JP
Lab Info

Division of Synthetic Chemistry for Molecular Systems (Yamaguchi Lab.)

# Synthetic Molecular Systems # Cell # Biomacromolecule # Biotechnology

With the advancement of data science, vast amounts of information related to life systems are utilized in life sciences, healthcare, and industry. In such a background, our laboratory is conducting studies with the aim of creating new molecular systems using organic synthetic chemistry to obtain previously unattainable unknown bio-information. We focus on the development of synthetic molecules with desired functionalities, engaging in research to efficiently produce, control, and visualize targeted biomolecules and cells. Our investigations also involve unraveling new molecular mechanisms for manipulating biomolecules and cells. The developed molecular systems serve as a platform technology addressing a wide range of challenges, from medical fields such as regenerative medicine, drug discovery, diagnostics, and drug delivery, to issues in the food and environmental sectors, including bioproduction and biosensors. Collaborating with researchers both domestically and internationally, we are actively engaged in applied research.

Staff

Satoshi Yamaguchi Professor
Research Map
Degree:
PhD (Engineering) (Mar. 2004, The University of Tokyo)
Career:
Jan. 2024 – present Professor, SANKEN, Osaka University
Apl. 2022 – Dec. 2023 Associate Professor, School of Engineering, The University of Tokyo
Oct. 2016 – Mar. 2020 PREST researcher, JST
Feb. 2013 – Mar. 2022 Lecturer (Aug. 2019-, Associate Professor), RCAST, The University of Tokyo
Apl. 2006 – Jan. 2013 Assistant Professor, School of Engineering, The University of Tokyo
Aug. 2005 – Mar. 2006 Postdoc, School of Engineering, Kyoto University
Apl. 2004 – July 2005 Postdoc, Institute of Advanced Materials Chemistry, Kyushu University
Shinobu Takizawa Associate Professor Research Map
Shinya Yamahira
Photopatterning Technology of Heterogeneous Cells Using a Photoactivatable Cell-Anchoring Surface and Single-Cell Interaction Assay of Heterogeneous Cell Pairs (Green: cancer cells, colorless: immune cells)
Light-responsive Conversion of Biomacromolecules and Cells Using Sterically Bulky caging, and Photocontrol of Intracellular Activity of Caged Toxic Proteins and Phagocytosis by Caged Immune Cells

Current Research Topics

  • Photoresponsive cell culture surfaces that can freely photo-control attachment of any types of cells
  • A high-throughput workflow for sorting cells based on single-cell images and conducting gene analysis.
  • Molecular systems that chemically convert any biomolecules or cells into stimulus-responsive ones 
  • Stimulus-responsive probes for selectively visualizing component molecules and cells in biological systems
  • Functional compounds and materials to facilitate the mass production of proteins and cells.
Lab Info

Division of Synthetic Chemistry for Molecular Systems (Yamaguchi Lab.)