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2021

(216) NMR determination of the 2:1 binding motif structure involving cytosine flipping out for the recognition of the CGG/CGG triad DNA, Yamada, T.; Furuita, K.; Sakurabayashi, S.; Nomura, M.; Kojima, C.; and Nakatani, K. submitted.

(215) Premature translation termination mediated non-ER stress induced ATF6 activation by a ligand-dependent ribosomal frameshifting circuit, Hsu, H. T.; Murata, A.; Dohno, C.; Nakatani, K.; Chang, K. Nucleic Acids Res. 2022,50, 5369-5383. doi.org/10.1093/nar/gkac257.

(214) CAG repeat-binding small molecule improves motor coordination impairment in a mouse model of Dentatorubral−pallidoluysian atrophy, Hasuike, Y.; Tanaka, H.; Gall-Duncan, T.; Mehkary, M.; Nakatani, K.; Pearson, C. E.; Tsuji, S.; Mochizuki, H.; Nakamori, M. Neurobiol. Dis. 2022, 163, 105604. DOI: 10.1016/j.nbd.2021.105604.

(213) Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model, Ni, L., Yamada, Y.; Murata, A.; Nakatani, K. Chem. Commun. 2022, 58, 3629-3632.

(212) 2-Amino-1,8-naphthyridine dimer (ANP77), a high affinity binder to the internal loops of C/CC and T/CC sites in double-stranded DNA, Das, B.; Nagano, K.; Kawai, G.; Murata, A.; Nakatani, K. J. Org. Chem. 2022, 87, 340-350. doi.org/10.1021/acs.joc.1c02383.

(211) HT-SELEX based identification of binding pre-miRNA hairpin-motif for small molecule, Mukherjee, S.; Murata, A.; Ishida, R.; Sugai, A.; Dohno, C.; Hamada, M.; Krishna, S.; Nakatani, K. Mol. Ther. Nucleic Acids 2022, 27, 165-174. doi.org/10.1016/j.omtn.2021.11.021.

(210) Possibilities and Challenges of Small Molecule Organic Compounds for the Treatment of Repeat Diseases, Nakatani, K. Proc. Jpn. Acad. B: Phys. Biol. Sci. 2022, 98, 30-48. doi.org/10.2183/pjab.98.003.

(209) FAN1 nuclease pauses on disease-associated slipped-DNA repeats: Mechanism against repeat expansions, Deshmukh, A. L.; Caron, M.-C.; Mohiuddin, M.; Lanni, S.; Panigrahi, G. B.; Khan, M.; Engchuan, W.; Shum, N.; Faruqui, A.; Wang, P.; Yuen, R. K. C.; Nakamori, M.; Nakatani, K.; Masson, J.-Y.; Pearson, C. E. Cell Rep. 2021, 37, 110078. doi.org/10.1016/j.celrep.2021.110078

(208) Short Tandem Repeat Contractions during in vitro DNA Synthesis by Repeat-Binding Molecules, Hagihara, M.; Dohno, C.; Saito, K.; Sugimoto, K.; Hishinuma, Y.; Sohma, Y.; Shibata, T.; Nakatani, K. Chem. Lett. 2021,50, 1848-1851. doi:10.1246/cl.210415.

(207) Cyclic mismatch binding ligands interact with disease-associated CGG trinucleotide repeats in RNA and suppress their translation, Konieczny, P.; Mukherjee, S.; Stepniak-Konieczna, E.; Taylor, K.; Niewiadomska, D.; Piasecka, A.; Walczak, A.; Baud, A.; Dohno, C.; Nakatani, K.; Sobczak, K. Nucleic Acids Res. 2021,49, 9479-9495. doi.org/10.1093/nar/gkab669.

(206) A small-molecule fluorescence probe ANP77 for sensing RNA internal loop of C, U, and A/CC motifs and their binding molecules, Das, B.; Murata, A.; Nakatani, K. Nucleic Acids Res. 2021,49, 8462-8470. doi.org/10.1093/nar/gkab650.

(205) Ab initio multi-level layered elongation method and its application to local interaction analysis between DNA bulge and ligand molecules, Hisama, K.; Orimoto, Y.; Pomogaeva, A.; Nakatani, K.; Aoki, Y. J. Chem. Phys. 2021,155, 044110. doi.org/10.1063/5.0050096.

(204) Rational Design of a Photoswitchable DNA Glue Enabling High Regulatory Function and Supramolecular Chirality Transfer, Simeth, N.; Kobayashi, S.; Kobauri, P.; Crespi, S.; Szymański, W.; Nakatani, K.; Dohno, C.; Feringa, B. Chem. Sci. 2021, 12, 9207-9220. DOI: 10.1039/D1SC02194J.

(203) Small molecule-induced trinucleotide repeat contractions during in vitro DNA synthesis, Dohno, C.; Hagihara, M.; Binti Mohd Zaifuddin, N.; Nihei, M.; Saito, K.; Nakatani, K. Chem. Commun. 2021, 57, 3235-3238. DOI: 10.1039/D1CC00349F.

(202) Speeding drug discovery targeting RNAs: an iterative "RNA selection-compounds screening cycle" for exploring RNA-small molecule pairs, Furuzono, T.; Murata, A.; Okuda, S.; Mizutani, K.; Adachi, T.; Nakatani, K. Bioorg. Med. Chem. 2021, 36, 16070-16076. doi.org/10.1016/j.bmc.2021.116070.

(201) Small molecule-induced dimerization of hairpin RNA interfered with the Dicer cleavage reaction, Murata, A.; Mori, Y.; Di, Y.; Sugai, A.; Das, B.; Takashima, Y.; Nakatani, K. Biochemistry 2021, 60, 245-249. doi.org/10.1021/acs.biochem.0c00920.

(200) Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model, Shibata, T.; Nagano, K.; Ueyama, M.; Ninomiya, K.; Hirose, T.; Nagai, Y.; Ishikawa, K.; Kawai, G.; Nakatani, K. Nat. Commun. 2021, 12, 236. https://doi.org/10.1038/s41467-020-20487-4.

2020

(199) Chemical Probing of Thymine in the TGG/CGG Triad to Explore the Deamination of 5-Methylcytosine in the CGG Repeat, Yagi, Y.; Yamada, T.; Nakatani, K. Biochemistry 2020, 59, 2679-2683. 10.1021/acs.biochem.0c00333.

(198) The dimeric form of 1,3‐diaminoisoquinoline derivative rescued the mis‐splicing of Atp2a1 and Clcn1 genes in myotonic dystrophy type 1 mouse model, Matsumoto, J.; Nakamori, M.; Okamoto, T.; Murata, A.; Dohno, C.; Nakatani, K. Chem. Eur. J. 2020, 26, 14305-14309. doi: 10.1002/chem.202001572.

(197) Assembly of ruthenium complexes on double strand DNA using mismatch binding ligand, Ni, L.; Yamada, T.; Nakatani, K. Chem. Commun. 2020, 56, 5227-5230. DOI: 10.1039/D0CC01863E.

(196) Recognition of expanded GGGGCC hexanucleotide repeat by synthetic ligand through interhelical binding, Lu, Y.; Dohno, C.; Nakatani, K. Biochem. Biophys. Res. Commun. 2020, 531, 56-61. doi: 10.1016/j.bbrc.2020.03.107.

(195) Slipped-CAG DNA binding small molecule induces trinucleotide repeat contractions in vivo, Nakamori, M.; Panigrahi, G. B.; Lanni, S.; Gall-Duncan, T.; Hayakawa, H.; Tanaka, H.; Luo, J.; Otabe, T.; Li, J.; Sakata, A.; Caron, M. C.; Joshi, N.; Prasolava, T.; Chiang, K.; Masson, J. Y.; Wold, M. S.; Wang, X.; Lee, M.; Huddleston, J.; Munson, K. M.; Davidson, S.; Layeghifard, M.; Edward, L. M.; Gallon, R.; Santibanez-Koref, M.; Murata, A.; Takahashi, M. P.; Eichler, E. E.; Shlien, A.; Nakatani, K.; Mochizuki, H.; Pearson, C. E. Nat. Genet. 2020, 52, 146-159. doi: 10.1038/s41588-019-0575-8.

(194) Novel Naphthyridine Tetramer that Recognizes Tandem G−G Mismatches by Formation of Interhelical Complex, Lu, Y.; Dohno, C.; Nakatani, K. Chem. Commun. 2020, 56, 754-757. 10.1039/C9CC08111A.

2019

(193) Structural insights into synthetic ligands targeting A−A pairs in disease-related CAG RNA repeats, Mukherjee, S.; Błaszczyk, L.; Rypniewski, W.; Falschlunger, C.; Micura, R.; Murata, A.; Dohno, C.; Nakatani, K.; Kiliszek, A. Nucl. Acids Res. 2019,47, 10906-10913. doi.org/10.1093/nar/gkz832.

(192) RT-Hpro-PCR: A MicroRNA Detection System Utilizing a Primerwith a DNA Tag. Takei, F.; Akiyama, M.; Murata, A.; Sugai, A.; Nakatani, K.; Yamashita, I. ChemBioChem 2019, in press. doi: 10.1002/cbic.201900382.

(191) Molecular glue for RNA: Regulating RNA structure and function through a synthetic RNA binding molecule. Dohno, C.; Nakatani, K. ChemBioChem 2019, 20, 2903-2910. doi: 10.1002/cbic.201900223.

(190) Modulating RNA secondary and tertiary structures by mismatch binding ligands. Murata, A.; Nakamori, M.; Nakatani, K. Methods 2019,167, 78-91. doi: 10.1016/j.ymeth.2019.05.006.

(189) Domain-based local pair natural orbital CCSD(T) calculations of six different S1 structures of oxygen evolving complex of photosystem II. Proposal of multi-intermediate models for the S1 state.. Miyagawa, K.; Kawakami, T.; Isobe, H.; Shoji, M.; Yamanaka, S.; Nakatani, K.; Okumura, M.; Nakajima, T.; Yamaguchi, K. Chem. Phys. Lett. 2019, 732, 136660. doi.org/10.1016/j.cplett.2019.136660.

(188) Inhibition of pre-miRNA-136 processing by Dicer with small molecule BzDANP suggested the formation of ternary complex of pre-miR-136-BzDANP-Dicer. Otabe T.; Nagano K.; Kawai G.; Murata A.; Nakatani K. Bioorg. Med. Chem. 2019, 27, 2140-2148. doi: 10.1016/j.bmc.2019.03.031.

2018

(187) A dimeric 2,9-diamino-1,10-phenanthroline derivative improves alternative splicing in myotonic dystrophy type 1 cell and mouse models. Li, J.; Nakamori, M.; Matsumoto, J.; Murata, A.; Dohno, C.; Kiliszek, A.; Taylor, K.; Sobczak, K.; Nakatani, K. Chem. Eur. J. 2018, 24, 18115-18122. 10.1002/chem.201804368.

(186) CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation. Yamada, T.; Miki, S.; Ni, L.; Nakatani, K. Chem. Commun. 2018, 54, 13072-13075. 10.1039/C8CC06757K.

(185) Small synthetic molecule-stabilized RNA pseudoknot as an activator for −1 ribosomal frameshifting, Matsumoto, S.; Caliskan, N.; Rodnina, M. V.; Murata, A.; Nakatani, K. Nucl. Acids Res. 2018, 46, 8079-8089. doi.org/10.1093/nar/gky689.

(184) Electrical Nucleotide Sensor Based on Synthetic Guanine‐Receptor-Modified Electrodes, Ohshiro, T.; Verma, R. K.; Yokota, K.; Tsutsui, M.; Mukherjee, S.; Kawai, T.; Nakatani, K.; Taniguchi, M. Chemistry Select. 2018, 3, 3819-3824, doi.org/10.1002/slct.201702341.

(183) Expanding chemical space of DNA-binding molecules with three base-binding units. Yagi, Y.; Aikawa, H.; Yamada, T.; Nakatani, K. Bioorg. Med. Chem. Lett. 2018, 28, 2894-2898, DOI: 10.1016/j.bmcl.2018.07.024.

(182) 1,3-Di(quinolin-2-yl)guanidine binds to GGCCCC hexanucleotide repeat DNA in C9ORF72. Shibata, T.; Murakami, E.; Nakatani, K. Bioorg. Med. Chem. Lett. 2018, 28, 2364-2368, DOI: 10.1016/j.bmcl.2018.06.032.

(181) Bicyclic and tricyclic C-C mismatch-binding ligands bind to CCG trinucleotide repeat DNAs, Shibata, T.; Nakatani, K. Chem. Commun. 2018, 54, 7074-7077, doi: 10.1039/c8cc02393j.

(180) Relative stability between the manganese hydroxide- and oxo-models for water oxidation by CCSD, DMRG CASCI, CASSCF, CASPT2 and CASDFT methods; Importance of static and dynamical electron correlation effects for OEC of PSII, Kawakami, T.; Miyagawa, K.; Isobe, H.; Shoji, M.; Yamanaka, S.; Katouda, M.; Nakajima, T.; Nakatani, K.; Okumura, M.; Yamaguchi, K. Chem. Phys. Lett. 2018, 705, 85-91, DOI: 10.1016/j.cplett.2018.05.046.

(179) Restoration of Ribozyme Tertiary Contact and Function by Using a Molecular Glue for RNA. Dohno, C.; Kimura, M.; Nakatani, K. Angew. Chem. Int. Ed. 2018, 57, 506-510, DOI: 10.1002/anie.201709041.

(178) PCR under Low Ionic Concentration Buffer Conditions, Takei, F.; Akiyama, M.; Nobusawa, K.; Sabani, Norhayati Binti; Han, H.; Nakatani, K.; Yamashita, I. Chemistry Select 2018, 3, 973-976, doi: 10.1002/slct.201702542.

2017

(177) Synthesis of naphthyridine dimers with conformational restriction and the binding to DNA and RNA, Nakatani, K.; Natsuhara, N.; Mori, Y.; Mukherjee, S.; Das, B.; and Murata, A. Chem. Asian J. 2017, 12, 3077-3087, doi: 10.1002/asia.201701293.

(176) Synthesis of Naphthyridine Carbamate Dimer (NCD) Derivatives Modified with an Alkane Thiol and the Binding Properties to G−G Mismatch DNA, Yamada, T.; Miki, S.; Ulhusna, A.; Michikawa, A.; Nakatani, K. Org. Lett. 2017, 19, 4163-4166, doi: 10.1021/acs.orglett.7b01632.

(175) Design and synthesis of cyclic mismatch binding ligands (CMBLs) with variable linkers by ring closing metathesis and their photophysical and DNA repeat binding properties, Mukherjee, S.; Dohno, C.; Nakatani, K. Chem. Eur. J. 2017, in press, DOI: 10.1002/chem.201702064.

(174) Synthetic ligand promotes gene expression by affecting GC sequence in promoter, Matsumoto, S.; Iida, K.; Murata, A.; Denawa M.; Hagiwara, M.; Nakatani, K. Bioorg. Med. Chem. Lett. 2017, 27, 3391-3394, DOI: 10.1016/j.bmcl.2017.06.006.

(173) Amphiphilic DNA tiles for controlled insertion and 2D assembly on fluid lipid membranes: the effect on mechanical properties, Dohno, C.; Makishi, S.; Nakatani, K.; Contera, S. Nanoscale. 2017, 9, 3051-3058. DOI: 10.1039/C6NR07084A.

(172) Fluorescence turn-on hairpin-probe PCR, Takei, F. and Nakatani, K. Chem. Commun. 2017, 53, 1393-1396. doi: 10.1039/C6CC08947J.

(171) A 2,7-diamino-1,4,8-triazanaphthalene derivative selectively binds to cytosine bulge DNA only at a weakly acidic pH, Aikawa, H.; Yano, A.; Nakatani, K. Org. Biomol. Chem. 2017, 15, 1313-1316. doi: 10.1039/C6OB02273A. selected as inside front cover.

2016

(170) A Ligand that Targets CUG Trinucleotide Repeats, Li. J.; Matsumoto, J.; Bai, L.-P.; Murata, A.; Dohno, A.; Nakatani, K. Chem. Eur. J. 2016, 22, 14881-14889. doi: 10.1002/chem.201602741. selected as cover picture.

(169) BzDANP, a small-molecule modulator of pre-miR-29a maturation by Dicer, Murata, A.; Otabe, T.; Zhang, J.; Nakatani, K. ACS Chem. Biol. 2016, 11, 2790-2796. doi: 10.1021/acschembio.6b00214.

(168) Development of 2, 7-Diamino-1, 8-Naphthyridine (DANP) Anchored Hairpin Primers for RT-PCR Detection of Chikungunya Virus Infection, Chen, H.; Parimelalagan, M.; Takei, F.; Hapuarachchi, H. C.; Evelyn Siew-Chuan Koay, E. S.-C.; Ng, L. C.; Ho, P. S.; Nakatani, K.; Chu, J. J. H. PLOS Negl. Trop. Dis. 2016, 10, e0004887. doi: 10.1371/journal.pntd.0004887.

(167) Cyclic mismatch binding ligand CMBL4 binds to the 5'-T-3'/5'-GG-3' site by inducing the flipping out of thymine base, Mukherjee, S.; Dohno, C.; Asano, K.; Nakatani, K. Nucl. Acids Res. 2016, 44, 7090-7099. doi: 10.1093/nar/gkw672.

(166) Synthesis and photo-physical properties of fluorescence molecular probe for turn-ON type detection of cytosine bulge DNA, Verma, R.; Takei, F.; Nakatani, K. Org. Lett. 2016, 18, 3170-3173. doi: 10.1021/acs.orglett.6b01378.

(165) Fluorescence probe for detecting CCG trinucleotide repeat DNA expansion and slip-out, Shibata, T.; Nakatani, K. ChemBioChem. 2016, 17, 1685-1688. doi; 10.1002/cbic.201600200.

(164) Synthesis of 1H-pyrrolo[3,2-h]quinoline-8-amine derivatives that target CTG trinucleotide repeats, Matsumoto, J.; Li, J.; Dohno, C.; Nakatani, K. Bioorg. Med. Chem. Lett. 2016, 26, 3761-3764. doi:10.1016/j.bmcl.2016.05.062.

(163) Naphthyridine-Benzoazaquinolone: Evaluation of tricyclic system for the binding to (CAG)n Repeat DNA and RNA, Li, J.; Sakata, A.; He, H.; Bai, L.-P.; Murata, A.; Dohno, C.; Nakatani, K. Chem. Asian. J. 2016, 11, 1971-1981. doi: 10.1002/asia.201600527.

2015

(162) Exploratory Study on the RNA-Binding Structural Motifs by Library Screening Targeting pre-miRNA-29a. Fukuzumi, T.; Murata, A.; Aikawa, H.; Harada, Y.: Nakatani, K. Chem. Eur. J. 2015, 21, 16859-16867. doi: 10.1002/chem.201502913. Very Important Paper.

(161) A hybridisation-dependent membrane-insertable amphiphilic DNA, Dohno, C.; Matsuzaki, K.; Yamaguchi, H.; Shibata, T.; Nakatani, K. Org. Biomol. Chem. 2015, 13, 10117-10121. doi: 10.1039/C5OB01761K.

(160) 2-Aminophenanthroline dimer stabilized the C-C mismatched duplex DNA, Li, J.; Matsumoto, J. Otabe, T.; Dohno, C.; Nakatani, K. Bioorg. Med. Chem. 2015, 23, 753-758. doi: 10.1016/j.bmc.2014.12.062.

2014

(159) Recognition of Chelerythrine to Human Telomeric DNA and RNA G-quadruplexes, Bai, L.-P.; Hagihara, M.; Nakatani, K.; Jiang, Z.-H. Sci. Rep. 2014, 4, 6767.

(158) Cytosine-bulge dependent fluorescence quenching for real-time hairpin primer PCR, Takei, F.; Chen, X.; Yu, G.; Shibata, T.; Dohno, C.; Nakatani, K. Chem. Commun. 2014, 50, 15195-15198.

(157) Synthesis of 8-substituted adenine and adenosine libraries and the binding to pre-miR-29a, Fukuzumi, T.; Aikawa, H.; Harada, Y.; Sugai, A.; Murata, A.; Nakatani, K. Bull. Chem. Soc. Jpn. 2014, 87, 1013-1015.

(156) Modulation of binding properties of amphiphilic DNA containing multiple dodecyl phosphotriester linkages to lipid bilayer membrane, Makishi, S.; Shibata, T.; Okazaki, M.; Dohno, C.; Nakatani, K. Bioorg. Med. Chem. Lett. 2014, 24, 3578-3581.

(155) Detection of hepatitis C virus by single-step hairpin primer RT-PCR, Takei, F.; Tani, H.; Matsuura Y.; Nakatani, K. Bioorg. Med. Chem. Lett. 2014, 24, 394-396.

(154) Formation of Ligand-Assisted Complex of Two RNA Hairpin Loops, Hong, C.; Otabe, T.; Matsumoto, S.; Dohno, C.; Murata, A.; Hagihara, M.; Nakatani, K. Chem. Eur. J. 2014, 20, 5282-5287.

2013

(153) High speed DNA denaturation using microheating devices, Furuhashi, M.; Okamoto, Y.; Onoshima, D.; Ohshiro, T.; Ryuzaki, S.; Yokota, K.; Tsutsui, M.; Taniguchi, M.; Nakatani, K.; Baba, Y.; Kawai, T. Appl. Phys. Lett. 2013, 103, 023112.

(152) Facile electrochemical biosensor based on a new bifunctional probe for label-free detection of CGG trinucleotide repeat, He, H.; Xia, J. P.; Peng, X. Q.; Chang, G.; Zhang, X. H.; Wang, Y. F.; Nakatani, K.; Lou, Z. W.; Wang, S. F. Biosensors and Bioelectronics 2013, 49, 282-289.

(151) Fluorescent indicator displacement assay of ligands targeting 10 microRNA precursors. Murata, A.; Harada, Y.; Fukuzumi, T.; Nakatani, K. Bioorg. Med. Chem. 2013, 21, 7101-7106.

(150) A synthetic riboswitch that operates using a rationally designed ligand-RNA pair. Dohno, C.; Kohyama, I.; Kimura, M.; Hagihara, M.; Nakatani, K. Angew. Chem. Int. Ed. 2013, 52, 9976-9979.

(149) G-quadruplex formation of entirely hydrophobic DNA in organic solvents. Shibata, T.; Dohno, C.; Nakatani, K. Chem. Commun. 2013, 49, 5501-5503.

(148) Ligand-inducible formation of RNA pseudoknot. Matsumoto, S., Hong, C; Otabe, T.; Murata, A.; Nakatani, K. Bioorg. Med. Chem. Lett. 2013, 23, 3539-3541.

(147) Ligand-induced electron spin-assembly on a DNA tile. Atsumi, H.; Nakazawa, S.; Dohno, C.; Sato, K.; Takui, T.; Nakatani, K. Chem. Commun. 2013, 49, 6355-6458. Front Cover

(146) A Novel DANP-Coupled Hairpin RT-PCR for Rapid Detection of Chikungunya Virus. Chen, H.; Takei, F.; Koay, E. S.-C.; Nakatani, K.; Chu, J. J. H. J. Mol. Diagn. 2013, 15, 227-233.

(145) Selective recognition of G-G mismatch using the double functional probe with electrochemical active ferrocenyl, He, H.; Xia, J.; Chang, G.; Peng, X.; Lou, Z.; Nakatani, K.; Zhou, X.; Wang, S. Biosensors and Bioelectronics, 2013, 42, 36-40.

(144) A dimeric form of N-Methoxycarbonyl-2-amino-1,8-naphthyridine bound to the A-A mismatch in the CAG/CAG base triad in dsRNA. Nakatani, K.; Toda, M.; He, H. Bioorg. Med. Chem. Lett. 2013, 23, 558-561.

(143) Xanthone derivatives as potential inhibitors of miRNA processing by human Dicer: Targeting secondary structures of pre-miRNA by small molecules. Murata, A.; Fukuzumi, T.; Umemoto, S.; Nakatani, K. Bioorg. Med. Chem. Lett. 2013, 23, 252-255.

(142) Triethynylmethane: A Molecular Unit Inducing Excimer-Like Emission in Aggregated States of Hydrocarbon Fluorophores. Otabe, T.; Matsumoto, S.; Nakagawa, H.; Hong, C.; Dohno, C.; Nakatani, K. Tetrahedron. Lett. 2013, 54, 143-146.

2012

(141) Activation of prokaryotic translation by antisense oligonucleotides binding to coding region of mRNA. Hayashi, G.; Hong, C.; Hagihara, M.; Nakatani, K. Biochem. Biophys. Res. Commun. 2012, 429, 105-110.

(140) Assembly of a small DNA rectangular parallelepiped block into higher order nanostructures. Nakagawa, H.; Toda, M.; Atsumi, H.; Hagihara, M.; Hayashi-Nishino, M.; Dohno, C.; Nakatani, K. Chem. Lett. 2012, 41, 1550-1552.

(139) Amphiphilic DNA duplex stabilized by hydrophobic zipper. Dohno, C.; Shibata, T.; Okazaki, M.; Makishi, S.; Nakatani, K. Eur. J. Org. Chem. 2012, 5317-5323.

(138) Competitive allele-specific hairpin primer PCR for extremely high allele discrimination in typing of single nucleotide polymorphism, Takei, F.; Igarashi, M.; Oka, Y.; Koga, Y.; Nakatani, K. ChemBioChem 2012, 13, 1409-1412.

(137) Structure-activity studies on the fluorescent indicator in the displacement assay for the screening of small molecules binding to RNA. Umemoto, S.; Im, S.; Zhang, J.; Hagihara, M.; Murata, A.; Harada, Y.; Fukuzumi, T.; Wazaki, T.; Sasaoka, S.; Nakatani, K. Chem. Eur. J. 2012, 18, 9999-10008.

(136) A Small Molecule Regulates Hairpin Structures in d(CGG) Trinucleotide Repeats. Hagihara, M.; He, H.; Kimura, M.; Nakatani, K. Bioorg. Med. Chem. Lett. 2012, 22, 2000-2003.

(135) Naphthyridine tetramer with a preorganized structure for 1:1 binding to a CGG/CGG sequence. Dohno, C.; Kohyama, I.; Hong, C.; Nakatani, K. Nucleic. Acids. Res. 2012, 40, 2771-2781. Open Access.

(134) Tandem Arrays of TEMPO and Nitronyl Nitroxide Radicals with Designed Arrangements on DNA, Atsumi, H.; Maekawa, K.; Nakazawa, S.; Shiomi, D.; Sato, K.; Kitagawa, M.; Takui, T. and Nakatani, K. Chem. Eur. J. 2012, 18, 178-183.

2011

(133) Small Molecule Modulates Hairpin Structures in CAG Trinucleotide Repeats. Hagihara, M.; He, H.; Nakatani, K. ChemBioChem. 2011, 12, 1686-1689. Front Cover.

(132) Interstrand Cross-Link for Discrimination of Methylated Cytosines. Dohno, C.; Shibata, T.; Nakatani, K. Chem. Lett. 2011, 40, 852-854.

(131) Control of DNA hybridization by photoswitchable molecular glue, Dohno, C.; Nakatani, K. Chem. Soc. Rev. 2011, 40, 5718-5729.

(130) Molecular-Glue-Triggered DNA Assembly to Form a Robust and Photoresponsive Nano-Network, Wang, C.; Pu, F.; Lin, Y.; Ren, J.; Dohno, C.; Nakatani K.; Qu, X. Chem. Eur. J. 2011, 17, 8189-8197.

(129) Ligand-Assisted Complex Formation of Two DNA Hairpin Loops. Hong, C.; Hagihara, M.; Nakatani, K. Angew. Chem. Int. Ed. 2011, 50, 4390-4393.

(128) Ligand Inducible Assembly of a DNA Tetrahedron. Dohno, C.; Atsumi, H.; Nakatani, K. Chem. Commun. 2011, 47, 3499-3501.

2010

(127) Antisense-Induced Guanine Quadruplexes Inhibit Reverse Transcription by HIV-1 Reverse Transcriptase. Hagihara, M.; Yamauchi, L.; Seo, A.; Yoneda, K.; Senda, M.; Nakatani, K. J. Am. Chem. Soc. 2010, 132, 11171-11178.

(126) Discrimination of N6-methyl adenine in a specific DNA sequence. Dohno, C.; Shibata, T.; Nakatani, K. Chem. Commun. 2010, 46, 5530-5532.

(125) Non-covalent assembly of TEMPO radicals pair-wise embedded on a DNA duplex. Atsumi, H.; Maekawa, K.; Nakazawa, S.; Shiomi, D.; Sato, K.; Kitagawa, M.; Takui, T. and Nakatani, K. Chem. Lett. 2010, 39, 556-557. Editor's Choice.

(124) Transformation of cytosine to uracil in single-stranded DNA via their oxime sulfonates. Oka, Y.; Takei, F.; Nakatani, K. Chem. Commun. 2010, 46, 3378-3380.

(123) Fluorescent Indicator-Displacement Assay for Ligand-RNA Interactions, Zhang, J.; Umemoto, S.; Nakatani, K. J. Am. Chem. Soc. 2010, 132, 3660-3661.

(122) A Reverse Transcriptase Stop Assay Revealed Diverse Quadruplex Formations in UTRs in mRNA, Hagihara, H.; Yoneda, K.; Yabuuchi, H.; Okuno, Y.; Nakatani, K. Bioorg. Med. Chem. Lett. 2010, 20, 2350-2353.

(121) Programmed Assembly of Organic Radicals on DNA. Maekawa, K.; Nakazawa, S.; Atsumi, H.; Shiomi, D.; Sato, K.; Kitagawa, M.; Takui, T.; Nakatani, K. Chem. Commun. 2010, 46, 1247-1249.

2009

(120) Secondary Structure-Inducible Ligand Fluorescence Coupled with PCR, Takei, F.; Igarashi, M.; Hagihara, M.; Oka, Y.; Soya, Y.; Nakatani, K. Angew. Chem. Int. Ed. 2009, 48, 7822-7824.

(119) Recognition of Mismatched Base Pairs in DNA, Nakatani, K. Bull. Chem. Soc. Chem. 2009, 82, 1055-1069.

(118) A Light-Driven, Supramolecular Optical Switch, Uno, S.; Dohno, C.; Bittermann, H.; Malinovskii, V. L.; Häner, R.; Nakatani, K. Angew. Chem. Int. Ed. 2009, 48, 7362-7365.

(117) Small molecule affecting the replication of trinucleotide repeat d(GAA)n, He, H.; Hagihara, M.; Nakatani, K. Chem. Eur. J. 2009, 15, 10641-10648.

(116) Photoswitchable Unsymmetrical Ligand for DNA Hetero-Mismatches, Dohno, C.; Yamamoto, T.; Nakatani, K. Eur. J. Org. Chem. 2009, 4051-4058.

(115) Synthesis and Reaction of DNA Oligomers Containing Modified Cytosines Related to Bisulfite Sequencing, Oka, Y.; Peng, T.; Takei, F.; Nakatani, K. Org. Lett. 2009, 11, 1377-1379.

(114) The effect of linker length on binding affinity of a photoswitchable molecular glue for DNA, Dohno, C.; Uno, S.; Sakai, S.; Oku, M.; Nakatani, K. Bioorg. Med. Chem. 2009, 17, 2536-2543.

(113) RNA Aptamers That Reversibly Bind Photoresponsive Azobenzene-Containing Peptides, Hayashi, G.; Hagihara, M.; Nakatani, K. Chem. Eur. J. 2009, 15, 424-432.

2008

(112) Dimer of 2,7-diamino-1,8-naphthyridine for the detection of mismatches formed by pyrimidine nucleotide bases, Kobori, A.; Nakatani, K. Bioorg. Med. Chem. 2008, 16, 10338-10344.

(111) Site-specific binding of chelerythrine and sanguinarine to single pyrimidine bulges in hairpin DNA, Bai, L.-P.; Cai, Z.; Zhao, Z.-Z.; Nakatani, K.; Jiang, Z.-H. Anal. Bioanal. Chem. 2008, 392, 709-716.

(110) Ligand Binding to Tandem G-quadruplex from Human Telomeric DNA, Bai, L.-P.; Hagihara, M.; Jiang, Z.-H.; Nakatani, K. ChemBioChem 2008, 9, 2583-2587.

(109) DNA Labeling by Ligand Inducible Secondary Structure, Peng, T.; He, H.; Hagihara, M.; Nakatani, K. ChemBioChem 2008, 9, 1893-1897.

(108) Genotyping by allele-specific L-DNA-tagged PCR, Hayashi, G.; Hagihara, M.; Nakatani, K. J. Biotechnol. 2008, 135, 157-160.

(107) Synthesis of Dimeric 2-Amino-1,8-naphthyridine and Related DNA-Binding Molecules, Nakatani, K.; He, H.; Uno, S.; Yamamoto, T.; Dohno, C. Current Protocols in Nucleic Acid Chemistry 2008, Unit 8.6, 1-21.

(106) The crystallographic study of left-handed Z-DNA d(CGCGCG)2 and thermine complexes crystallized at various temperatures and at various concentration of cations, Ohishi, H.; Odoko, M.; Zhou, D.-Y.; Tozuka, Y.; Okabe, N.; Nakatani, K.; Ishida, T.; Grzeskowiak, K. Biochem. Biophys. Res. Commun. 2008, 368, 382-387.

(105) Polyamines stabilize left-handed Z-DNA: Using X-ray crystallographic analysis, we have found a new type of polyamine (PA) that stabilizes left-handed Z-DNA, Ohishi, H.; Odoko, M.; Grzeskowiak, K.; Hiyama, Y.; Tsukamoto, K.; Maezaki, N.; Ishida, T.; Tanaka, T.; Okabe, N.; Fukuyama, K.; Zhou, D.-Y.; Nakatani, K. Biochem. Biophy. Res. Commun. 2008, 366, 275-280.

(104) Ligand-Stabilized Hairpin Structures Interfered with Elongation of Human Telomere, Hagihara, M.; Goto, Y.; Nakatani, K. ChemBioChem 2008, 9, 510-513.

2007

(103) Photoswitchable Molecular Glue for DNA, Dohno, C.; Uno, S.; Nakatani, K. J. Am. Chem. Soc. 2007, 129, 11898-11899.

(102) Photoregulation of a Peptide-RNA Interaction on a Gold Surface, Hayashi, G.; Hagihara, M.; Dohno, C.; Nakatani, K. J. Am. Chem. Soc. 2007, 129, 8678-8679.

(101) Emission of Characteristic Fluorescence from the Ligand-Cytosine Complex in U_A/ACU Bulged RNA Duplex, Zhang, J.; Takei, F.; Nakatani, K. Bioorg. Med. Chem. 2007, 15, 4813-4817.

(100) Analysis of mismatched DNA by mismatch binding ligand (MBL)-Sepharose affinity chromatography, Goto, Y.; Suda, H.; Kobori, A.; Nakatani, K. Anal. Bioanal. Chem. 2007, 388, 1165-1173.

(99) The rare crystallographic structure of d(CGCGCG)2: The natural spermidine molecule bound to the minor groove of left-handed Z-DNA d(CGCGCG)2 at 10 C. Ohishi, H.; Tozuka, Y.; Zhou, D.-Y.; Ishida, T.; Nakatani, K. Biochem. Biophy. Res. Commun. 2007, 358, 24-28.

(98) Small molecule binding to non-Quadruplex form of the Human Telomeric Sequence, Goto, Y.; Hagihara, S.; Hagihara, M.; Nakatani, K. ChemBioChem 2007, 8, 723-726.

(97) Exploiting Small Molecule Binding to DNA for the Detection of Single-Nucleotide Mismatches and Their Base Environment, Li, X.; Song, H.; Nakatani, K.; Kraatz, H.-B. Anal. Chem. 2007, 79, 2552-2555.

(96) Allele Specific C-Bulge Probes with One Unique Fluorescent Molecule Discriminate the Single Nucleotide Polymorphism in DNA, Takei, F.; Suda, H.; Hagihara, M.; Zhang, J.; Kobori, A.; Nakatani, K. Chem. Eur. J. 2007, 13, 4452-4457.

(95) Bidirectional Control of Gold Nanoparticle Assembly by Turning On and Off DNA Hybridization with Thermally Degradable Molecular Glue, Peng, T.; Dohno, C.; Nakatani, K. ChemBioChem 2007, 8, 483-485.

(94) Detection of L-DNA-Tagged PCR Products by Surface Plasmon Resonance Imaging, Hayashi, G.; Hagihara, M.; Kobori, A.; Nakatani, K. ChemBioChem 2007, 8, 169-17.

2006

(93) Mismatch binding ligands function as molecular glue of DNA, Peng, T.; Dohno, C.; Nakatani, K. Angew. Chem. Int. Ed. 2006, 45, 5623-5626.

(92) Evaluation of mismatch-binding ligands as inhibitors for Rev-RRE interaction, Nakatani, K.; Horie, S.; Goto, Y.; Kobori, A.; Hagihara, S. Bioorg. Med. Chem. 2006, 14, 5384-5388.

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2005

(91) Binding of Naphthyridine Carbamate Dimer to the (CGG)n Repeat Resulted in the Disruption of the G-C Base Pairing, Peng, T.; Nakatani, K. Angew. Chem. Int. Ed. 2005, 44, 7280−7283.

(90) Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats, Nakatani, K.; Hagihara, S.; Goto, Y.; Kobori, A.; Hagihara, M.; Hayashi, G.; Kyo, M.; Nomura, M.; Mishima, M.; Kojima, C. Nature Chemical Biology 2005, 1, 39−43.

(89) N,N'-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA, Suda, H.; Kobori, A.; Zhang,? J.; Hayashi,? G.; Nakatani, K. Bioorg. Med. Chem. 2005, 13, 4507−4512.

(88) A new ligand binding to G-G mismatch having improved thermal and alkaline stability, Peng, T.; Murase, T.; Goto, Y.; Kobori, A.; Nakatani, K. Bioorg. Med. Chem. Lett. 2005, 15, 259−262.

2004

(87) 2-Ureidoquinoline: a useful molecular element for stabilizing single cytosine ant thymine bulges, Kobori, A.; Murase, T.; Suda, H.; Saito, I.; Nakatani, K. Bioorg. Med. Chem. Lett. 2004, 14, 3431−3433.

(86) The binding of Guanine-Guanine Mismatched DNA to Naphthyridine Dimer Immobilized Sensor Surfaces: Kinetic Aspects, Nakatani, K.; Kobori, A.; Kumasawa, H.; Goto, Y.; Saito, I. Bioorg. Med. Chem. 2004, 12, 3117−3123.

(85) Solvent Effects on the Suppression of Oxidative Decomposition of Guanine by Phenyl Group Attachment in DNA, Yokojima, S.; Okada, A.; Yanoi, W.; Yoshiki, N.; Kurita, N.; Tanaka, S.; Nakatani, K. J. Phys. Chem. B 2004, 108, 7500−7505.

(84) Highly Sensitive Detection of GG Mismatched DNA by Surfaces Immobilized Naphthyridine Dimer through Poly(ethylene oxide) Linkers, Nakatani, K.; Kobori, A.; Kumasawa, H.; Saito, I. Bioorg. Med. Chem. Lett. 2004, 14, 1105−1108.

(83) Detection of Guanine-Adenine Mismatches by Surface Plasmon Resonance Sensor carrying Naphthyridine-Azaquinolone Hybrid on the Surface, Hagihara, S.; Kumasawa, H.; Goto, Y.; Hayashi, G.; Kobori, A.; Saito, I.; Nakatani, K. Nucleic Acids Res. 2004, 32, 278−286.

(82) The SPR Sensor Detecting The Cytosine-Cytosine Mismatches, Kobori, A.; Horie, S.; Suda, H.; Saito, I.; Nakatani, K. J. Am. Chem. Soc.2004, 126, 557−562.

2003

(81) Hole Trapping at N6-Cyclopropyldeoxyadenosine Suggests a Direct Contribution of Adenine Bases to Hole Transport through DNA, Dohno, C.; Ogawa, A.; Nakatani, K.; Saito, I. J. Am. Chem. Soc. 2003, 125, 10154−10155.

(80) Affinity Labeling of a Single Guanine Bulge, Nakatani, K.; Horie, S.;?Saito, I., J. Am. Chem. Soc. 2003, 125, 8972−8973.

(79) Formation and Destruction of the Guanine Quartet in Solution Observed by Cold-Spray Ionization Mass Spectrometry, Sakamoto, S.; Nakatani, K.; Saito, I., Yamaguchi, K., Chem. Commun. 2003, 788−789.

(78) Assessment of the Sequence Dependency for the Binding of 2-Aminonaphthyridine to the Guanine Bulge, Nakatani, K.; Horie, S.; Murase T.; Hagihara, S.;?Saito, I., Bioorg. Med. Chem. 2003, 11, 2347−2353.

(77) Induction of a Remarkable Conformational Change in a Human Telomeric Sequence by the Binding of Naphthyridine Dimer: Inhibition of the Elongation of a Telomeric Repeat by Telomerase, Nakatani, K.; Hagihara, S.;?Sando, S.;?Sakamoto, S.; Yamaguchi, K.; Maesawa, C.; Saito, I., J. Am. Chem. Soc. 2003, 125, 662−666.

2002

(76) Guanine of the Third Strand of C.G*G Triplex Serves as an Effective Hole Trap, Dohno, C.; Nakatani, K.; Saito, I. J. Am. Chem. Soc. 2002, 124, 14580−14585.

(75) Chemically Induced Hairpin formation in DNA Monolayers, Smith, E. A.; Kyo M.; Kumasawa. H.; Nakatani, K.; Saito, I.; Corn, R. M. J. Am. Chem. Soc. 2002, 124, 6810−6811.

(74) N2-Phenyldeoxyguanosine: Modulation of the Chemical Property of Deoxyguanosine toward One Electron Oxidation in DNA, Nakatani, K.; Dohno, C.; Saito, I. J. Am. Chem. Soc. 2002, 124, 6802−6803.

(73) Suppression of DNA-Mediated Charge Transport by BamH I Binding, Nakatani, K.; Dohno, C.; Ogawa, A.; Saito, I. Chem. Bio. 2002, 9, 361−366.

(72) Photochemistry of Benzophenone Immobilized in a Major Groove of DNA: Formation of Thermally Reversible Interstrand Cross-link, Nakatani, K.; Yoshida, T.; Saito, I. J. Am. Chem. Soc. 2002, 124, 2118−2119.

2001

(71) Recognition of Guanine-Guanine Mismatch by Dimeric Form of 2-Amino-1,8-naphthyridine, Nakatani, K.; Sando, S.; Kumasawa, H.; Kikuchi, J.; Saito, I. J. Am. Chem. Soc. 2001, 123, 12650−12657.

(70) Improved Selectivity for the Binding of Naphthyridine Dimer to Guanine-Guanine Mismatch, Nakatani, K.; Sando, S.; Saito, I. Bioorg. Med. Chem. 2001, 9, 2381−2385.

(69) Design of Hole-Trapping Nucleobase: Termination of DNA Mediated Hole Transport at N2-Cyclopropyldeoxyguanosine, Nakatani, K.; Dohno, C.; Saito, I. J. Am. Chem. Soc. 2001, 123, 9681−9682.

(68) Sequence Selectivity for the Guanine Alkylation by DNA-Alkylating Intercalators, Nakatani, K.; Saito, I. J. Synth. Org. Chem. Jpn. 2001, 59, 670−679.

(67) Selective Intercalation of Charge Neutral Intercalators into GG and CG Steps: Implication of HOMO-LUMO Interaction for Sequence Selective Drug Intercalation into DNA, Nakatani, K.; Matsuno, T.; Adachi, K.; Hagihara, S.; Saito, I. J. Am. Chem. Soc. 2001, 123, 5695−5702.

(66) Specific binding of 2-amino-1,8-naphthyridine into a single guanine bulge as evidenced by photooxidation of GG doublet, Nakatani, K.; Sando, S.; Yoshida, K.; Saito, I. Bioorg. Med. Chem. Lett. 2001, 11, 335−337.

(65) Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance assay, Nakatani, K.; Sando, S.; Saito, I. Nat. Biotechnol. 2001, 19, 51−55.

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2000

(64) Site Selective Generation of Guanine Cation Radical inDuplex DNA: Modulation of the Direction of Hole Transport, Nakatani, K.; Dohno, C.; Saito, I. Tetrahedron Lett. 2000, 41, 10041−10045.

(63) Site-Selective DNA Alkylation of GG Steps by Naphthaldiimide Derivatives Possessing Enantiomeric Epoxide, Okamoto, A.; Nakamura, T.; Yoshida, K.; Nakatani, K.; Saito, I. Org.?Lett. 2000, 2, 3249−3251.

(62) Site Selective Formation of Thymine Glycol-Containing Oligodeoxynucleotides by Oxidation with Osmium Tetroxide and Bipyridine-Tethered Oligonucleotide, Nakatani, K.; Hagihara, S.; Sando, S.; Miyazaki, H.; Tanabe, K.; Saito, I. J. Am. Chem. Soc. 2000, 122, 6309−6310.

(61) Modulation of DNA-Mediated Hole Transport Efficiency by Changing Superexchange Electronic Interaction, Nakatani, K.; Dohno, C.; Saito, I. J. Am. Chem. Soc. 2000, 122, 5893−5894.

(60) Mapping of the HOMO of Duplex DNA, a New Landmark for DNA Properties, Saito, I.; Nakamura, T.; Nakatani, K. J. Am. Chem. Soc. 2000, 122, 3001−3006.

(59) Recognition of a Single Guanine Bulge by 2-Acylamino-1,8-naphthyridine, Nakatani, K.; Sando, S.; Saito, I. J. Am. Chem. Soc. 2000, 122, 2172−2177.

1999

(58) Chemistry of Sequence Dependent Remote Guanine Oxidation: Photoreaction of Duplex DNA containing Cyanobenzophenone Substituted Uridine, Nakatani, K.; Dohno, C.; Saito, I. J. Am. Chem. Soc. 1999, 121, 10854−10855.

(57) Tandem Cyclization Involving Carbene as an Intermediate. Photochemical Reactions of Substituted 1,2-Diketones Conjugated with Ene-Yne, Nakatani, K.; Adachi, K.; Tanabe, K.; Saito, I. J. Am. Chem. Soc. 1999, 121, 8221−8228.

(56) Water-soluble 2-Amino-1,8-naphthyridine as a Novel DNA Binding Photosensitizer for One-Electron Oxidation of DNA, Nakatani, K.; Sando, S.; Yoshida, K.; Saito, I. Tetrahedron Lett. 1999, 40, 6029−6032.

(55) Specific Alkylation of Guanine Opposite to a Single Nucleotide Bulge: A Chemical Probe for Bulged Structure of DNA, Nakatani, K.; Okamoto, A.; Saito, I. Angew. Chem. Int. Ed. 1999, 38, 3378−3381.

(54) Synthesis of DNA Oligomers Containing Modified Uracil Possessing Electron-Accepting Benzophenone Chromophore, Nakatani. K.; Dohno, C.; Saito, I. J. Org. Chem. 1999, 64, 6306−6311.

(53) Mechanistic Studies on Photoinduced Cross-Linking and Specific? Cleavage at Guanine by Dibenzoyldiazomethane-Oligodeoxynucleotide Conjugate, Nakatani, K.; Sando, S.; Saito, I. Bioorganic Chemistry 1999, 27, 227−237.

1998

(52) Mapping of the Hot Spots for DNA Damage by One-Electron Oxidation: Efficacy of GG Doublets and GGG Triplets as a Trap, Satio, I.; Nakamura T.; Nakatani, K.; Yoshioka, Y.; Yamaguchi, K.; Sugiyama, H. J. Am. Chem. Soc. 1998, 120, 12686−12687.

(51) Highly Selective DNA Alkylation at 5' Side G of 5' GG 3' Sequence by an Aglycon Model of Pluramycin Antibiotics through Preferential Intercalation into GG Step, Nakatani, K.; Okamoto, A.; Matsuno, T.; Saito, I. J. Am. Chem. Soc. 1998, 120, 11219−11225.

(50) p-Cyano Substituted 5-Benzoyldeoxyuridine as a Novel Electron-Accepting Nucleobase for One-Electron Oxidaiton of DNA, Nakatani, K.; Fujisawa, K.; Dohno, C.; Nakamura, C.; Saito, I. Tetrahedron Lett. 1998, 39, 5995−5998.

(49) p-Cyano Substituted Benzophenone as an Excellent Photophore for One-Electron Oxidation of DNA, Nakatani, K.; Dohno, C.; Nakamura, T.; Saito, I. Tetrahedron Lett. 1998, 39, 2779−2782.

1997

(48) Synthesis of ABC Ring Analog of Kapurimycin A3 as an Effective DNA Alkylating Agent, Nakatani, K.; Okamoto, A.; Saito I. Angew. Chem. 1997, 109, 2881−2883. Angew. Chem. Int. Ed. Engl. 1997, 36, 2794−2797.

(47) Guanine Specific DNA Cleavage by Photoirradiation of Dibenzoyldiazomethane-Oligonucleotide Conjugates, Nakatani, K.; Shirai, J.; Sando, S.; Saito, I. J. Am. Chem. Soc. 1997, 119, 7626−7635.

(46) Dibenzoyldiazomethane-Acridine?Conjugate: A Novel DNA Photofootprinting Agent, Nakatani, K.; Shirai, J.; Sando, S.; Saito, I. Tetrahedron Lett. 1997, 38, 6047−6050.

(45) Highly Efficient Photochemical Generation of o-Quinone Methide from Mannich Bases of Phenol Derivatives, Nakatani, K.; Higashida, N.; Saito, I. Tetrahedron Lett. 1997, 38, 5005−5008.

(44) Novel Synthesis of Bifurans via Furan-Forming Photocyclization of a-Diketones Conjugated with Ene-Yne, Nakatani, K.; Tanabe, K.; Saito I. Tetrahedron Lett. 1997, 38, 1207−1210.

1996

(43) 6-Endo- and 5-Exo-digonal Cyclization of o-Hydroxy Ethynyl Ketones: A Key Step for Highly Selective Benzopyranone Formation, Nakatani, K.; Okamoto, A.; Saito, I. Tetrahedron 1996, 52, 9427−9436.

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1995

(42) New Aspects of a-Diazocarbonyl Compounds.? From Construction of the Novel Carbon Framework to the Photoinduced DNA Cleavage, Nakatani, K. J. Synth. Org. Chem. Jpn. 1995, 53, 1068−1076.

(41) a-Diazo Ketones as Photochemical DNA-Cleavers: A Mimic for Radical Generating System of Neocarzinostatin Chromophore, Nakatani, K.; Maekawa, S.; Tanabe, K.; Saito, I. J. Am. Chem. Soc. 1995, 117, 10635−10644.

(40) Photogeneration of Highly Electrophilic Benzoylketene from Dibenzoyldiazomethane in Aqueous Solvents: Reaction with Amino Acids and DNA Cleavage, Nakatani, K.; Shirai, J.; Tamaki, R.; Saito, I. Tetrahedron Lett. 1995, 36, 5363−5366.

(39) Photoinduced DNA cleavage via Electron Transfer: Demonstration That Guanine Residues Located 5' to guanine are the Most Electron-Donating Sites, Saito, I.; Takayama, M.; Sugiyama, H.; Nakatani, K.; Tsuchida, A.; Yamamoto, M. J. Am. Chem. Soc. 1995, 117, 6406−6407.

(38) Intramolecular Cooperative Reactions of 1,2-Bis(diazoketone)s. The First Synthesis of trans-Hydro-1H-2-inden-1-ones, Nakatani, K.; Takada, K.; Isoe S. J. Org. Chem. 1995, 60, 2466−2473.

1994

(37) Synthesese and Theoretical Studies of Exocyclic g-Oxoalkenyltrimethylsilanes. An Approach to the Stereodefined Exocyclic Tetrasubstituted Alkenes, Nakatani, K.; Izawa, T.; Isoe, S. J. Org. Chem. 1994, 59, 5961−5969.

(36) Highly Efficient Synthesis of 2-Substituted 4H-Chromen-4-ones by means of F?-Induced 6-Endo-Digonal Cyclization of o-Silyloxyphenyl Ethynyl Ketone Derivatives, Nakatani, K.; Okamoto, A.; Yamanuki, M.; Saito, I. J. Org. Chem. 1994, 59, 4360−4361.

(35) Synthesis and Cytotoxicity of Natural (+)-Duocarmycin A and Its Three Possible Diastereomers, Nakatani, K.; Fukuda, Y.; Terashima, S. Pure Appl. Chem. 1994, 66, 2255−2258.

(34) Synthetic Studies on Quinocarcin and Its Related Compounds. 5. Synthesis and Antitumor Activity of Various Structual Types of Quinocarcin Congeners, Kato, T.; Kirihara, M.; Yoshino, T.; Tamura, T.; Ikeuchi, F.; Nakatani, K.; Matsuda, F.; Yamada, K.; Gomi, K.; Ashizawa, T.; Terashima, S. Tetrahedron 1994, 50, 6259−6270.

(33) Synthetic Studies on Quinocarcin and Its Related Compounds. 2. Synthesis of Enantiomeric Pair of the ABC Ring System of Quinocarcin, Saito, S.; Tanaka, K.; Nakatani, K.; Matsuda, F.; Kato, T.; Terashima, S. Tetrahedron 1994, 50, 6209−6220.

(32) Synthetic Studies on the Key Component of the New Generation of Quinolonecarboxylic Acid, DU-6859. 2. Asymmetric Synthesis of (1R, 2S)-2-Fluorocyclopropylamine, Akiba, T.; Tamura, O.; Hashimoto, M.; Kobayashi, Y.; Katoh, T.; Nakatani, K.; Kamada, M.; Hayakawa, I.; Terashima, S. Tetrahedron 1994, 50, 3905−3914.

(31) Synthetic Studies on the Key Component of the New Generation of Quinolonecarboxylic Acid, DU-6859. 1. Synthesis of (1R, 2S)-2-Fluorocyclopropylamine by the Use of Optical Resolution, Tamura, O.; Hashimoto, M., Kobayashi, Y.; Katoh, T.; Nakatani, K.; Kamada, M.; Hayakawa, I.; Akiba, K.; Terashima, S. Tetrahedron 1994, 50, 3889−3904.

(30) Synthetic Studies on Duocarmycin. 2. Synthesis and Cytotoxicity of Natural (+)-Duocarmycin A and Its Three Possible Stereoisomers, Fukuda, Y.; Nakatani, K.; Terashima, S. Tetrahedron 1994, 50, 2809−2820.

(29) Synthetic Studies on Duocarmycin. 1. Total synthesis of dl-Duocarmycin A and Its 2-Epimer, Fukuda, Y.; Itoh, Y.; Nakatani, K.; Terashima, S. Tetrahedron 1994, 50, 2793−2808.

(28) Photoinduced DNA Cleavage by Designed Molecules with Conjugated Ene-Yne-Ketene Functionalities, Nakatani, K.; Isoe, S.; Maekawa, S.; Saito, I. Tetrahedeon Lett. 1994, 35, 605−608.

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1993

(27) Crystal Structure of (2S)-2-Hydroxy-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-butyn-1-yl-2,2-dimethylpropanoate, Hirayama, N.; Nakatani, K.; Arai, K.; Matsuda, F.; Terashima, S. Anal. Sciences 1993, 9, 885−886.

(26) Absolute Configuration of Novel Marine Diterpenoid Udoteatrial Hydrate. Synthesis and Cytotoxicities of ent-Udoteatrial Hydrate and Its Analogues, Ge, Y.; Kondo, S.; Katsumura, S.; Nakatani, K.; Isoe, S. Tetrahedron 1993, 49, 10555−10576.

(25) Novel Stereocontrolled Syntheses of Exocyclic g-Oxovinyltrimethylsilanes. A Potential Route for Stereodefined Exocyclic Tetrasubstituted Alkenes, Nakatani, K.; Izawa, T.; Odagaki, Y.; Isoe, S. J. Chem. Soc., Chem. Commun. 1993, 1365−1367.

(24) Synthesis of Asperuloside Agulucon Silyl Ether and Garjasmine from (+)-Genipin via Gardenoside Agulucon Bis(silyl ether) as a Common Intermediate, Nakatani, K.; Shimano, K.; Hiraishi, A.; Han, Q.; Isoe, S. Bull. Chem. Soc. Jpn. 1993, 66, 2646−2652.

(23) Cytotoxicity of ent-Udoteatrial Diacetate and Its Analogues, Ge, Y.; Nakatani, K.; Isoe, S. Bioorg. Med. Chem. Lett. 1993, 3, 1085−1088.

(22) Synthesis of the Antipode of Udoteatrial Hydrate Using (+)-genipin as a Chiral Building Block: Determination of the Absolute Configuration of Udoteatrial Hydrate, Ge, Y.; Kondo, S.; Katsumura, S.; Nakatani, K.; Isoe, S. Tetrahedron Lett. 1993, 34, 2621−2624.

(21) Novel Synthesis of trans-Hydroindenones by Thermal Reaction of a,w-bis(diazo)diketones, Nakatani, K.; Takada, K.; Odagaki, Y.; Isoe, S. J. Chem. Soc., Chem. Commun. 1993, 556−557.

(20) Synthetic Studies on the Compounds Related to Neocarzinostatin Chromophore. 3. Novel Synthesis of a Chiral Cyclic Dienediyne System, Nakatani, K.; Arai, K.; Terashima, S.; Tetrahedron 1993, 49, 1901−1912.

1992

(19) Synthesis of Asperuloside Agulucon Silyl Ether and Garjasmine from (+)-Genipin via Gardenoside Agulucon Disilyl Ether as a Common Intermediate, Nakatani, K.; Hiraishi, A.; Han, Q.; Isoe, S. Chem. Lett. 1992, 1851−1854.

(18) DNA Alkylation Properties of the Duocarmycins: (+)-Duocarmycin A, Epi-(+)-Duocarmycin A, Ent-(?)- Duocarmycin A and Ent, Epi-(?)-Duocarmycin A, Boger, D. L.; Yun, W.; Terashima, S.; Fukuda, Y.; Nakatani, K.; Kitos, P. A.; Jin, Q. BioMed. Chem. Lett. 1992, 2, 759−765.

(17) Synthesis and Cytotoxicity of Enantiomeric Pairs of Duocarmycin A and Its 2-Epimer, Fukuda, Y.; Nakatani, K.; Terashima, S. BioMed. Chem. Lett. 1992, 2, 755−758.

(16) Asymmetric Synthesis of (1R, 2S)-2-Fluorocyclopropylamine, the Key Component of the New Generation of Quinolonecarboxylic Acid, DU-6859, Tamura, O.; Hashimoto, M.; Kobayashi, Y.; Katoh, T.; Nakatani, K.; Kamada, M.; Hayakawa, I.; Akiba, K.; Terashima, S. Tetrahedron Lett. 1992, 33, 3487−3490.

(15) Synthesis and Optical Resolution of dl-cis-2-Fluolo-cyclopropylamine, the Key Component of the New Generation of Quinolonecarboxylic Acid, DU-6859, Tamura, O.; Hashimoto, M.; Kobayashi, Y.; Katoh, T.; Nakatani, K.; Kamada, M.; Hayakawa, I.; Akiba, K.; Terashima, S. Tetrahedron Let.t 1992, 33, 3483−3486.

(14) Synthetic Studie on the Compounds Related to Neocarzinostatin Chromophore. 2. Synthesis of the Open-Chain (E)- and (Z)-Dienediyne Systems and Its Application to the Synthesis of a Strain-released Cyclic Analogues, Nakatani, K.; Arai, K.; Yamada, K.; Terashima, S. Tetrahedron 1992, 48, 3045−3060.

(13) Novel Synthesis of the Chiral Cyclic Dienediyne System Related to Neocarzinostatine Chromophore, Nakatani, K.; Arai, K.; Terashima, S. J. Chem. Soc., Chem. Commun. 1992, 289−291.

(12) Synthetic Studie on the Compounds Related to Neocarzinostatin Chromophore. 1. Synthesis of the Acyclic (E)- and (Z)-Dienediyne Systems, Nakatani, K.; Arai, K.; Hirayama, N.; Matsuda, F.; Terashima, S. Tetrahedron 1992, 48, 633−650.

1991

(11) Novel Synthesis of Three Types of C-Terminal Components of Renin Inhibitors from Unnatural (2S, 3S)-Tartalic Acid, Kobayashi, Y.; Matumoto, T.; Takemoto, Y.; Nakatani, K.; Ito, Y.; Terashima, S. Chem. Pharm. Bull. 1991, 39, 2550−2555.

(10) An Expeditious Synthesis of the Open-Chain (E)- and (Z)-Dienediyne Systems Related to Neocarzinostatine Chromophore, Nakatani, K.; Arai, K.; Yamada, K.; Terashima, S. Tetrahedron Lett. 1991, 32, 3405−3406.

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1990

(9) First Total Synthesis of dl-Duocarmycin, Fukuda, Y.; Nakatani, K.; Ito, Y.; Terashima, S. Tetrahedron Lett. 1990, 31, 6699−6702.

(8) Novel Synthesis of (2S, 3R, 4S)-4-Amino-5-cyclohexyl-1-morpholino-2,3-pentanediol and (2S, 3R,4S)-2-Amino-1-cyclohexyl-6-methyl-3,4-heptanediol, the C-Terminal Components of Renin Inhibitors, Kobayashi, Y.; Nakatani, K.; Ito, Y.; Terashima, S. Chem. Lett. 1990, 1709−1710.

(7) Synthesis and Cytotoxicity of the Acyclic (E)- and (Z)-Diendiyne Systems Related to Neocarzinostatine Chromophore, Nakatani, K.; Arai, K.; Hirayama, N.; Matsuda, F.; Terashima, S. Tetrahedron Lett. 1990, 31, 2323−2326.

1989

(6) Chiral Synthesis of the ABC-Ring System of Quinocarcin, Saito, S.; Tanaka, K.; Nakatani, K.; Matsuda, F.; Terashima, S. Tetrahedron Lett. 1989, 30, 7423−7426.

1988

(5) Regiocontrol by Electron Withdrawing Groups in the Rh-Catalyzed C-H Insertion of a-Diazoketones, Stork, G.; Nakatani, K. Tetrahedron Lett. 1988, 29, 2283−2286.

1987

(4) Novel Synthesis of (?)-Secologanin Aglucon-O-Silyl Ether from (+)-Genipin via Oxidative Fragmentation of g-Hydroxyalkylstannane, Isoe, S.; Katsumura, S.; Okada, T.; Yamamoto, K.; Takemoto, T.; Inaba, H.; Han, Q.; Nakatani, K. Tetrahedron Lett. 1987, 28, 5865−5868.

(3) Synthesis of 2-Indanones by Intramolecular Insertion of a-Diazoketones, Nakatani, K. Tetrahedron Lett. 1987, 28, 165−166.

1985

(2) Novel Synthesis of Brefeldin A. An application of the Oxidative Fragmentation of g-Hydroxyalkylstannanes, Nakatani, K.; Isoe, S. Tetrahedron Lett. 1985, 26, 2209−2212.

1984

(1) Oxidative Fragmentation of g-Hydroxyalkylstannanes. Stereospecific Formation of E and Z-Keto Olefins, Nakatani, K.; Isoe, S. Tetrahedron Lett. 1984, 25, 5335−5338.

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