JP
Lab Info

Department of Biomolecular Science and Reaction (Kuroda Lab.)

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# olfaction # signal transduction # enzyme # molecular interaction

Aim of Department of Biomolecular Science and Reaction is to understand various biological phenomena through revealing structures of biomolecules and interaction/reactions among them and to contribute to Bio-Industry by using technologies based on the mechanism of action. We are involved in the following projects. 1) An artificial olfactory sensor is successfully developed using about 400 of human olfactory receptors. We will specify a group of the olfactory receptors activated by a specific odor and construct database indicating the relations between odor-activated receptor group. Thereby, we aim to realize an odor information DX that "records, saves, transmits, and reconstructs" all odors in the near future. 2) As basic technology to elucidate atomic structures of the biomolecules, we participate in elucidating real structures of proteins through neutron crystallography of protein crystal and structural analysis with diffraction by X-ray free electron laser in addition to normal X-ray crystallography. 3) Furthermore, we develop novel antibiotics having antibacterial and anti-pathogenic effects against multidrug-resistant pathogenic bacteria.

Staff

Shun'ichi Kuroda ｜Professor
Research Map
Degree：
Ph.D.（Agriculture）（Nov., 1992; Kyoto University）
Career：

2019 - 2020

 Director, Artificial Intelligence Research Center, SANKEN, Osaka University

2017 - 2020

 Vice-Director, SANKEN, Osaka University

2015 - 

 Professor (Concurrent post), Graduate School of Science, Osaka University 

2015 -

 Professor (Concurrent post), the Graduate School of Frontier Biosciences、Osaka University 

2015 -

 Professor, SANKEN, Osaka University 

2009 - 2015

 Professor, Graduate School of Bioagricultural Sciences, Nagoya University

2002 - 2003

 Invited Professor, Medical School, Geneve University

1998 - 2009

 Associate Professor, SANKEN, Osaka University

1996 - 1998

 Associate Professor, Biosignal Research Center, Kobe University

1994 - 1996

 Assistant Professor, Biosignal Research Center, Kobe University

1986 - 1994

 Researcher, Biotechnology Laboratory, Takeda Chemical Industries Co. Ltd.

 

Toshihide Okajima Associate Professor Research Map
Yoh Wada Associate Professor Research Map
Kenji Tatematsu Assistant Professor Research Map
Masaharu Somiya Assistant Professor Research Map
We analyze intracellular signaling to odor using luminescence and fluorescence.
Neutron crystal structure of semiquinone radical intermediate of copper amine oxidase (left) and post translational modification complex for tryprophylquinone cofactor biogenesis (right)

Current Research Topics

  • Human Olfactory Receptor Sensor for Odor Reconstitution

Shun'ichi Kuroda, Yukiko Nakaya-Kishi, Kenji Tatematsu, Shuji Hinuma

Sensors; 2023年７月５日

 

  • Reporter gene assay for membrane fusion of extracellular vesicles.

Masaharu Somiya, Shun'ichi Kuroda

Journal of Extracellular Vesicles; 2021年11月10日

 

  • Neutron Crystallography of a Semiquinone Radical Intermediate of Copper Amine Oxidase Reveals a Substrate-Assisted Conformational Change of the Peptidyl Quinone Cofactor 

Takeshi Murakawa, Kazuo Kurihara, Mitsuo Shoji, Naomine Yano, Katsuhiro Kusaka, Yoshiaki Kawano, Mamoru Suzuki, Yasuteru Shigeta, Takato Yano, Motoyasu Adachi Katsuyuki Tanizawa, Toshihide Okajima

ACS Catalysis; 2023年9月7日

 

  • Functional and structural characterization of a flavoprotein monooxygenase essential for biogenesis of tryptophylquinone cofactor.

Toshinori Oozeki, Tadashi Nakai, Kazuki Kozakai, Kazuki Okamoto, Shun'ichi Kuroda, Kazuo Kobayashi, Katsuyuki Tanizawa, Toshihide Okajima

Nature Communication; 2021年２月10日

 

  • The a Subunit Isoforms of Vacuolar-type Proton ATPase Exhibit Differential Distribution in Mouse Perigastrulation Embryos. 

Ge-Hong Sun-Wada, Yoh Wada

Scientific Reports; 2022年8月10日

Lab Info

Department of Biomolecular Science and Reaction (Kuroda Lab.)

website