In the department of data-driven synthetic organic chemistry for medicinal and material applications, development of environmentally-friendly synthetic reaction processes that utilize infinite and inexhaustible solar energy, and electrical energy that can directly activate target molecules have been conducted. We are also studying data-driven domino synthesis, which actively uses machine learning to promote efficiency and acceleration of reactions. In recent, a highly atom-economical enantioselective organocatalyzed sequence has been established by using a flow reaction system. Suitable conditions were explored through reaction screening of multiple parameters using Gaussian process regression and Bayesian optimization with a small number of trial data. Our research goals are to save labor, improve productivity, and establish a direct molecular conversion process in fine chemical synthesis.
| Aug. 2024 - Present | Professor, SANKEN, Osaka University |
| 2009 - Jul. 2024 | Associate Professor, The Institute of Scientific and Industrial Research, Osaka University |
| 2007 - 2009 | Assistant Professor, The Institute of Scientific and Industrial Research, Osaka University |
| 2006 - 2008 | Research Associate (concurrent), Scripps Research |
| 2000 - 2007 | Assistant Professor, The Institute of Scientific and Industrial Research, Osaka University |
| 1999 - 2000 | JSPS Research Fellowship for Young Scientists |
Green and Efficient Protocols for the Synthesis of Sulfonyl Fluorides Using Potassium Fluoride as the Sole Fluorine Source
Sho Yamahara, Mohamed S. H. Salem, Takuma Kawai, Mai Watanabe, Yugo Sakamoto, Tomohide Okada, Yoshikazu Kimura, Shinobu Takizawa, Masayuki Kirihara
ACS Sustainable Chemistry & Engineering July 16, 2024
In-silico-assisted Derivatization of Triarylboranes for the Catalytic Reductive Functionalization of Aniline-derived Amino Acids and Peptides with H2
Yusei Hisata, Takashi Washio, Shinobu Takizawa, Sensuke Ogoshi, Yoichi Hoshimoto
Nature Communications 07 May 2024
Light-induced Autoxidation of Aldehydes to Peracids and Carboxylic Acids
Mohamed S. H. Salem, Carla Dubois, Yuya Takamura, Atsuhito Kitajima, Takuma Kawai, Shinobu Takizawa, Masayuki Kirihara
Green Chemistry 29th November 2023
Atroposelective Synthesis of C–C Axially Chiral Compounds via Mono- and Dinuclear Vanadium Catalysis
Ankit Kumar, Hiroaki, Sasai, Shinobu Takizawa
Accounts of Chemical Research October 7, 2022
Energy-, Time-, and Labor-saving Synthesis of α-Ketiminophosphonates: Machine-learning-assisted Simultaneous Multiparameter Screening for Electrochemical Oxidation
Masaru Kondo, Akimasa Sugizaki, Md. Imrul Khalid, H. D. P. Wathsala, Kazunori Ishikawa, Satoshi Hara, Takayuki Takaai, Takashi Washio, Shinobu Takizawa, Hiroaki Sasai
Green Chemistry 30th June 2021
