Multidrug efflux pumps play a major role in the multidrug resistance by extruding antibiotics or biocides out of the cell. Recent discoveries support the notion that at least some multidrug efflux pumps have specific physiological substrates because these pumps have been shown to have roles in bacterial virulence. We are interested in understanding physiological functions of multidrug efflux pumps. This knowledge should promote the development of novel inhibitors or strategies that could counteract the contribution of efflux pumps to drug resistance and virulence.

Kunihiko Nishino, Ph.D.


Institute of Scientific and Industrial Research

Osaka University

8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

What we do

大阪大学 産業科学研究所


西野研究室(Nishino Lab)

大阪大学 大学院薬学研究科・薬学部