Homeへ
小野　尭生 （おの　たかお）

助教
博士(工学)
E-mail: t-onosanken.osaka-u.ac.jp
Tel: 06-6879-8412
研究・教育歴
2007.3東京大学工学部マテリアル工学科卒
2009.3東京大学大学院工学系研究科バイオエンジニアリング専攻修
士課程修了
2012.3東京大学大学院工学系研究科バイオエンジニアリング専攻博
士課程修了
2012.3博士(工学)学位取得(東京大学)
2012.4日本学術振興会　特別研究員PD（東京大学大学院工学系研究科
バイオエンジニアリング専攻）
2013.4東京大学大学院工学系研究科バイオエンジニアリング専攻
学術支援専門職員
2013.5東京大学大学院工学系研究科応用化学専攻　特任研究員
2015.1大阪大学産業科学研究所　助教(現在)
2019.10科学技術振興機構　さきがけ「量子生体」研究者(兼任)

受賞
2011.1“Award for Encouragement of Research of Materials Science”
20th Academic Symposium of MRS-Japan 2010
2012.1“Award for Encouragement of Research of Materials Science”
21st Academic Symposium of MRS-Japan 2011
2012.9応用物理学会講演奨励賞、第59回応用物理学関係連合講演
会
2018.2産学連携賞、nano tech 2018 第17回 国際ナノテクノロジー
総合展・技術会議
2020.11大阪大学賞　若手教員部門、大阪大学
2023.11横河電機賞　企業参画型ピッチコンテスト、第61回日本生物物理学会年会

報道
2015.12日刊工業新聞 33面
2018.7JST News p.12-13
2018.8nanotechJapan Bulletin vol. 11, No. 4
2020.6.26電波新聞 12面 新聞記事は こちら(阪大産研HP)

論文
  • Takao Ono, Miho Kannaka, Yasushi Kanai, Naruto Miyakawa, Ayumi Shinagawa, Shin-ichi Nakakita, Yohei Watanabe, Shota Ushiba, Shinsuke Tani, Yasuo Suzuki, Masahiko Kimura, Daichi Chiba and Kazuhiko Matsumoto, "Elastomer-coated graphene biosensor and its response to enzymatic reactions" Japanese Journal of Applied Physics 62(6), 067002 (2023).
  • Tohru Sugahara, Yukiko Hirose, Jun-ichi Nakamura, Takao Ono, Takafumi Uemura, Makoto Karakawa, Toshio Itoh, Woosuck Shin, Yang Yang, Nobuyuki Harada, and Katsuaki Suganuma, "Carrier-Type Switching with Gas Detection Using a Low-Impedance Hybrid Sensor of 2D Graphene Layer and MoOx Nanorod 3D Network" ACS Applied Engineering Materials 1(4), 1086 (2023).
  • Yasuha Arai, Itaru Yamanaka, Toru Okamoto, Ayana Isobe, Naomi Nakai, Naoko Kamimura, Tatsuya Suzuki, Tomo Daidoji, Takao Ono, Takaaki Nakaya, Kazuhiko Matsumoto, Daisuke Okuzaki, and Yohei Watanabe, "Stimulation of interferon-β responses by aberrant SARS-CoV-2 small viral RNAs acting as retinoic acid-inducible gene-I agonists" iScience 26(1), 105742 (2023).
  • Ayana Isobe, Yasuha Arai, Daisuke Kuroda, Nobuaki Okumura, Takao Ono, Shota Ushiba, Shin-ichi Nakakita, Tomo Daidoji, Yasuo Suzuki, Takaaki Nakaya, Kazuhiko Matsumoto, and Yohei Watanabe, "ACE2 N-glycosylation modulates interactions with SARS-CoV-2 spike protein in a site-specific manner" Commun. Biol. 5, 1188 (2022).
  • Shota Ushiba, Tomomi Nakano, Naruto Miyakawa, Ayumi Shinagawa, Takao Ono, Yasushi Kanai, Shinsuke Tani, Masahiko Kimura, and Kazuhiko Matsumoto, “Robust graphene field-effect transistor biosensors via hydrophobization of SiO2 substrates” Applied Physics Express 15 115002 (2022).
  • Yuka Oka, Shota Ushiba, Naruto Miyakawa, Madoka Nishio, Takao Ono, Yasushi Kanai, Yohei Watanabe, Shinsuke Tani, Masahiko Kimura, and Kazuhiko Matsumoto, “Ionic strength-sensitive and pH-insensitive interactions between C-reactive protein (CRP) and an anti-CRP antibody” Biophysics and Physicobiology 19 e190003_1-9 (2022).
  • Naruto Miyakawa, Ayumi Shinagawa, Yasuko Kajiwara, Shota Ushiba, Takao Ono, Yasushi Kanai, Shinsuke Tani, Masahiko Kimura, and Kazuhiko Matsumoto, "Drift Suppression of Solution-Gated Graphene Field-Effect Transistors by Cation Doping for Sensing Platforms" Sensors 21(22) 7455 (2021).
  • Emad Mohamed Elgendy, Yasuha Arai, Norihito Kawashita, Ayana Isobe, Tomo Daidoji, Madiha Salah Ibrahim, Takao Ono, Tatsuya Takagi, Takaaki Nakaya, Kazuhiko Matsumoto, and Yohei Watanabe, "Double mutations in the H9N2 avian influenza virus PB2 gene act cooperatively to increase viral host adaptation and replication for human infections", J. gen. virol. 102(6), 001612 (2021).
  • Shota Ushiba, Naruto Miyakawa, Naoya Ito, Ayumi Shinagawa, Tomomi Nakano, Tsuyoshi Okino, Hiroki K. Sato, Yuka Oka, Madoka Nishio, Takao Ono, Yasushi Kanai, Seiji Innami, Shinsuke Tani, Masahiko Kimuara, and Kazuhiko Matstumoto, "Deep-learning-based semantic image segmentation of graphene field-effect transistors", Appl. Phys. Express 14, 036504 (2021).
  • Yasuha Arai, Norihito Kawashita, Emad Mohamed Elgendy, Madiha Salah Ibrahim, Tomo Daidoji, Takao Ono, Tatsuya Takagi, Takaaki Nakaya, Kazuhiko Matsumoto, and Yohei Watanabe, "PA mutations inherited during viral evolution act cooperatively to increase replication of contemporary H5N1 influenza virus with an expanded host range", J. Virol. 95(1), e01582-20 (2021).
  • Yasuha Arai, Emad Mohamed Elgendy, Tomo Daidoji, Madiha Salah Ibrahim, Takao Ono, Nongluk Sriwilaijaroen, Yasuo Suzuki, Takaaki Nakaya, Kazuhiko Matsumoto, and Yohei Watanabe, "H9N2 influenza virus infections in human cells require a balance between NA sialidase activity and HA receptor affinity", J. Virol 94(18), e01210-20 (2020).
  • Shoichiro Fukushima, Masaaki Shimatani, Satoshi Okuda, Shinpei Ogawa, Yasushi Kanai, Takao Ono, Koichi Inoue, and Kazuhiko Matsumoto, "Photogating for small high-responsivity graphene middle-wavelength infrared photodetectors", Opt. Eng., 59(3), 037101 (2020).
  • Masaaki Shimatani, Shoichiro Fukushima, Satoshi Okuda, Shinpei Ogawa, Yasushi Kanai, Takao Ono, Koichi Inoue, and Kazuhiko Matsumoto, "Room temperature long-wavelength infrared graphene photodetectors using photogating via the pyroelectric effect", Proceedings of Infrared Technology and Applications XLVI, SPIE Defense + Commercial Sensing 1140717 (2020).
  • Shoichiro Fukushima, Masaaki Shimatani, Satoshi Okuda, Shinpei Ogawa, Yasushi Kanai, Takao Ono, Koichi Inoue, and Kazuhiko Matsumoto, "Middle wavelength infrared graphene photodetectors with low dark-current and high responsivity", Proceedings of Infrared Technology and Applications XLVI, SPIE Defense + Commercial Sensing 1140718 (2020).
  • Shota Ushiba, Tsuyoshi Okino, Naruto Miyakawa, Takao Ono, Ayumi Shinagawa, Yasushi Kanai, Kouichi Inoue, Kohei Takahashi, Masahiko Kimura and Kazuhiko Matsumoto, "State-space modeling for dynamic response of graphene FET biosensors", Jpn. J. Appl. Phys. 59, SGGH04 (2020).
  • Yasushi Kanai, Yuki Ohmuro-Matsuyama, Masami Tanioku, Shota Ushiba, Takao Ono, Koichi Inoue, Tetsuya Kitaguchi, Masahiko Kimura, Hiroshi Ueda and Kazuhiko Matsumoto, "Graphene Field Effect Transistor-Based Immunosensor for Ultrasensitive Noncompetitive Detection of Small Antigens", ACS Sensors 5(1), 24-28 (2020).
  • Chuantong Chen, Zheng Zhang, Dongjin Kim, Bowen Zhang, Masami Tanioku, Takao Ono, Kazuhiko Matsumoto, and Katsuaki Suganuma, "Interfacial oxidation protection and thermal-stable sinter Ag joining on bare Cu substrate by single-layer graphene coating", Appl. Surf. Sci. 497, 143797 (2019).
  • Yasuha Arai, Norihito Kawashita, Madiha Salah Ibrahim, Emad Mohamed Elgendy, Tomo Daidoji, Takao Ono, Tatsuya Takagi, Takaaki Nakaya, Kazuhiko Matsumoto, "PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammals", PLOS Pathogens 15, e1007919 (2019).
  • Toshio Kawahara, Hiroaki Hiramatsu, Yuhsuke Ohmi, Nongluk Sriwilaijaroen, Yasuo Suzuki, Shin-ichi Nakakita, Yohei Watanabe, Yasuhide Ohno, Kenzo Maehashi, Takao Ono, Yasushi Kanai and Kazuhiko Matsumoto, "Effective binding of sugar chains to influenza virus on the surface by bovine serum albumin localization", Jpn. J. Appl. Phys. 58, SIID03 (1)-(5) (2019).
  • Takao Ono, Yasushi Kanai, Koichi Inoue, Yohei Watanabe, Shin-ichi Nakakita, Toshio Kawahara, Yasuo Suzuki and Kazuhiko Matsumoto, "Electrical biosensing at physiological ionic strength using graphene field-effect transistor in femtoliter microdroplet", Nano Lett. 19, 4004-4009 (2019).
  • Shinpei Ogawa, Masaaki Shimatani, Shoichiro Fukushima, Satoshi Okuda, Yasushi Kanai, Takao Ono, Kazuhiko Matsumoto, "Broadband photoresponse of graphene photodetector from visible to long-wavelength infrared wavelengths", Optical Engineering 58 (5), 057106, (1)-(6) (2019).
  • Shoichiro Fukushima, Masaaki Shimatani, Satoshi Okuda, Shinpei Ogawa, Yasushi Kanai, Takao Ono, Koichi Inoue, and Kazuhiko Matsumoto, "Low dark current and high-responsivity graphene mid-infrared photodetectors using amplification of injected photo-carriers by photo-gating", Opt. Lett. 44, 2598-2601 (2019).
  • Masaaki Shimatani, Shinpei Ogawa, Shoichiro Fukushima, Satoshi Okuda, Yasushi Kanai, Takao Ono and Kazuhiko Matsumoto, "Enhanced photogating via pyroelectric effect induced by insulator layer for high-responsivity long-wavelength infrared graphene-based photodetectors operating at room temperature", Appl. Phys. Express 12, 025001 (2019).
  • Shoichiro Fukushima, Masaaki Shimatani, Satoshi Okuda, Shinpei Ogawa, Yasushi Kanai, Takao Ono, and Kazuhiko Matsumoto, "High responsivity middle-wavelength infrared graphene photodetectors using photo-gating”,Appl. Phys. Lett 113, 061102 (2018).
  • Yohei Watanabe, Yasuha Arai, Norihito Kawashita, Madiha S. Ibrahim, Emad M. Elgendy, Tomo Daidoji, Junichi Kajikawa, Hiroaki Hiramatsu, Nongluk Sriwilaijaroen, Takao Ono, Tatsuya Takagi, Kazuo Takahashi, Tatsuo Shioda, Kazuhiko Matsumoto, Yasuo Suzuki, Takaaki Nakaya, “Characterization of H5N1 Influenza Virus Quasispecies with Adaptive Hemagglutinin Mutations from Single-Virus Infections of Human Airway Cells”, J. Virol. 92, e02004-17 (2018).
  • Nongluk Sriwilaijaroen, Shin-ichi Nakakita, Sachiko Kondo, Hirokazu Yagi, Koichi Kato, Takeomi Murata, Hiroaki Hiramatsu, Toshio Kawahara, Yohei Watanabe, Yasushi Kanai, Takao Ono, Jun Hirabayashi, Kazuhiko Matsumoto and Yasuo Suzuki, FEBS J. 285, 1611-1634 (2018).
  • Takuya Kawata, Takao Ono, Yasushi Kanai, Yasuhide Ohno, Kenzo Maehashi, Koichi Inoue and Kazuhiko Matsumoto, “Improved sensitivity of a graphene FET biosensor using porphyrin linkers”, Jpn. J. Appl. Phys. 57, 065103 (2018).
  • Shota Ushiba, Takao Ono, Yasushi Kanai, Koichi Inoue, Masahiko Kimura, and Kazuhiko Matsumoto, “Graphene as an Imaging Platform of Charged Molecules”, ACS Omega 3(3), 3137-3142 (2018).
  • Satoshi Okuda, Takao Ono, Yasushi Kanai, Takashi Ikuta, Masaaki Shimatani, Shinpei Ogawa, Kenzo Maehashi, Koichi Inoue, and Kazuhiko Matsumoto, “Graphene Surface Acoustic Wave Sensor for Simultaneous Detection of Charge and Mass”, ACS Sens. 3(1), 200-204 (2018).
  • Takao Ono, Takanori Ichiki and Hiroyuki Noji, “Digital enzyme assay using attoliter droplet array”, Analyst 143, 4923-4929 (2018).
  • Yasushi Kanai, Mohamed Almokhtar, Takao Ono, Yasuhide Ohno, Kenzo Maehashi, Kouichi Inoue and Kazuhiko Matsumoto, “Zero-bias conductance anomaly in graphene dots”,Jpn. J. Appl. Phys. 56, 06GE07 (2017).
  • Yasushi Kanai, Yusuke Ishibashi, Takao Ono, Koichi Inoue, Yasuhide Ohno, Kenzo Maehashi and Kazuhiko Matsumoto, “Dynamical thermodiffusion model of graphene synthesis on polymer films by laser irradiation and application to strain sensors,”Jpn. J. Appl. Phys. 56, 075102 (2017).
  • Takao Ono, Takeshi Oe, Yasushi Kanai, Takashi Ikuta, Yasuhide Ohno, Kenzo Maehashi, Koichi Inoue, Yohei Watanabe, Shin-ichi Nakakita, Yasuo Suzuki, Toshio Kawahara and Kazuhiko Matsumoto, “Glycan-functionalized graphene-FETs toward selective detection of human-infectious avian influenza virus”, Jpn. J. Appl. Phys. 56(3), 030302 (2017).
  • Masaaki Shimatani, Shinpei Ogawa, Daisuke Fujisawa, Satoshi Okuda, Yasushi Kanai, Takao Ono, and Kazuhiko Matsumoto, “Photocurrent enhancement of graphene phototransistors using p?n junction formed by conventional photolithography process”,Jpn. J. Appl. Phys. 55, 110307 (2016).
  • Satoshi Okuda, Takashi Ikuta, Yasushi Kanai, Takao Ono, Shinpei Ogawa, Daisuke Fujisawa, Masaaki Shimatani, Koichi Inoue, Kenzo Maehashi and Kazuhiko Matsumoto, “Acoustic carrier transportation induced by surface acoustic waves in graphene in solution”,Appl. Phys. Express 9, 045104 (2016).
  • Masaaki Shimatani, Shinpei Ogawa, Daisuke Fujisawa, Satoshi Okuda, Yasushi Kanai, Takao Ono and Kazuhiko Matsumoto, “Giant Dirac point shift of graphene phototransistors by doped silicon substrate current”, AIP Advances 6, 035113 (2016).
  • Takao Ono, Ryo Iizuka, Takanori Akagi, Takashi Funatsu and Takanori Ichiki, “Optical Observation of Deep Bulk Damage in Amorphous Perfluorocarbon Films Produced by UV Photons Emitted from Low-Pressure Argon Plasma”, J. Photopolym. Sci. Technol. 27(3), 393-398 (2014).
  • Takao Ono, Ryo Iizuka, Takanori Akagi, Takashi Funatsu and Takanori Ichiki, “Damage-free Fabrication of Perfluoropolymer Microaperture Array Device for Single-molecule Imaging”, Trans. Mater. Res. Soc. Jpn. 36(4), 553-556 (2011).
  • Takao Ono, Takanori Akagi and Takanori Ichiki, “Hydrophilization of Amorphous Perfluoropolymer using Low-pressure Argon Plasma”, J. Photopolym. Sci. Technol. 22(5), 683-689 (2009).
  • Takao Ono, Takanori Akagi and Takanori Ichiki, "Anisotropic etching of amorphous perfluoropolymer films in oxygen-based inductively coupled plasmas", J. Appl. Phys. 105, 013314 (2009).
  • Yoshiteru Hamada, Takao Ono, Takanori Akagi, Kazuhiko Ishihara, and Takanori Ichiki, “Photochemical oxidation of poly(dimethylsiloxane) surface and subsequent coating with biomimetic phosphorylcholine polymer,” J. Photopolym. Sci. Technol. 20, 245-249 (2007).

    • 総説
  • Takao Ono and Hiroyuki Noji, “Digital Bioassay with Femtoliter Reactor Array”Intelligent Nanosystems for Energy, Information and Biological Technologies, 107-116, Springer Japan, Tokyo (2016).
  • 小野尭生、金井康、大野恭秀、前橋兼三、井上恒一、松本和彦　「グラフェンを用いたバイオセンシング―DNA検出からインフルエンザ診断まで―」, MATERIAL STAGE 16, 65-70 (2016).
  • Takao Ono, Yasushi Kanai, Yasuhide Ohno, Kenzo Maehashi, Koichi Inoue, Kazuhiko Matsumoto “Lab-on-a-Graphene: Functionalized Graphene Transistors and Their Application for Biosensing,” Carbon-related Materials in Recognition of Nobel Lectures by Prof. Akira Suzuki in ICCE, 79-90, Springer International Publishing, New York (2017).
  • 小野 尭生、金井 康、奥田 聡志、大野 恭秀、前橋 兼三、井上 恒一、松本 和彦『グラフェンを基盤としたバイオセンシング -Lab on a graphene-』 電子情報通信学会論文誌C, J100-C, No. 11, 528-536 (2017).