matsumoto, and K. Nishino. (2016) Single-cell detection and collection of persister bacteria in a directly accessible femtoliter droplet array. Methods Mol. Biol. 1333, 101-109. Springer Protocols. Bacterial Persistence. Edited by Jan Michiels and Maarten Fauvart.
2015
Hayashi, K., R. Nakashima, K. Sakurai, K. Kitagawa, S. Yamasaki, K. Nishino, and A. Yamaguchi. (2015) AcrB-AcrA fusion proteins that act as multidrug efflux transporters. J. Bacteriol. 198, 332-342.
Yamasaki, S., L. Y. Wang, T. Hirata, M. Hayashi-Nishino, and K. Nishino. (2015) Multidrug efflux pumps contribute to Escherichia coli biofilm maintenance. Int. J. Antimicrob. Agents, 44, 179-180. (DOI: http://dx.doi.org/10.1016/j.ijantimicag.2014.12.005)
Lin, J., K. Nishino, M. C. Roberts, M. Tolmasky, R. I. Aminov, and L. Zhang. (2015) Mechanisms of antibiotic resistance. Front. Microbiol. 6, 34. (DOI: 10.3389/fmicb.2015.00034)
山崎聖司、西野邦彦. (2015) 薬剤排出トランスポーターの分子生物学 (Molecular biology of multidrug efflux transporters). 化学療法の領域 (Antibiotics & Chemotherapy) 31(3), (433)101-(439)107. 2015 年3月号（第31巻 第3号）（2015年2月25日発行）
2014
Horiyama, T. and K. Nishino. (2014) AcrB, AcrD, and MdtABC multidrug efflux systems are involved in enterobactin export in Escherichia coli. PLoS One 9, e108642.
Rensch, U., K. Nishino, G. Klein, and C. Kehrenberg. (2014) Salmonella Typhimurium multidrug efflux pumps EmrAB and AcrEF support the major efflux system AcrAB in decreased susceptibility to triclosan. Int. J. Antimicrob. Agents 44, 179-180.
Baucheron, S., K. Nishino, I. Monchaux, S. Canepa, M. C. Maurel, F. Coste, A. Roussel, A. Cloeckaert, and E. Giraud. (2014) Bile-mediated activation of the acrAB and tolC multidrug efflux genes occurs mainly through transcriptional derepression of ramA in Salmonella enterica serovar Typhimurium. J. Antimicrob. Chemother. 69, 2400-2406. (doi: 10.1093/jac/dku140)
Hayashi, K., A. Fukushima, M. Hayashi-Nishino, and K. Nishino. (2014) Effect of methylglyoxal on multidrug-resistant Pseudomonas aeruginosa. Front. Microbiol. 5, 180. (doi: 10.3389/fmicb.2014.00180)
2013
Blair, J. M. A., A. Cloeckaert, K. Nishino, and L. J. V. Piddock. (2013) Alternative explanation for indole-induced antibiotic tolerance in Salmonella. Proc. Natl. Acad. Sci. USA. 110, E4569.
Iino, R., Y. Matsumoto, K. Nishino, A. Yamaguchi, and H. Noji. (2013) Design of a large-scale femtoliter droplet array for single-cell analysis of drug-tolerant and drug resistant bacteria. Front. Microbiol. 4, 300.
Yamaguchi, M., Y. Terao, Y. Mori-Yamaguchi, H. Domon, Y. Sakaue, T. Yagi, K. Nishino, A. Yamaguchi, V. Nizet, and S. Kawabata. (2013) Streptococcus pneumoniae invades erythrocytes and utilizes them to evade human innate immunity. PLoS One 8, e77282.
Nakashima, R., K. Sakurai, S. Yamasaki, K. Hayashi, C. Nagata, K. Hoshino, Y. Onodera, K. Nishino, and A. Yamaguchi. (2013) Structural basis for the inhibition of bacterial multidrug exporters. Nature 500, 102-106. (DOI 10.1038/nature12300)
Yamasaki, S., E. Nikaido, R. Nakashima, K. Sakurai, D. Fujiwara, I. Fujii, and K. Nishino. (2013) The crystal structure of multidrug-resistance regulator RamR with multiple drugs. Nature Commun. 4, 2078. (DOI: 10.1038/ncomms3078)
Yamasaki, S., S. Nagasawa, A. Fukushima, M. Hayashi-Nishino, and K. Nishino. (2013) Cooperation of the multidrug efflux pump and lipopolysaccharides in the intrinsic antibiotic resistance of Salmonella enterica serovar Typhimurium. J. Antimicrob. Chemother. 68, 1066-1070.
Giraud, E., S. Baucheron, I. Virlogeux-Payant, K. Nishino, and A. Cloeckaert. (2013) Effects of natural mutations in the ramRA locus on invasiveness of epidemic fluoroquinolone-resistant Salmonella enterica serovar Typhimurium isolates. J. Infect. Dis. 207, 794-802.
西野邦彦. (2013) 薬剤排出トランスポーターの機能と制御 (Regulation and function of drug efflux transporters). 化学療法の領域 (Antibiotics & Chemotherapy) 29, 81-89.
2013 年1月号（第29巻 第1号）（2012年12月25日発行）
Nishino, K. (2013) Multidrug efflux pumps and development of therapeutic strategies to control infectious diseases. Chembiomolecular Science, Part3, 269-279.
Edited by Masakatsu Shibasaki, Masamitsu Iino and Hiroyuki Osada (Springer)
Tabata, K., M. Hayashi-Nishino, T. Noda, A. Yamamoto, and T. Yoshimori. (2013) Morphological analysis of autophagy. Methods Mol. Biol., 931, 449-466.
その他著書等
西野邦彦. (2013) 薬剤排出ポンプの生理機能解明 (Physiological functions of drug efflux pumps). 薬学研究の進歩 (Advances in Pharmaceutical Sciences) 29, 27-31.
2012
Niu, H., Q. Xiong, A. Yamamoto, M. Hayashi-Nishino, and Y. Rikihisa. (2012) Autophagosomes induced by a bacterial Beclin 1 binding protein facilitate obligatory intracellular infection. Proc. Natl. Acad. Sci. USA. 109, 20800-20807.
Nakagawa, H., M. Toda, H. Atsumi, M. Hagihara, M. Hayashi-Nishino, C. Dohno, and K. Nakatani. (2012) Assembly of a small DNA rectangular parallelepiped block into higher order nanostructures. Chem. Lett. 41, 1550-1552.
Iino, R., K. Hayama, H. Amezawa, S. Sakakihara, S. H. Kim, Y. Matsumoto, K. Nishino, A. Yamaguchi, and H. Noji. (2012) A single-cell drug efflux assay in bacteria by using a directly accessible femtoliter droplet array. Lab Chip 12, 3923-3929.
Hayashi-Nishino, M., A. Fukushima, and K. Nishino. (2012) Impact of Hfq on the intrinsic drug resistance of Salmonella enterica serovar Typhimurium. Front. Microbiol. 3, 205.
Nikaido, E., E. Giraud, S. Baucheron, S. Yamasaki, A. Wiedemann, K. Okamoto, T. Takagi, A. Yamaguchi, A. Cloeckaert, and K. Nishino. (2012) Effects of indole on drug resistance and virulence of Salmonella enterica serovar Typhimurium revealed by genome-wide analyses. Gut Pathog. 4, 5.
Shan, Y., Q. Pan, J. Liu, F. Fuang, F. Sun, K. Nishino, and A. Yan. (2012) Covalently linking the Escherichia coli global anaerobic regulator FNR in tandem allows it to function as an oxygen stable dimer. Biochem. Biophys. Res. Commun. 419, 43-48.
Matsumoto, Y., K. Kaihatsu, K. Nishino, M. Ogawa, N. Kato, and A. Yamaguchi. (2012) Antibacterial and antifungal activities of new acylated derivatives of epigallocatechin gallate. Front. Microbiol. 3, 53.
Iino, R., K. Nishino, H. Noji, A. Yamaguchi, and Y. Matsumoto. (2012) A microfluidic device for simple and rapid evaluation of multidrug efflux pump inhibitors. Front. Microbiol. 3, 40. (Review)
西野邦彦. (2012) 多剤排出ポンプによる細菌機能制御 (Physiological role of bacterial multidrug efflux pumps). 薬学雑誌 (Yakugaku Zasshi) 132, 45-50.
その他著書等
西野—林美都子.（19名による共同執筆）
14章「電子顕微鏡を用いたオートファジー解析」担当
オートファジー 生命をささえる細胞の自己分解システム
水島昇・吉森保/編 化学同人
西野—林美都子. E. 見る！-電子顕微鏡の基礎と応用-「電子線トモグラフィーによる細胞小器官の3D解析」pp. 213-217 組織細胞化学2012 組織細胞化学技術プロトコール 組織細胞化学の挑戦 -臨床応用研究への飛躍-
日本組織細胞化学会/編
（2012年7月10日発行）
西野邦彦.「薬学用語辞典」微生物学分野担当
日本薬学会/編 東京化学同人
（2012年3月30日発行）
2011
Nakashima, R., K. Sakurai, S. Yamasaki, K. Nishino, and A. Yamaguchi. (2011) Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket. Nature 480, 565-569.
西野邦彦. (2011) 細菌の薬剤排出タンパクと生存戦略. 感染・炎症・免疫 (Infection Inflammation Immunity) 41, 335-338.
西野邦彦. (2011) 抗菌薬排出トランスポーター. 検査と技術 (Modern Medical Laboratory), 39, 677-684.
Zhang, Y., M. Xiao, T. Horiyama, Y. Zhang, X. Li, K. Nishino, and A. Yan. (2011) The multidrug efflux pump MdtEF protects against nitrosative damage during the anaerobic respiration in Escherichia coli. J. Biol. Chem. 286, 26576-26584.
Yamasaki, S., S. Nagasawa, M. Hayashi-Nishino, A. Yamaguchi, and K. Nishino. (2011) AcrA dependency of the AcrD efflux pump in Salmonella enterica serovar Typhimurium. J. Antibiot. 64, 433-437.
西野邦彦. (2011) 薬剤排出ポンプによる細菌多剤耐性化･病原性発現制御 (Bacterial multidrug resistance and virulence mediated by multidrug efflux pumps). 化学療法の領域 (Antibiotics & Chemotherapy) 27, 1495-1503.
Matsumoto, Y., K. Hayama, S. Sakakihara, K. Nishino, H. Noji, R. Iino, and A. Yamaguchi. (2011) Evaluation of multidrug efflux pump inhibitors by a new method using microfluidic channels. PLoS One 6, e18547.
Nikaido, E., I. Shirosaka, A. Yamaguchi, and K. Nishino. (2011) Regulation of AcrAB multidrug efflux pump in Salmonella enterica serovar Typhimurium in response to indole and paraquat. Microbiology 157, 648-655.
Nishino, K., S. Yamasaki, M. Hayashi-Nishino, and A. Yamaguchi. (2011) Effect of overexpression of small noncoding DsrA RNA on multidrug efflux in Escherichia coli. J. Antimicrob. Chemother. 66, 291-296.
Horiyama, T., E. Nikaido, A. Yamaguchi, and K. Nishino. (2011) Roles of Salmonella multidrug efflux pumps in tigecycline resistance. J. Antimicrob. Chemother. 66, 105-110.
西野邦彦、山﨑聖司、西野—林美都子、山口明人. (2011) Small RNA による多剤耐性制御 (Small RNA-mediated bacterial multidrug resistance). 日本化学療法学会雑誌 (Japanese Journal of Chemotherapy) 59, 1-7.
その他著書等
西野邦彦. 8章 感染症の治療ー抗微生物薬「はじめの一歩のイラスト感染症・微生物学」大阪大学微生物病研究会・本田武司/編 羊土社
（2011年7月20日発行）
2010
西野邦彦. (2010) エピジェネティクスと細菌の多剤耐性制御 (Epigenetics and regulation of bacterial multidrug resistance). 表面 (Reviews and Topics on Surface Science & Technology Avant-grade) 48, 365-374.
Hirakawa, H., M. Hayashi-Nishino, A. Yamaguchi, and K. Nishino. (2010) Indole enhances acid resistance in Escherichia coli. Microb. Pathog. 49, 90-94.
Horiyama, T., A. Yamaguchi, and K. Nishino. (2010) TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium. J. Antimicrob. Chemother. 65, 1372-1376.
Nishino, K., S. Yamasaki, M. Hayashi-Nishino, and A. Yamaguchi. (2010) Effect of NlpE overproduction on multidrug resistance in Escherichia coli. Antimicrob. Agents Chemother. 54, 2239-2243.
Yamada, J., S. Yamasaki, H. Hirakawa, M. Hayashi-Nishino, A. Yamaguchi and K.Nishino. (2010) Impact of RNA chaperone Hfq on multidrug resistance in Escherichia coli. J. Antimicrob. Chemother. 65, 853-858.
Hayashi-Nishino, M., N. Fujita, T. Noda, A. Yamaguchi, T. Yoshimori, and A. Yamamoto. (2010) Electron tomography reveals the endoplasmic reticulum as a membrane source for autophagosome formation. Autophagy 6, 301-303.
2009
Hayashi-Nishino, M., N. Fujita, T. Noda, A. Yamaguchi, T. Yoshimori, and A. Yamamoto. (2009) A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nature Cell Biol. 11, 1433-1437.
西野邦彦. (2009) 薬剤輸送と病原性発現に関与する膜蛋白質機能の解明 (Roles of drug efflux pumps in bacterial multidrug resistance and virulence). 表面 (Reviews and Topics on Surface Science & Technology Avant-grade) 47, 235-245.
Nishino, K., M. Hayashi-Nishino, and A. Yamaguchi. (2009) H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing acrEF multidrug efflux genes. Antimicrob. Agents Chemother. 53, 3541-3543.
Nishino, K., Y. Senda, M. Hayashi-Nishino, and A. Yamaguchi. (2009) Role of the AraC/XylS family regulator YdeO in multidrug resistance of Escherichia coli. J. Antibiot. 62, 251-257.
Nishino, K., E. Nikaido, and A. Yamaguchi. (2009) Regulation and physiological function of multidrug efflux pumps in Escherichia coli and Salmonella. BBA - Proteins & Proteomics 1794, 834-843.
Nikaido, E., I. Shirosaka, A. Yamaguchi, and K. Nishino. (2009) Regulation of the AcrAB multidrug efflux pump in Salmonella enterica serovar Typhimurium. Recent Advances in Clinical Pharmacology 30, 77-84.
2008
Nikaido, E., A. Yamaguchi, and K. Nishino. (2008) AcrAB multidrug efflux pump regulation in Salmonella enterica serovar Typhimurium by RamA in response to environmental signals. J. Biol. Chem. 283, 24245-24253.
Nishino, K., and A. Yamaguchi. (2008) Virulence and drug resistance roles of multidrug efflux pumps in Escherichia coli and Salmonella. Bioscience Microflora 27, 75-85.
西野邦彦、山口明人. (2008) グラム陰性菌における薬剤排出システムの役割 (Physiological functions of drug efflux systems in Gram-negative bacteria: Their roles in bacterial drug resistance and virulence). 日本化学療法学会雑誌 (Japanese Journal of Chemotherapy) 56, 443-452.
Hirakawa, H., A. Takumi-Kobayashi, U. Theisen, T. Hirata, K. Nishino, and A. Yamaguchi. (2008) AcrS/EnvR represses the expression of the acrAB multidrug efflux genes in Escherichia coli. J. Bacteriol. 190, 6276-6279.
Nishino, K., and A. Yamaguchi. (2008) Role of xenobiotic transporters in bacterial drug resistance and virulence. IUBMB Life 60, 569-574.
Nishino, K., Y. Senda, and A. Yamaguchi. (2008) CRP regulator modulates multidrug resistance of Escherichia coli by repressing expression of the mdtEF multidrug efflux genes. J. Antibiot. 61, 120-127.
西野邦彦. (2008) 病原性発現と薬剤耐性化における排出ポンプの役割 (Roles of efflux pumps in bacterial virulence and multidrug resistance). 化学療法の領域 (Antibiotics & Chemotherapy) 24, 354-362.
西野邦彦. (2008) 細菌多剤耐性化と病原性発現における薬剤排出ポンプの役割に関する研究－多剤耐性化と病原性を軽減させる新薬ターゲットの解析－(Roles of drug efflux pumps in bacterial multidrug resistance and virulence – Analysis to identify novel drug targets and counteract multidrug resistance and virulence –). The Japanese Journal of Antibiotics 61, 105-113.
Nishino, K., Y. Senda, and A. Yamaguchi. (2008) The AraC-family regulator GadX enhances multidrug resistance of Escherichia coli by activating expression of the mdtEF multidrug efflux genes. J. Infect. Chemother. 14, 23-29.
Higashi, K., H. Ishigure, R. Demizu, T. Uemura, K. Nishino, A. Yamaguchi, K. Kashiwagi, and K. Igarashi. (2008) Identification of a spermidine excretion protein complex (MdtJI) in Escherichia coli. J. Bacteriol. 190, 872-878.
2007
Nishino, K., E. Nikaido, and A. Yamaguchi. (2007) Regulation of multidrug efflux systems involved in multidrug and metal resistance of Salmonella enterica.
J. Bacteriol. 189, 9066-9075.
西野邦彦.（2007）薬剤耐性と病原性発現における異物排出トランスポーターの役割 (Roles of xenobiotic transporters in bacterial drug resistance and virulence). 日本臨牀 新感染症学 上巻 –新時代の基礎・臨床研究– 65 (2), 407-414.
2006
Nishino, K., L. Tammy, and E. A. Groisman. (2006) Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium.
Mol. Microbiol. 59, 126-141.
Nishino, K., F. F. Hsu, J. Turk, M. J. Cromie, M. M. Wösten, and E. A. Groisman. (2006) Identification of the lipopolysaccharide modifications controlled by the Salmonella PmrA/PmrB system mediating resistance to Fe(III) and Al(III).
Mol. Microbiol. 61, 645-654.
Kobayashi, A., H. Hirakawa, T. Hirata, K. Nishinio, and A. Yamaguchi. (2006) Growth phase-dependent expression of drug exporters in Escherichia coli and its contribution to the drug tolerance. J. Bacteriol. 188, 5693-5703.
Hirakawa, H., Y. Inazumi, Y. Senda, A. Kobayashi, T. Hirata, K. Nishino, and A. Yamaguchi. (2006) N-Acetyl-D-glucosamine induces the expression of a multidrug exporter gene, mdtEF, via catabolite activation in Escherichia coli. J. Bacteriol. 188, 5851-5858.
Yamada, S., N. Awano, K. Inubushi, E. Maeda, S. Nakamori, K. Nishino, A. Yamaguchi, and H. Takagi. (2006) Effect of drug transporter genes on cysteine export and overproduction in Escherichia coli. Appl. Environ. Microbiol. 72, 4735-4742.
2005
Nishino, K.（2005）*Bacterial multidrug exporters: Insights into acquisition of multidrug resistance. Science (online publication) (*Young Scientist Award 受賞論文. Science 307, 864. [2005])
Zwir, I., D. Shin, A. Kato, K. Nishino, T. Latifi, F. Solomon, J. M. Hare, H. Huang, and E. A. Groisman. (2005) Dissecting the PhoP regulatory network of Escherichia coli and Salmonella enterica. Proc. Natl. Acad. Sci. USA. 102, 2862-2867.
Nishino, K., T. Honda, and A. Yamaguchi. (2005) Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system. J. Bacteriol. 187, 1763-1772.
2004
Nishino, K., and A. Yamaguchi. (2004) Role of histone-like protein H-NS in multidrug resistance of Escherichia coli. J. Bacteriol. 186, 1423-1429.
Hirata, T., A. Saito, K. Nishino, N. Tamura, and A. Yamaguchi. (2004) Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936). Antimicrob. Agents Chemother. 48, 2179-2184.
2003
Nishino, K., J. Yamada, H. Hirakawa, T. Hirata, and A. Yamaguchi. (2003) Roles of TolC-dependent type multidrug transporters of Escherichia coli in resistance to ß-lactams. Antimicrob. Agents Chemother. 47, 3030-3033.
西野邦彦. (2003) *薬剤排出蛋白質遺伝子資源の解析に関する研究 (Whole genome approach of drug exporter genes and their regulatory networks). 日本細菌学雑誌 58, 581-594.（*日本細菌学会・黒屋奨学賞受賞論文）
Hirakawa, H., K. Nishino, J. Yamada, T. Hirata, and A. Yamagcuhi. (2003) ß-Lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli. J. Antimicrob. Chemother. 52, 576-582.
Kobayashi, N., K. Nishino, T. Hirata, and A. Yamaguchi. (2003) Membrane topology of ABC-type macrolide antibiotic exporter MacB in Escherichia coli. FEBS Lett. 546, 241-246.
Nishino, K., Y. Inazumi, and A. Yamaguchi. (2003) Global analysis of genes regulated by EvgA of the two-component regulatory system in Escherichia coli. J. Bacteriol. 185, 2667-2672.
Hirakawa, H., K. Nishino, T. Hirata, and A. Yamagcuhi. (2003) Comprehensive studies on the drug resistance mediated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli. J. Bacteriol. 185, 1851-1856.
2002
Nishino, K., and A. Yamaguchi. (2002) EvgA of the two-component signal transduction system modulates production of the YhiUV multidrug transporter in Escherichia coli. J. Bacteriol. 184, 2319-2323.
*Nagakubo, S., *K. Nishino, T. Hirata, and A. Yamaguchi. (2002) The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC. J. Bacteriol. 184, 4161-4167. (*Co-first author)
西野邦彦、山口明人. (2002) 細菌ゲノムに潜む薬剤耐性因子 (Postgenomic approach for bacterial drug resistance factors based on drug exporters and two-component signal transduction systems). 日本細菌学雑誌 57, 453-464.
2001
Nishino, K., and A. Yamaguchi. (2001) Analysis of a complete library of putative drug transporter genes in Escherichia coli. J. Bacteriol. 183, 5803-5812.
*Kobayashi, N., *K. Nishino, and A. Yamaguchi. (2001) Novel macrolide-specific ABC-type efflux transporter in Escherichia coli. J. Bacteriol. 183, 5639-5644. (*Co-first author)
Nishino, K., and A. Yamaguchi. (2001) Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters. J. Bacteriol. 183, 1455-1458.
2000
山口明人、西野邦彦. (2000) 薬剤排出タンパク質とゲノム創薬への応用 (Postgenomic approach for bacterial drug resistance based on xenobiotic exporters). バイオサイエンスとインダストリー 58, 313-318.