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  4. 鈴木 孝禎 Takayoshi SUZUKI

鈴木 孝禎 Takayoshi SUZUKI

経歴

大阪大学　産業科学研究所　教授
博士（薬学）

1995年3月 東京大学薬学部薬学科卒業
1997年3月 東京大学大学院薬学系研究科 薬学専攻修士課程修了
1997年4月 (株）日本たばこ産業　入社
2003年1月 名古屋市立大学大学院薬学研究科　助手
2005年7月 博士（薬学）取得（東京大学大学院薬学系研究科）
2007年4月 名古屋市立大学大学院薬学研究科　助教
2007年4月 米国スクリプス研究所　客員研究員
2009年4月 名古屋市立大学大学院薬学研究科　講師
2009年10月 科学技術振興機構さきがけ　研究者（兼任）
2011年9月 京都府立医科大学大学院医学研究科　教授
2014年10月 科学技術振興機構CREST 研究代表者
2019年6月 大阪大学産業科学研究所　教授
2019年6月 京都府立医科大学大学院医学研究科　客員教授
現在に至る

受賞

平成17年度　日本薬学会薬学研究ビジョン部会賞
Bioorganic & Medicinal Chemistry Letters Most Cited Paper 2005-2008 Award
平成21年度　日本薬学会奨励賞
Bioorganic & Medicinal Chemistry Letters Most Cited Paper 2006-2009 Award
平成21年度　日本薬学会メディシナルケミストリーシンポジウム優秀賞
2009年度　有機合成化学協会大正製薬研究企画賞
平成23年度　科学技術分野の文部科学大臣表彰若手科学者賞
平成24年度　長瀬研究振興賞
平成27年度　日本薬学会メディシナルケミストリーシンポジウム優秀賞

委員

2008　次世代を担う有機化学シンポジウム世話人（~2013年）
2014　次世代を担う有機化学シンポジウムアドバイザー
2011　ファルマシアトピックス専門小委員（~2014年）
2016　日本ケミカルバイオロジー学会世話人
2016　京都生体質量分析研究会世話人
2017　Editorial Advisory Board, Journal of Medicinal Chemistry (American Chemical Society)
2018　創薬ニューフロンティア検討会メンバー
2019　Editor, Chemical and Pharmaceutical Bulletin (The Pharmaceutical Society of Japan)
2021　Associate Editor, Journal of Medicinal Chemistry (American Chemical Society)
2021　日本薬学会医薬化学部会常任世話人
2023　日本エピジェネティクス研究会幹事
2024　Ewha Global Fellow of the Ewha Womans University
2024　Editor-in-Chief, Chemical and Pharmaceutical Bulletin (The Pharmaceutical Society of Japan)

  1. “Role of plant homeodomain finger protein 8 regulates cell proliferation via the MEK/ERK pathway in P19 embryonic carcinoma cells” Shusuke Doi, Takayoshi Suzuki, Shuhei Soeda, Naoki Miyata, Tetsuya Inazu. Biochem. Biophys. Rep. 2024, 38, 101670.
  2. “Epigenetic Inhibitors as Alzheimer’s Disease Therapeutic Agents” Yasunobu Yamashita, Yukihiro Itoh, Yuri Takada, Takayoshi Suzuki. Chem. Pharm. Bull. 2024, 72, in press.
  3. “Identification of Proteolysis Targeting Chimeras (PROTACs) for Lysine Demethylase 5 and their Neurite Outgrowth-Promoting Activity” Tetsuya Iida, Yukihiro Itoh, Yukari Takahashi, Yuka Miyake, Farzad Zamani, Yasunobu Yamashita, Yuri Takada, Toshiki Akiyama, Jun Ibaraki, Kyoka Okuda, Yuto Tokuda, Tomoka Nishimura, Koto Hidaka, Hiiro Mori, Makoto Oba, Takayoshi Suzuki. Chem. Pharm. Bull. 2024, 72, in press.
  4. “General Synthesis of meso-1,4-Dialdehydes and their Application in Ir-Catalyzed Asymmetric Tishchenko Reactions” Runze Zhao, Ismiyarto, Da-Yang Zhou, Kaori Asano, Takayoshi Suzuki, Hiroaki Sasai, and Takeyuki Suzuki. ACS Omega 2024, 9, in press.
  5. “Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells” Yosuke Ota, Yukihiro Itoh, Yuri Takada, Yasunobu Yamashita, Chenliang Hu, Mano Horinaka, Yoshihiro Sowa, Mitsuharu Masuda, Toshiyuki Sakai, Takayoshi Suzuki. Bioorg. Med. Chem. 2024, 100, 1117632.
  6. “The impact of selective HDAC inhibitors on the transcriptome of early mouse embryos” Ruiqi Shao, Takayoshi Suzuki, Mikita Suyama, Yuichi Tsukada. BMC Genomics 2024, 25, 143.
  7. “Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity” Mitsuhiro Terao, Yasunobu Yamashita, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki. Bioorg. Med. Chem. 2024, 98, 117579.
  8. “Identification of a Histone Deacetylase 8 Inhibitor Through Drug Screenings Based on Machine Learning” Atika Nurani, Yasunobu Yamashita, Yuuki Taki, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki. Chem. Pharm. Bull. 2024, 72, 173–178.
  9. “A Structure-Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 1” Yuri Takada, Kyohei Adachi, Yuka Fujinaga, Yasunobu Yamashita, Yukihiro Itoh, Takayoshi Suzuki. Chem. Pharm. Bull. 2024, 72, 155–160.
  10. “Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice” Haiyan Li, Ayako Kawatake-Kuno, Hiromichi Inaba, Yuka Miyake, Yukihiro Itoh, Takatoshi Ueki, Naoya Oishi, Toshiya Murai, Takayoshi Suzuki, Shusaku Uchida. Neuron 2024, 112, 786-804.e8.
  11. “Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation” Yukihiro Itoh, Peng Zhan, Toshifumi Tojo, Pattaporn Jaikhan, Yosuke Ota, Miki Suzuki, Ying Li, Zi Hui, Yukiko Moriyama, Yuri Takada, Yasunobu Yamashita, Makoto Oba, Shusaku Uchida, Mitsuharu Masuda, Shinji Ito, Yoshihiro Sowa, Toshiyuki Sakai, Takayoshi Suzuki. J. Med. Chem. 2023, 66, 15171–15188..
  12. “Pharmacological inhibition of KDM1A/LSD1 enhances estrogen receptor beta-mediated tumor suppression in ovarian cancer” Prabhakar Pitta Venkata, Sridharan Jayamohan, Yi He, Salvador Alejo, Jessica D. Johnson, Bridgitte E. Palacios, Uday P. Pratap, Yihong Chen, Zexuan Liu, Yi Zou, Lai Zhao, Takayoshi Suzuki, Suryavathi Viswanadhapalli, Susan T. Weintraub, Srinath Palakurthi, Philip T. Valente, Rajeshwar R. Tekmal, Edward Kost, Ratna K. Vadlamudi, Gangadhara R. Sareddy. Cancer Lett. 2023, 575, 216383.
  13. “SIRT2 Inhibition Rescues Neurodegenerative Pathology but Increases Systemic Inflammation in a Transgenic Mouse Model of Alzheimer’s Disease” Noemi Sola-Sevilla, Alberto Mesa-Lombardo, Mikel Aleixo, Sara Exposito, Teresa Diaz-Perdigón, Amaya Azqueta, Farzad Zamani, Takayoshi Suzuki, Silvia Maioli, Francesca Eroli, Anna Matton, Maria J. Ramı́rez, Maite Solas, Rosa M. Tordera, Eduardo D. Martı́n, Elena Puerta. J. Neuroimmune Pharmacol. 2023, 18, 529–550.
  14. “Origin of the kinetic HDAC2-selectivity of an HDAC inhibitor” Hirokazu Mishima, Yukihiro Itoh, Takashi Kurohara, Takayoshi Suzuki, Naoya Asada, Ken-ichi Kusakabe, Yuko Okamoto. J. Comput. Chem. 2023, 44, 1604–1609.
  15. “Catalytic asymmetric synthesis of (‒)-arctigenin using a chiral Ir complex” Rui Jiang, Da-Yang Zhou, Kaori Asano, Takayoshi Suzuki, Takeyuki Suzuki. Tetrahedron 2023, 133, 133287.
  16. “Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double strand break repair and augments efficacy of temozolomide in glioblastoma” Salvador Alejo, Bridgitte E. Palacios, Prabhakar Pitta Venkata, Yi He, Wenjing Li, Jessica D. Johnson, Yihong Chen, Uday P. Pratap, Sridharan Jayamohan, Kyra Clarke, Yi Zou, Yingli Lv, Korri Weldon, Suryavathi Viswanadhapalli, Zhao Lai, Zhenqing Ye, Yidong Chen, Andrea R. Gilbert, Takayoshi Suzuki, Rajeshwar R. Tekmal, Weixing Zhao, Siyuan Zheng, Ratna K. Vadlamudi, Andrew J. Brenner, Gangadhara R. Sareddy. Neuro Oncol. 2023, 25, 1249–1261.
  17. “The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamide as AMPD2 inhibitors with a novel mechanism of action” Yuki Kitao, Tadataka Saito, Satoshi Watanabe, Yasuhiro Oe, Koichi Takahashi, Tatsuo Akaki, Tsuyoshi Adachi, Satoki Doi, Kenji Yamanaka, Yasutaka Murai, Makoto Oba, Takayoshi Suzuki. Bioorg. Med. Chem. Lett. 2023, 80, 129110.
  18. “Cancer-Cell-Selective Targeting by Arylcyclopropylamine-Vorinostat Conjugates” Yosuke Ota, Yukihiro Itoh, Takashi Kurohara, Ritesh Singh, Elghareeb E. Elboray, Chenliang Hu, Farzad Zamani, Anirban Mukherjee, Yuri Takada, Yasunobu Yamashita, Mie Morita, Mano Horinaka, Yoshihiro Sowa, Mitsuharu Masuda, Toshiyuki Sakai, Takayoshi Suzuki. ACS Med. Chem. Lett. 2022, 13, 1568–1573.
  19. “A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production” Wei Zhe, Naomi Hoshina, Yukihiro Itoh, Toshifumi Tojo, Takayoshi Suzuki, Koji Hase, Daisuke Takahashi. Biol. Pharm. Bull. 2022, 45, 1364–1372.
  20. “Medicinal Chemistry Research on Targeting Epigenetic Complexes” Yuri Takada, Yasunobu Yamashita, Yukihiro Itoh Takayoshi Suzuki. J. Synth. Org. Chem. Jpn. 2022, 80, 664-675.
  21. “Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC)” Jiranan Chotitumnavee, Yasunobu Yamashita, Yukari Takahashi, Yuri Takada, Tetsuya Iida, Makoto Oba, Yukihiro Itoh, Takayoshi Suzuki. Chem. Commun. 2022, 58, 4635-4638. 
  22. “Utilization of α and β Epimerization for Synthesis of Both Enantiomers of Enterolactone” Rui Jiang, Ismiyarto, Tsukasa Abe, Da-Yang Zhou, Kaori Asano, Takayoshi Suzuki, Hiroaki Sasai, Takeyuki Suzuki. J. Org. Chem. 2022, 87, 5051-5056.
  23. “Novel Histone Modifications in Microglia Derived from a Mouse Model of Chronic Pain” Ping Zhang, Jennifer Guergues, Amy R. Alleyne, Thomas J. Cirino, Owen Nadeau, Ariana M. Figueroa, Heather M. Stacy, Takayoshi Suzuki, Jay P. McLaughlin, Stanley M. Stevens, Jr., Bin Liu. Proteomics 2022, 22, e2100137.
  24. “KDM1A inhibition augments the efficacy of rapamycin for the treatment of endometrial cancer” Prabhakar Pitta Venkata, Yihong Chen, Salvador Alejo, Yi He, Bridgitte E. Palacios, Ilanna Loeffel, Junhao Liu, Uday P. Pratap, Gabrielle Gray, Sureshkumar Mulampurath Achuthan Pillai, Yi Zou, Zhao Lai, Takayoshi Suzuki, Suryavathi Viswanadhapalli, Srinath Palakurthi, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Edward Kost, Gangadhara R. Sareddy. Cancer Lett. 2022, 524, 219-231.
  25. “Identification of novel histone deacetylase 6-selective inhibitors bearing 3,3,3-trifluorolactic amide (TFLAM) motif as a zinc binding group” Takashi Kurohara, Keita Tanaka, Daisuke Takahashi, Satoshi Ueda, Yasunobu Yamashita, Yuri Takada, Hirokazu Takeshima, Shengwang Yu, Yukihiro Itoh, Koji Hase, Takayoshi Suzuki. ChemBioChem 2021, 22, 3158-3163.
  26. “Identification of Potent and Selective Inhibitors of Fat Mass Obesity Associated Protein Using a Fragment-Merging Approach” Muthuraj Prakash, Yukihiro Itoh, Yoshie Fujiwara,Yukari Takahashi, Yuri Takada, Paolo Mellini, Elghareeb E. Elboray, Mitsuhiro Terao, Yasunobu Yamashita, Chika Yamamoto, Takao Yamaguchi, Masayuki Kotoku, Yuki Kitao, Ritesh Singh, Rohini Roy, Satoshi Obika, Makoto Oba, Dan Ohtan Wang, and Takayoshi Suzuki. J. Med. Chem. 2021, 64, 15810–15824.
  27. “Ca2+-activated K+ channel KCa1.1 as a therapeutic target to overcome chemoresistance in three-dimensional sarcoma spheroid models” Susumu Ohya, Junko Kajikuri, Kyoko Endo, Hiroaki Kito, Elghareeb Elboray, Takayoshi Suzuki. Cancer Sci. 2021, 112, 3769-3783.
  28. “Catalytic Enantioselective Tishchenko Reaction of meso-Dialdehyde: Catalytic Asymmetric Synthesis of Cedarmycins” Ismiyarto, Nobuki Kishi, Yuki Adachi, Rui Jiang, Takahiro Doi, Da-Yang Zhou, Kaori Asano, Yasushi Obora, Takayoshi Suzuki, Hiroaki Sasai, and Takeyuki Suzuki. RSC Adv. 2021, 11, 11606–11609.
  29. “Discovery of novel tetrahydrobenzo[b]thiophene-3-carbonitriles as histone deacetylase inhibitors” Piyush Gediya, Vivek K. Vyas, Vincenzo Carafa, Nikum Sitwala, Laura Della Torre, Angelita Poziello, Takashi Kurohara, Takayoshi Suzuki, Varalakshmi Raghuraman, K. Suthindhiran, Debarpan Ghosh, Dhiraj Bhatia, Lucia Altucci, Manjunath D. Ghate. Bioorg. Chem. 2021, 110, 104801.
  30. “Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5C Degraders” Tetsuya Iida, Yukihiro Itoh, Yukari Takahashi, Yasunobu Yamashita,　Takashi Kurohara,　Yuka Miyake, Makoto Oba, Takayoshi Suzuki. ChemMedChem 2021, 16, 1609-1618.
  31. “N+-C-H···O Hydrogen bonds in protein-ligand complexes and their application to drug design” Yukihiro Itoh, Takashi Kurohara, Takayoshi Suzuki. J. Synth. Org. Chem. Jpn. 2020, 78, 1151–1162.
  32. “KDM1A inhibition is effective in reducing stemness and treating triple negative breast cancer” Mei Zhou, Prabhakar Pitta Venkat, Suryavathi Viswanadhapalli, Bridgitte Palacios, Salvador Alejo, Yihong Chen, Yi He, Uday Pratap, Yi Zou, Zhao Lai, Takayoshi Suzuki, Andrew Brenner, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Gangadhara R. Sareddy. Breast Cancer Res. Treat. 2021, 185, 343–357.
  33. “Selective lysine specific demethylase 1 inhibitor, NCL1, could cause testicular toxicity via the regulation of apoptosis” Satoshi Nozaki, Taku Naiki, Aya Naiki-Ito, Shoichiro Iwatsuki, Tomoki Takeda, Toshiki Etani, Takashi Nagai, Keitaro Iida, Takayoshi Suzuki, Satoru Takahashi, Takahiro Yasui, Yukihiro Umemoto. Andrology 2020, 8, 1895–1906.
  34. “Cross-Species Chromatin Interactomes Drive Heterochromatin, Enhancer, and Transcriptional Rewiring in Epstein-Barr Virus Positive Gastric Adenocarcinoma” Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Manjie Xing, Xuewen Ong, Takayuki Hoshii, Genki Usui, Motoaki Seki, Yasunobu Mano, Bahityar Rahmutulla, Teru Kanda, Takayoshi Suzuki, Sun Young Rha, Tetsuo Ushiku, Masashi Fukayama, Patrick Tan, Atsushi Kaneda. Nat. Genet. 2020, 52, 919–930.
  35. “Downregulation of the Ca2+-activated K+ channel KCa3.1 in mouse preosteoblast cells treated with vitamin D receptor agonist” Hiroaki Kito, Haruka Morihiro, Yuka Sakakibara, Kyoko Endo, Junko Kajikuri, Takayoshi Suzuki, Susumu Ohya. Am. J. Physiol. Cell Physiol. 2020, 319, C345–C358.
  36. “Metalloprotein-Catalyzed Click Reaction for In Situ Generation of a Potent Inhibitor” Yuka Miyake, Yukihiro Itoh, Yoshinori Suzuma, Hidehiko Kodama, Takashi Kurohara, Yasunobu Yamashita, Remy Narozny, Yutaro Hanatani, Shusaku Uchida, Takayoshi Suzuki. ACS Catal. 2020, 10, 5383–5392.
  37. “Possible contribution of inflammation-associated hypoxia to increased K2P1 K+ channel expression in CD4+ T cells of the mouse model for inflammatory bowel disease” Kyoko Endo, Hiroaki Kito, Ryo Tanaka, Junko Kajikuri, Satoshi Tanaka, Elghareeb E. Elboray, Takayoshi Suzuki, Susumu Ohya. Int. J. Mol. Sci. 2020, 21, 38.
  38. “A metabolic pathway-oriented screening targeting S-adenosyl-l-methionine reveals the epigenetic remodeling activities of naturally occurring catechols” Shusuke Ogihara, Toru Komatsu, Yukihiro Itoh, Yuka Miyake, Takayoshi Suzuki, Kouichi Yanagi, Yusuke Kimura, Tasuku Ueno, Kenjiro Hanaoka, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Yasuteru Urano. J. Am. Chem. Soc. 2020, 142, 21–26.
  39. “LSD1-mediated repression of GFI1 super-enhancer plays an essential role in erythroleukemia” Goichi Tatsumi, Masahiro Kawahara, Ryusuke Yamamoto, Masakatsu Hishizawa, Katsuyuki Kito, Takayoshi Suzuki, Akifumi Takaori-Kondo, Akira Andoh. Leukemia 2020, 34, 746–758.
  40. “Discovery of gamma-mangostin from Garcinia mangostana as potent and selective natural SIRT2 inhibitor” Keng Yoon Yeong, Kooi Yeong Khaw, Yukari Takahashi, Yukihiro Itoh, Vikneswaran Murugaiyah, Takayoshi Suzuki. Bioorg. Chem. 2020, 94, 103403.
  41. “Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence accelerated mouse model”　Teresa Diaz-Perdigon, Borja Belloch, Ana Ricobaraza, Elghareeb Elboray, Takayoshi Suzuki, Rosa Tordera, Elena Puerta. Neuropsychopharmacolgy 2020, 45, 347–357.
  42. “Genome-wide ChIP-seq data with a transcriptome analysis reveals the groups of genes regulated by histone demethylase LSD1 inhibition in esophageal squamous cell carcinoma cells” Isamu Hoshino, Masahiko Takahashi, Yasunori Akutsu, Kentaro Murakami, Yasunori Matsumoto, Hiroshi Suito, Nobufumi Sekino, Aki Komatsu, Keiko Iida, Takayoshi Suzuki, Itsuro Inoue, Fumitaka Ishige, Yosuke Iwatate, Hisahiro Matsubara. Oncol. Lett. 2019 18, 872–881.
  43. “Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the “Selectivity Pocket”, Substrate-Binding Site, and NAD+-Binding Site” Paolo Mellini, Yukihiro Itoh, Elghareeb E. Elboray, Hiroki Tsumoto, Ying Li, Miki Suzuki, Yukari Takahashi, Toshifumi Tojo, Takashi Kurohara, Yuka Miyake, Yuri Miura, Yuki Kitao, Masayuki Kotoku, Tetsuya Iida, Takayoshi Suzuki. J. Med. Chem. 2019, 62, 5844–5862.
  44. “Identification of ortho-hydroxy anilide as a novel scaffold for lysine demethylase 5 inhibitors” Pattaporn Jaikhan, Benjaporn Buranrata, Yukihiro Itoh, Jiranan Chotitumnavee, Takashi Kurohara, Takayoshi Suzuki, Bioorg. Med. Chem. Lett. 2019, 29, 1173–1176.
  45. “NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses castration-resistant prostate cancer growth via regulation of apoptosis and autophagy” Toshiki Etani, Taku Naiki, Aya Naiki-Ito, Takayoshi Suzuki, Keitaro Iida, Satoshi Nozaki, Hiroyuki Kato, Yuko Nagayasu, Shugo Suzuki, Noriyasu Kawai, Takahiro Yasui, Satoru Takahashi. J. Clin. Med.2019, 8, 442.
  46. “Discovery of the Second Generation RORg Inhibitors Composed of an Azole Scaffold” Masayuki Kotoku, Takaki Maeba, Shingo Fujioka, Masahiro Yokota, Noriyoshi Seki, Keisuke Ito, Yoshihiro Suwa, Taku Ikenogami, Kazuyuki Hirata, Yasunori Hase, Yoshiaki Katsuda, Naoki Miyagawa, Kojo Arita, Kota Asahina, Masato Noguchi, Akihiro Nomura, Satoki Doi, Tsuyoshi Adachi, Paul Crowe, Haiyan Tao, Scott Thacher, Hiromasa Hashimoto, Takayoshi Suzuki, Makoto Shiozaki. J. Med. Chem. 2019, 62, 2837–2842.
  47. “Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy” Yuka Miyake, Yukihiro Itoh, Atsushi Hatanaka, Yoshinori Suzuma, Miki Suzuki, Hidehiko Kodama, Yoshinobu Arai, Takayoshi Suzuki. Bioorg. Med. Chem. 2019, 27, 1119–1129.
  48. “N+-C-H···O Hydrogen bonds in protein-ligand complexes” Yukihiro Itoh, Yusuke Nakashima, Shuichiro Tsukamoto, Takashi Kurohara, Miki Suzuki, Yoshitake Sakae, Masayuki Oda, Yuko Okamoto, Takayoshi Suzuki. Sci. Rep. 2019, 9, 767.
  49. “HDAC8 inhibition ameliorates pulmonary fibrosis” Shigeki Saito, Yan Zhuang, Takayoshi Suzuki, Yosuke Ota, Marjorie Bateman, Ala Alkhatib, Gilbert Morris, Joseph Lasky. Am. J. Physiol. Lung Cell. Mol. Physiol. 2019, 316, L175–L186.
  50. “Synthesis of LSD1 Inhibitor–Pyrrole Imidazole Polyamide Conjugates for Region-Specific Alterations of Histone Modification” Rui Qin, Shihori Takayanagi, Yusuke Kondo, Jiawei Li, Naoki Shiga, Masaya Nakajima, Ken-ichi Shinohara, Natsumi Yoda, Takayoshi Suzuki, Atsushi Kaneda, Tetsuhiro Nemoto. Heterocycles 2019, 99, 891–
  51. “Design, synthesis, and biological evaluation of a conjugate of 5-fluorouracil and an LSD1 inhibitor” Yosuke Ota, Arisa Nakamura, Elghareeb E. Elboray, Yukihiro Itoh, Takayoshi Suzuki. Chem. Pharm. Bull. 2019, 66, 192–195.
  52. “Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants” Martin Marek, Tajith Baba Shaik, Tino Heimburg, Alokta Chakrabarti, Julien Lancelot, Elizabeth Ramos Morales, Cyrielle Da Veiga, Dmitrii V. Kalinin, Jelena Melesina, Dina Robaa, Karin Schmidtkunz, Takayoshi Suzuki, Ralph Holl, Eric Ennifar, Raymond Pierce, Manfred Jung, Wolfgang Sippl, Christophe Romier. J. Med. Chem. 2018, 61, 10000–10016.
  53. Histone deacetylases enhance Ca2+-activated K+ channel KCa3.1 expression in murine inflammatory CD4+ T cells. Miki Matsui, Kyoko Terasawa, Hiroaki Kito, Kyoko Endo, Junko Kajikuri, Pattaporn Jaikhan, Takayoshi Suzuki, Susumu Ohya. J. Mol. Sci. 2018, 19, 2942.
  54. “Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines” Tomohiro Kozako, Mellini Paolo, Takeo Ohsugi, Akiyoshi Aikawa, Yu-ichiro Uchida, Shin-ichiro Honda, Takayoshi Suzuki. BMC Cancer 2018, 18, 791.
  55. “Region-specific alteration of histone modification by LSD1 inhibitor conjugated with pyrrole-imidazole polyamide” Kokiladevi Alagarswamy, Ken-ichi Shinohara, Shihori Takayanagi, Masaki Fukuyo, Atsushi Okabe, Bahityar Rahmutulla, Natsumi Yoda, Rui Qin, Naoki Shiga, Kazuko Kita, Takayoshi Suzuki, Tetsuhiro Nemoto, Atsushi Kaneda. Oncotarget 2018, 9, 29316–29335.
  56. “Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures” Yosuke Ota, Taeko Kakizawa, Yukihiro Itoh, Takayoshi Suzuki. Molecules 2018, 23, 1099.
  57. “Computational Analysis for Selectivity of Histone Deacetylase Inhibitor by Replica-Exchange Umbrella Sampling Molecular Dynamics Simulations” Shuichiro Tsukamoto, Yoshitake Sakae, Yukihiro Itoh, Takayoshi Suzuki, Yuko Okamoto. J. Chem. Phys. 2018, 148, 125102.
  58. “Selective dissociation between LSD1 and GFI1B by a LSD1 inhibitor NCD38 induces the activation of ERG super-enhancer in erythroleukemia cells” Ryusuke Yamamoto, Masahiro Kawahara, Shinji Ito, Junko Satoh, Goichi Tatsumi, Masakatsu Hishizawa, Takayoshi Suzuki, Akira Andoh. Oncotarget 2018, 9, 21007–21021.
  59. “HDAC8 regulates neural differentiation through embryoid body formation in P19 cells” Syouichi Katayama, Atsushi Morii, Juliet O. Makanga, Takayoshi Suzuki, Naoki Miyata, Tetsuya Inazu. BioChem. Biophys. Res. Commun. 2018, 498, 45–51.
  60. “Design, synthesis and evaluation of g-turn mimetics as LSD1-selective inhibitors” Yosuke Ota, Shin Miyamura, Misaho Araki, Yukihiro Itoh, Shusuke Yasuda, Mitsuharu Masuda, Tomoyuki Taniguchi, Yoshihiro Sowa, Toshiyuki Sakai, Kenichiro Itami, Junichiro Yamaguchi, Takayoshi Suzuki. Bioorg. Med. Chem. 2018, 26, 775–785.
  61. “Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors” Taeko Kakizawa, Yosuke Ota, Yukihiro Itoh, Takayoshi Suzuki. Bioorg. Med. Chem. Lett. 2018, 28, 167–169.
  62. “Potent Mechanism-Based Sirtuin-2-Selective Inhibition by an In-Situ-Generated Occupant of the Substrate-Binding Site, “Selectivity Pocket” and NAD+-Binding Site” Paolo Mellini, Yukihiro Itoh, Hiroki Tsumoto, Ying Li, Miki Suzuki, Natsuko Tokuda, Taeko Kakizawa, Yuri Miura, Jun Takeuchi, Maija Lahtela-Kakkonen, Takayoshi Suzuki. Chem. Sci. 2017, 7, 6400–6408.
  63. “A novel LSD1 inhibitor NCD38 ameliorates MDS-related leukemia with complex karyotype by attenuating leukemia programs via activating super-enhancers” Noriko Sugino, Masahiro Kawahara, Goichi Tatsumi, Akinori Kanai, Hirotaka Matsui, Ryusuke Yamamoto, Yuya Nagai, Sumie Fujii, Yayoi Shimazu, Masakatsu Hishizawa, Toshiya Inaba, Akira Andoh, Takayoshi Suzuki, Akifumi Takaori-Kondo. Leukemia 2017, 31, 2303–2314.
  64. “SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action” Mercedes Erburu, Irene Muñoz-Cobo, Teresa Díaz, Paolo Mellini, Takayoshi Suzuki, Elena Puerta, Rosa M. Tordera. Neuropharmacology 2017, 117, 195–208.
  65. “CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the Fgf1 Gene” Shusaku Uchida, Brett J.W. Teubner, Charles Hevi, Kumiko Hara, Ayumi Kobayashi, Rutu M. Dave, Tatsushi Shintaku, Pattaporn Jaikhan, Hirotaka Yamagata, Takayoshi Suzuki, Yoshifumi Watanabe, Stanislav S. Zakharenko, Gleb P. Shumyatsky. Cell Rep. 2017, 18, 352–366.
  66. “Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response (UPR) pathway”Gangadhara Reddy Sareddy, Suryavathi Viswanadhapalli, Prathibha Surapaneni, Takayoshi Suzuki, Andrew Brenner, Ratna Vadlamudi. Oncogene 2017, 36, 2423–2434.
  67. “Transcriptional repression of HER2 by ANO1 Cl– channel inhibition in human breast cancer cells with resistance to trastuzumab” Mayu Fujimoto, Takahiro Inoue, Hiroaki Kito, Satomi Niwa, Takayoshi Suzuki, Katsuhiko Muraki,Susumu Ohya. BioChem. Biophys. Res. Commun. 2017, 482, 188–194.
  68. “Down-regulation of the Ca2+-activated K+ channel KCa1.1 in human breast cancer cells treated with vitamin D receptor agonists” Anowara Khatun, Mayu Fujimoto, Satomi Niwa, Hiroaki Kito, Takayoshi Suzuki, Susumu Ohya. Int. J. Mol. Sci. 2016, 17, 2083.
  69. “Targeting Cancer with PCPA-Drug Conjugates: LSD1 Inhibition-Triggered Release of 4-Hydroxytamoxifen” Yosuke Ota, Yukihiro Itoh, Asako Kaise, Kiminori Ohta, Yasuyuki Endo, Mitsuharu Masuda, Yoshihiro Sowa, Toshiyuki Sakai, Takayoshi Suzuki. Angew. Chem. Int. Ed. 2016, 55, 16115–16118.
  70. “C-H Activation Enables Rapid Structure-Activity Relationship Study of Arylcylclopropyl Amines for Potent and Selective LSD1 Inhibitors” Shin Miyamura, Misaho Araki, Yosuke Ota, Yukihiro Itoh, Shusuke Yasuda, Mitsuharu Masuda, Tomoyuki Taniguchi, Yoshihiro Sowa, Toshiyuki Sakai, Takayoshi Suzuki, Kenichiro Itami, Junichiro Yamaguchi. Org. Biomol. Chem. 2016, 14, 8576–8585.
  71. “Hippocampal microRNA-124 enhances chronic stress resilience in mice” Fumihiro Higuchi, Shusaku Uchida, Hirotaka Yamagata, Naoko Abe-Higuchi, Teruyuki Hobara, Kumiko Hara, Ayumi Kobayashi, Tatsushi Shintaku, Yukihiro Itoh, Takayoshi Suzuki, Yoshifumi Watanabe. J. Neurosci.2016, 36, 7253–7267.
  72. “False HDAC inhibition by aurone compound” Yukihiro Itoh, Miki Suzuki, Taiji Matsui, Yosuke Ota, Zi Hui, Kazunori Tsubaki, Takayoshi Suzuki. Chem. Pharm. Bull. 2016, 64, 1124–1128.
  73. “A Drosophila model for screening anti-obesity agents” Men Tran Thanh, Thanh Duong Ngoc Van, Masamitsu Yamaguchi, Takayoshi Suzuki, Gen Hattori, Masayuki Arii, Nguyen Tien Huy, Kaeko BioMed Res. Int. 2016, 2016:6293163.
  74. “Discovery of KDM5A Inhibitors: Homology Modeling, Virtual Screening and Structure-Activity Relationship Analysis” Xiaoai Wu, Zhen Fang, Bo Yang, Lei Zhong, Qiuyuan Yang, Chunhui Zhang, Shenzhen Huang, Rong Xiang, Takayoshi Suzuki, Lin-Li Li, Sheng-Yong Yang. Bioorg. Med. Chem. Lett. 2016, 26, 2284–2288.
  75. “Downregulation of the Ca2+-activated K+ channel KCa1 by histone deacetylase inhibition in human breast cancer cells” Saki Kanatsuka, Noriyuki Hatano, Sayo Matsuba, Mayu Fujimoto, Satomi Niwa, Hiroaki Kito, Peng Zhan, Takayoshi Suzuki, Katsuhiko Muraki, Susumu Ohya. Pharmacol. Res. Perspect. 2016, 4, e00228.
  76. “Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide” Taeko Kakizawa, Tamio Mizukami, Yukihiro Itoh, Makoto Hasegawa, Ryuzo Sasaki, Takayoshi Suzuki. Bioorg. Med. Chem. Lett. 2016, 26, 1193–1195.
  77. “Identification of SNAIL1 Peptide-Based Irreversible Lysine Specific Demethylase 1-Selective Inactivators” Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka, Takayoshi Suzuki. J.  Med. Chem. 2016, 59, 1531–1544.
  78. “HistoneDemethylase LSD1 Inhibitors Prevent Cell Growth by Regulating Gene Expression in Esophageal Squamous Cell Carcinoma Cells” Isamu Hoshino, Yasunori Akutsu, Kentaro Murakami, Naoki Akanuma, Yuka Isozaki, Tetsuro Maruyama, Takeshi Toyozumi, Yasunori Matsumoto, Hiroshi Suito, Masahiko Takahashi, Nobufumi Sekino, Aki Komatsu, Takayoshi Suzuki, Hisahiro Matsubara. Ann.  Surg. Oncol. 2016, 23, 312–320.
  79. “Peptidyl prolyl isomerase Pin1-inhibitory activity of d-glutamic and d-aspartic acid derivatives bearing a cyclic aliphatic amine moiety” Hidehiko Nakagawa, Suguru Seike, Masatoshi Sugimoto, Naoya Ieda, Mitsuyasu Kawaguchi, Takayoshi Suzuki, Naoki Miyata.  Bioorg. Med. Chem. Lett. 2015, 25, 5619–5624.
  80. “Chronic stress and antidepressant induced changes inHdac5 and Sirt2 affect synaptic plasticity” Erburu M., Muñoz-Cobo I., Domínguez J., Beltran E., Suzuki T., Mai A., Valente S., Puerta E., Tordera R. M. Eur. Neuropsychopharmacol. 2015, 25, 2036–2048.
  81. “Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer” Qin Ye, Andreana Holowatyj, Jack Wu, Hui Liu, Lihong Zhang, Takayoshi Suzuki, Zeng-Quan Yang. Am. J. Cancer Res. 2015, 5, 1519–1530.
  82. “A double bond-conjugated dimethylnitrobenzene-type photolabile nitric oxide donor with improved two-photon cross section” Naoya Ieda, Kazuhiro Hishikawa, Kei Eto, Kai Kitamura, Satoru Mori, Mayaka Maeno, Mitsuyasu Kawaguchi, Takayoshi Suzuki, Kiyoshi Fukuhara, Naoki Miyata, Toshiaki Furuta, Jun-ichi Nabekura, Hidehiko Nakagawa. Bioorg. Med. Chem. Lett. 2015, 25, 3172–3175.
  83. “Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukemia cells” Tomohiro Kozako, Takayoshi Suzuki, Makoto Yoshimitsu, Yuichiro Uchida, Ayako Kuroki, Akiyoshi Aikawa, Shin-ichiro Honda, Naomichi Arima, Shinji Soeda. Sci. Rep. 2015, 5, 11345.
  84. “Enrichment of O-GlcNAc-modified peptides using novel thiol-alkyne and thiol-disulfide exchange” Hiroki Tsumoto, Daisuke Ogasawara, Noritaka Hashii, Takayoshi Suzuki, Yoshihiro Akimoto, Tamao Endo, Yuri Miura. Bioorg. Med. Chem. Lett. 2015, 25, 2645–2649.
  85. “Identification of Jumonji AT-rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells” Yukihiro Itoh, Hideyuki Sawada, Miki Suzuki, Toshifumi Tojo, Ryuzo Sasaki, Makoto Hasegawa, Tamio Mizukami, and Takayoshi Suzuki. ACS Med. Chem. Lett. 2015, 6, 665–670.
  86. “Novelrole of PELP1 in regulating chemotherapy response in mutant p53-expressing triple negative breast cancercells.” Samaya R. Krishnan, Binoj C. Nair, Gangadhara R. Sareddy, Sudipa Saha Roy, Mohan Natarajan, Takayoshi Suzuki, Yan Peng, Ganesh Raj, Ratna K. Vadlamudi. Breast Cancer  Res. Treat. 2015, 150, 487–499.
  87. “Histone H3 peptide based LSD1-selective inhibitors” Taeko Kakizawa, Yosuke Ota, Yukihiro Itoh, Hiroki Tsumoto and Takayoshi Suzuki. Bioorg. Med. Chem. Lett. 2015, 25, 1925–1928.
  88. “NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect“Toshiki Etani, Takayoshi Suzuki, Taku Naiki, Aya Naiki-Ito, Ryosuke Ando, Keitaro Iida, Noriyasu Kawai, Keiichi Tozawa, Naoki Miyata, Kenjiro Kohri, Satoru Takahashi. Oncotarget 2015, 6, 2865–2878.
  89. “Design, synthesis, and biological activity of N-alkylated analogue of NCL1, a selective inhibitor of lysine-specific demethylase 1” Mohammed Naseer Ahmed Khan, Hiroki Tsumoto, Yukihiro Itoh, Yosuke Ota, Miki Suzuki, Daisuke Ogasawara, Hidehiko Nakagawa, Tamio Mizukami, Naoki Miyata and Takayoshi Suzuki. MedChemComm 2015, 6, 407–412.
  90. “Stereodivergent Synthesis of Arylcyclopropylamines by Sequential C-H Borylation and Suzuki-Miyaura Coupling” Shin Miyamura, Misaho Araki, Takayoshi Suzuki, Junichiro Yamaguchi, and Kenichiro Itami. Angew. Chem. Int. Ed. 2015, 54, 846–851.
  91. “Binding Thermodynamics of Structurally Similar Ligands to Histone Deacetylase 8 Sheds Light on Challenges in Rational Design of Potent and Isozyme-selective Inhibitors of the Enzyme” Raushan K. Singh, Takayoshi Suzuki, Tanmay Mandal, Narayanaganesh Balsubramanian, Manas Haldar, Dustin J. Mueller, Jerrod A. Strode, Gregory Cook, Sanku Mallik, and D. K.Srivastava. Biochemistry 2014, 53, 7445–7458.
  92. “Visible light-induced nitric oxide release from a novel nitrobenzene derivative cross-conjugated with a coumarin fluorophore” Kai Kitamura, Naoya Ieda, Kazuhiro Hishikawa, Takayoshi Suzuki, Naoki Miyata, Kiyoshi Fukuhara and Hidehiko Nakagawa. Bioorg. Med. Chem. Lett. 2014, 24, 5660–5662.
  93. “Differential effect of HDAC3 on cytoplasmic and nuclear Huntingtin aggregates” Tatsuo Mano, Takayoshi Suzuki, Shoji Tsuji, Atsushi Iwata. PLoS ONE 2014, 9, e111277.
  94. “Downregulation of Ca2+-activated Cl–channel TMEM16A by the inhibition of histone deacetylase in TMEM16A-expressing cancer cells” Sayo Matsuba, Satomi Niwa, Katsuhiko Muraki, Saki Kanatsuka, Yurika Nakazono, Noriyuki Hatano, Masanori Fujii, Peng Zhan, Takayoshi Suzuki, and Susumu Ohya. J. Pharmacol. Exp. Ther. 2014, 351, 510–518.
  95. “Histone Deacetylase Inhibitor Valproic Acid Promotes the Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-Like Cells” Yuki Kondo, Takahiro Iwao, Sachimi Yoshihashi, Kayo Mimori, Ruri Ogihara, Kiyoshi Nagata, Kouichi Kurose, Masayoshi Saito, Takuro Niwa, Takayoshi Suzuki, Naoki Miyata, Shigeru Ohmori, Katsunori Nakamura, Tamihide Matsunaga. PLoS ONE 2014, 9, e104010.
  96. “Identification of novel SIRT2-selective inhibitors using a click chemistry approach” Prima R. Tatum, Hideyuki Sawada, Yosuke Ota, Yukihiro Itoh, Peng Zhan, Naoya Ieda, Hidehiko Nakagawa, Naoki Miyata and Takayoshi Suzuki. Bioorg. Med. Chem. Lett. 2014, 24, 1871–1874.
  97. “Late-Stage C–H Coupling Enables Rapid Identification of HDAC Inhibitors: Synthesis and Evaluation of NCH-31 Analogues” Hiromi Sekizawa, Kazuma Amaike, Yukihiro Itoh, Takayoshi Suzuki, Kenichiro Itami, and Junichiro Yamaguchi. ACS Med. Chem. Lett. 2014, 5, 582–586.
  98. “Synthesis, LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugates” Yukihiro Itoh, Daisuke Ogasawara, Yosuke Ota, Tamio Mizukami, and Takayoshi Suzuki. Comput. Struct. Biotechnol. J. 2014, 9, e201402002.
  99.  “The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1” Andrew Tee, Dora Ling, Charlotte Nelson, Bernard Atmadibrata, Marcel Dinger, Ning Xu, Tamio Mizukami, Pei Y. Liu, Bing Liu, Belamy Cheung, Eddy Pasquier, Michelle Haber, Murray D. Norris, Takayoshi Suzuki, Glenn M. Marshall, and Tao Liu. Oncotarget 2014, 5, 1793–1804.
  100. “Regulation of Tissue Factor Pathway Inhibitor-2 (TFPI-2) Expression by Lysine-Specific Demethylase 1 and 2 (LSD1 and LSD2)” Koshiki Mino, Satoshi Nishimura, Shogo Ninomiya, Hiroshi Tujii, Yasumasa Matsumori, Mie Tsuchida, Miho Hosoi, Koichi Koseki, Shuichi Wada, Makoto Hasegawa, Ryuzo Sasaki, Yukie Murakami-Yamaguchi, Hiroshi Narita, Takayoshi Suzuki, Naoki Miyata, and Tamio Mizukami. Biosci. Biotech. Bioch. 2014, 78, 1010–1017.
  101. “Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylase 8-selective inhibitors” Takayoshi Suzuki,* Nobusuke Muto, Masashige Bando, Yukihiro Itoh, Ayako Masaki, Masaki Ri, Yosuke Ota, Hidehiko Nakagawa, Shinsuke Iida, Katsuhiko Shirahige, and Naoki Miyata. ChemMedChem 2014, 9, 657–664.
  102. “Photocontrollable Hydrogen Sulfide Donor using Ketoprofenate Photocages” Naoki Fukushima, Naoya Ieda, Kiyoshi Sasakura, Tetsuo Nagano, Kenjiro Hanaoka, Takayoshi Suzuki, Naoki Miyata and Hidehiko Nakagawa. Chem. Commun. 2014, 50, 587–589.
  103. “Fine spatiotemporal control of nitric oxide release by infrared pulse-laser irradiation of a photo-labile donor” Hidehiko Nakagawa, Kazuhiro Hishikawa, Kei Eto,  Naoya Ieda, Tomotaka Namikawa,  Kenji Kamada,  Takayoshi Suzuki, Naoki Miyata,  Junichi Nabekura. ACS Chem. Biol. 2013, 8, 2493–2500.
  104. “Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity” Takayoshi Suzuki, Hiroki Ozasa, Yukihiro Itoh, Peng Zhan, Hideyuki Sawada, Koshiki Mino, Louise Walport, Rei Ohkubo,　Akane Kawamura, Masato Yonezawa, Yuichi Tsukada, Anthony Tumber, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Christopher J. Schofield, and Naoki Miyata. J. Med. Chem. 2013, 56, 7222–7231.
  105. “A Reductant-Resistant and Metal-Free Fluorescent Probe for Nitroxyl Applicable to Living Cells” Kodai Kawai, Naoya Ieda, Kazuyuki Aizawa, Takayoshi Suzuki, Naoki Miyata, and Hidehiko Nakagawa. J. Am. Chem. Soc. 2013, 135, 12690–12696.
  106. “Search for a Novel SIRT1 Activator: Structural Modification of SRT1720 and Biological Evaluation” Yuji Matsuya, Yuta Kobayashi, Sayumi Uchida, Yukihiro Itoh, Hideyuki Sawada, Takayoshi Suzuki, Naoki Miyata, Kenji Sugimoto, Naoki Toyooka. Bioorg. Med. Chem. Lett. 2013, 23, 4907–4910.
  107. “Lysine-Specific Demethylase 1-Selective Inactivators: Protein-Targeted Drug Delivery Mechanism“ Daisuke Ogasawara, Yukihiro Itoh, Hiroki Tsumoto, Taeko Kakizawa, Koshiki Mino, Kiyoshi Fukuhara, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata, and Takayoshi Suzuki. Angew. Chem. Int. Ed. 2013, 52, 8620–8624.
  108. “Identification of Highly Selective and Potent Histone Deacetylase 3 Inhibitors Using Click Chemistry-Based Combinatorial Fragment Assembly” Takayoshi Suzuki, Yuki Kasuya, Yukihiro Itoh, Yosuke Ota, Peng Zhan, Kaori Asamitsu, Hidehiko Nakagawa, Takashi Okamoto, and Naoki Miyata. PLoS ONE 2013, 8, e68669.
  109. “Lysin-specific histone demethylase 1 (LSD1/KDM1A) qualifies as promising new epigenetic therapy target in medulloblastoma” Kristian W. Pajtler, Christina Weingarten, Theresa Thor, Annette Kuenkele, Lukas C. Heukamp, Reinhard Büttner, Takayoshi Suzuki, Naoki Miyata, Michael Grotzer, Anja Rieb, Annika Sprüssel, Angelika Eggert, Alexander Schramm, and Johannes H. Schulte. Acta Neuropathologica Communications 2013, 1, 19.
  110. “Piloty’s acid derivative with improved nitroxyl-releasing characteristics” Kazuyuki Aizawa, Hidehiko Nakagawa, Kazuya Matsuo, Kodai Kawai, Naoya Ieda, Takayoshi Suzuki, and Naoki Miyata. Bioorg. Med. Chem. Lett. 2013, 23, 2340–2343.
  111. “KDM1 is a novel therapeutic target for the treatment of gliomas” Gangadhara R Sareddy, Binoj C. Nair, Samaya K Krishnan, Vijaya Gonugunta, Quan-guang Zhang, Takayoshi Suzuki, Naoki Miyata, Andrew Brenner, Darrell W. Brann, and Ratna K. Vadlamudi. Oncotarget 2013, 4, 18–28.
  112. “FFA1-selective agonistic activity based on docking simulation using FFA1 and GPR120 homology models” Masato Takeuchi, Akira Hirasawa, Takafumi Hara, Ikuo Kimura, Tatsuya Hirano, Takayoshi Suzuki, Naoki Miyata, Takeo Awaji, Masaji Ishiguro, and Gozoh Tsujimoto. J. Pharmacol. 2013, 168, 1570–1583.
  113. “Rapid Discovery of Highly Potent and Selective Inhibitors of Histone Deacetylase 8 Using Click Chemistry to Generate Candidate Libraries” Takayoshi Suzuki, Yosuke Ota, Masaki Ri, Masashige Bando, Aogu Gotoh, Yukihiro Itoh, Hiroki Tsumoto, Prima R. Tatum, Tamio Mizukami, Hidehiko Nakagawa, Shinsuke Iida, Ryuzo Ueda, Katsuhiko Shirahige, and Naoki Miyata. J. Med. Chem. 2012, 55, 9562–9575.
  114. “Photoinduced Upregulation of Calcitonin Gene-Related Peptide in A549 Cells through HNO Release from a Hydrophilic Photocontrollable HNO Donor” Kazuya Matsuo, Hidehiko Nakagawa, Yusuke Adachi, Eri Kameda, Kazuyuki Aizawa, Hiroki Tsumoto, Takayoshi Suzuki, and Naoki Miyata. Chem. Pharm. Bull. 2012, 60, 1055–1062.
  115. “Targeting PELP1-KDM1 axis as a potential therapeutic strategy for breast cancer” Valerie Cortez, Monica Mann, Seshidhar Tekmal, Takayoshi Suzuki, Naoki Miyata, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Anil K Sood, and Ratna K Vadlamudi. Breast Cancer Res. 2012, 14, R108.
  116. “Design, Synthesis, and Biological Activity of a Novel Series of Human Sirtuin 2-selective Inhibitors” Takayoshi Suzuki, Mohammed Naseer Ahmed Khan, Hideyuki Sawada, Erika Imai, Yukihiro Itoh, Katsura Yamatsuta, Natsuko Tokuda, Jun Takeuchi, Takuya Seko, Hidehiko Nakagawa, and Naoki Miyata. J. Med. Chem. 2012, 55, 5760–5773.
  117. “Novel bisbenzimide-nitroxides for nuclear redox imaging in living cells” Mamiko Ikeda, Hidehiko Nakagawa, Takayoshi Suzuki and Naoki Miyata. Bioorg. Med. Chem. Lett. 2012, 22, 1949–1952.
  118. “Photo-controllable Peroxynitrite Generator Based on N-Methyl-N-nitrosoaminophenol for Cellular Application” Naoya Ieda, Hidehiko Nakagawa, Tao Peng, Dan Yang, Takayoshi Suzuki and Naoki Miyata. J. Am. Chem. Soc. 2012, 134, 2563–2568.
  119. “Loss of Deacetylation Activity of Hdac6 Affects Emotional Behavior in Mice” Masahide Fukada, Atsuko Hanai, Atsuo Nakayama, Takayoshi Suzuki, Naoki Miyata, Romana M. Rodriguiz, William C. Wetsel, Tso-Pang Yao and Yoshiharu Kawaguchi. PLoS ONE 2012, 7, e30924.
  120. “Peroxynitrite Generation from NO-releasing Nitrobenzene Derivative in Response to Photoirradiation” Naoya Ieda, Hidehiko Nakagawa, Taeko Horinouchi, Tao Peng, Dan Yang, Hiroki Tsumoto, Takayoshi Suzuki, Kiyoshi Fukuhara and Naoki Miyata. Chem. Commun. 2011, 47, 6449–6451.
  121. “Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression” Ann Florence B Victoriano, Kenichi Imai, Hiroaki Togami, Takaharu Ueno, Kaori Asamitsu, Takayoshi Suzuki, Naoki Miyata, Kuniyasu Ochiai and Takashi Okamoto. FEBS Lett. 2011, 585,1103–1111.
  122. “A novel mitochondria-localizing nitrobenzene derivative as a donor for photo-uncaging of nitric oxide” Taeko Horinouchi, Hidehiko Nakagawa, Takayoshi Suzuki, Kiyoshi Fukuhara and Naoki Miyata. Bioorg. Med. Chem. Lett. 2011, 21, 2000–2002.
  123. “Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor” Daisuke Ogasawara, Takayoshi Suzuki, Koshiki Mino, Rie Ueda, Mohammed Naseer Ahmed Khan, Takuya Matsubara, Koichi Koseki, Makoto Hasegawa, Ryuzo Sasaki, Hidehiko Nakagawa, Tamio Mizukami and Naoki Miyata. Bioorg. Med. Chem. 2011, 19, 3702–3708.
  124. “Photoinduced nitric oxide release in mitochondria from a nitrobenzene derivative” Taeko Horinouchi, Hidehiko Nakagawa, Takayoshi Suzuki, Kiyoshi Fukuhara and Naoki Miyata. Chem. Eur. J. 2011, 4809–4813.
  125. “Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events” Shusaku Uchida, Kumiko Hara, Ayumi Kobayashi, Koji Otsuki, Hirotaka Yamagata, Teruyuki Hobara, Takayoshi Suzuki, Naoki Miyata, and Yoshifumi Watanabe. Neuron 2011, 69, 359–372.
  126. “Development of a DNA-binding TEMPO derivative for evaluation of nuclear oxidative stress and its application in living cells” Mamiko Ikeda, Hidehiko Nakagawa, Shizuka Ban, Hiroki Tsumoto, Takayoshi Suzuki and Naoki Miyata. Free Radical Biol. Med. 2010, 49, 1792–1797.
  127. “Structure-activity relationships of GPR120 agonists based on a docking simulation”Qi Sun, Akira Hirasawa, Takafumi Hara, Ikuo Kimura, Tetsuya Adachi, Takeo Awaji, Masaji Ishiguro, Takayoshi Suzuki, Naoki Miyata and Gozoh Tsujimoto. Pharmacol. 2010, 78, 804–810.
  128. “Design, Synthesis, Enzyme-inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors” Shohei Hamada, Takayoshi Suzuki,* Koshiki Mino, Koichi Koseki, Felix Oehme, Ingo Flamme, Hiroki Ozasa, Yukihiro Itoh, Daisuke Ogasawara, Haruka Komaarashi, Aiko Kato, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami and Naoki Miyata. J. Med. Chem. 2010, 53, 5629–5638.
    Most Read Article (Sep. 2010)
  129. “An Unexpected Example of Protein-Templated Click Chemistry” Takayoshi Suzuki,* Yosuke Ota, Yuki Kasuya, Motoh Mutsuga, Yoko Kawamura, Hiroki Tsumoto, Hidehiko Nakagawa, M. G. Finn, and Naoki Miyata. Angew. Chem. Int. Ed. 2010, 49, 6817–6820.
  130. “Alternative photoinduced release of HNO or NO from an acyl nitroso compound, depending on environmental polarity” Kazuya Matsuo, Hidehiko Nakagawa, Yusuke Adachi, Eri Kameda, Hiroki Tsumoto, Takayoshi Suzuki and Naoki Miyata. Chem. Commun. 2010, 46, 3788–3790.
  131. “Syntheses of water-soluble [60]fullerene derivatives and their enhancing effect on neurite outgrowth in NGF-treated PC12 cells” Hiroki Tsumoto, Syo Kawahara, Yuki Fujisawa, Takayoshi Suzuki, Hidehiko Nakagawa, Kohfuku Kohda and Naoki Miyata. Bioorg. Med. Chem. Lett. 2010, 20, 1948–1952.
  132. “Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors” Takayoshi Suzuki,* Rikako Tanaka, Shohei Hamada, Hidehiko Nakagawa and Naoki Miyata. Bioorg. Med. Chem. Lett. 2010, 20, 1124–1127.
  133. “Multiple Bond-Conjugated Photoinduced Nitric Oxide Releaser Based on Acceptor-Donor-Acceptor Structure Working with Two-Photon Excitation” Kazuhiro Hishikawa, Toshiaki Furuta, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki and Naoki Miyata. Bioorg. Med. Chem. Lett. 2010, 20, 302–305.
  134. “Identification of cell-active lysine specific demethylase 1-selective inhibitors” Rie Ueda, Takayoshi Suzuki,* Koshiki Mino, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, and Naoki Miyata. J. Am. Chem. Soc. 2009, 131, 17536–17537.
    Highlighted in SciBX (Biocentury and Nature) 2009, 2,     1683.
  135. “Identification of a non-peptide sirtuin inhibitor containing N-thioacetyl lysine” Takayoshi Suzuki,* Tomomi Asaba, Erika Imai, Hiroki Tsumoto, Hidehiko Nakagawa and Naoki Miyata.* Bioorg. Med. Chem. Lett. 2009, 19, 5670–5672.
  136. “Design, synthesis, enzyme inhibition and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors” Takayoshi Suzuki,* Keiko Imai, Erika Imai, Shinsuke Iida, Ryuzo Ueda, Hiroki Tsumoto, Hidehiko Nakagawa and Naoki Miyata.* Bioorg. Med. Chem. 2009, 17, 5900–5905.
  137. “Photoinduced Nitric Oxide Release from a Hindered Nitrobenzene Derivative by Two-Photon Excitation” Kazuhiro Hishikawa, Hidehiko Nakagawa, Toshiaki Furuta, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki, and Naoki Miyata. J. Am. Chem. Soc. 2009, 131, 7488–7489.
  138. “Inhibition of Human Sirtuins by In Situ Generation of an Acetylated Lysine-ADP-ribose Conjugate” Tomomi Asaba, Takayoshi Suzuki,* Rie Ueda, Hiroki Tsumoto, Hidehiko Nakagawa, and Naoki Miyata. J. Am. Chem. Soc. 2009, 131, 6989–6996.
  139. “Design, Synthesis, and Biological Activity of Boronic acid-Based Histone Deacetylase Inhibitors” Nobuaki Suzuki, Takayoshi Suzuki,* Yosuke Ota, Tatsuya Nakano, Masaaki Kurihara, Haruhiro Okuda, Takao Yamori, Hiroki Tsumoto, Hidehiko Nakagawa, and Naoki Miyata. J. Med. Chem. 2009, 52, 2909–2922.
    Highlighted in SciBX (Biocentury a    nd Nature) 2009, 2, 12.
  140. “Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors” Shohei Hamada, Tae-Dong Kim, Takayoshi Suzuki,* Yukihiro Itoh, Hiroki Tsumoto, Hidehiko Nakagawa, Ralf Janknecht*and Naoki Miyata.* Bioorg. Med. Chem. Lett. 2009, 19, 2852–2855.
  141. “Identification of G protein-coupled receptor 120-selective agonists derived from PPARg agonists” Takayoshi Suzuki, Sou-ichi Igari, Akira Hirasawa, Mie Hata, Masaji Ishiguro, Hiroki Fujieda, Yukihiro Itoh, Tatsuya Hirano, Hidehiko Nakagawa, Michitaka Ogura, Makoto Makishima, Gozoh Tsujimoto and Naoki Miyata. J. Med. Chem. 2008, 51, 7640–7644.
  142. “Microtuble Acetylation Through HDAC6 Inhibition Results in Increased Transfection Efficiency” Erin E. Vaughan, R. Christopher Geiger, Aaron M. Miller, Takayoshi Suzuki, Naoki Miyata and David A. Dean. Mol. Ther. 2008, 16, 1841–1847.
  143. “Photoactivatable HNO-releasing Compounds Using the retro-Diels-Alder Reaction” Yusuke Adachi, Hidehiko Nakagawa, Kazuya Matsuo, Takayoshi Suzuki and Naoki Miyata. Chem. Commun. 2008, 5149–5151.
  144. “Preparation of C60-based active esters and coupling of C60 moiety to amines or alcohols” Hiroki Tsumoto, Katsumasa Takahashi, Takayoshi Suzuki, Hidehiko Nakagawa, Kohfuku Kohda and Naoki Miyata. Bioorg. Med. Chem. Lett. 2008, 18, 657–660.
  145. “Design, Synthesis, Structure-Selectivity Relationship, and Effect on Human Cancer Cells of a Novel Series of Histone Deacetylase 6-Selective Inhibitors” Yukihiro Itoh, Takayoshi Suzuki,* Akiyasu Kouketsu, Nobuaki Suzuki, Satoko Maeda, Minoru Yoshida, Hidehiko Nakagawa and Naoki Miyata. J. Med. Chem. 2007, 50, 5425–5438.
    Most Accessed Article
  146. “A new series of anti-prion compounds; pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation” Ayako Kimata, Hidehiko Nakagawa, Ryo Ohyama, Tomoko Fukuuchi, Shigeru Ohta, Katsumi Doh-ura, Takayoshi Suzuki and Naoki Miyata. J. Med. Chem. 2007, 50, 5053–5056.
  147. “Design, Synthesis and Biological Activity of Folate Receptor-targeted Prodrugs of Thiolate Histone Deacetylase Inhibitors” Takayoshi Suzuki,* Shinya Hisakawa, Yukihiro Itoh, Nobuaki Suzuki, Katsumasa Takahashi, Masatoshi Kawahata, Kentaro Yamaguchi, Hidehiko Nakagawa and Naoki Miyata. Bioorg. Med. Chem. Lett. 2007, 17, 4208–4212.
  148. “Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cell” Takaomi Sanda, Takashi Okamoto, Yuto Uchida, Hidehiko Nakagawa, Shinsuke Iida, Satoshi Kayukawa, Takayoshi Suzuki, Tadashi Oshizawa, Takayoshi Suzuki, Naoki Miyata and Ryuzo Ueda. Leukemia 2007, 21, 2344–2353.
  149. “Synthesis and biological evaluation of 2-nonylaminopyridine derivatives as PPAR ligands” Shinya Usui, Hiroki Fujieda, Takayoshi Suzuki, Naoaki Yoshida, Hidehiko Nakagawa, Michitaka Ogura, Makoto Makishima, and Naoki Miyata. Chem. Pharm. Bull. 2007, 55, 1053–1059.
  150. “Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARd-selective agonists” Hiroki Fujieda, Shinya Usui, Takayoshi Suzuki, Hidehiko Nakagawa, Michitaka Ogura, Makoto Makishima, and Naoki Miyata. Bioorg. Med. Chem. Lett. 2007, 17, 4351–4357.
  151. “Novel mitochondria-localizing TEMPO derivative for measurement of cellular oxidative stress in mitochondria” Shizuka Ban, Hidehiko Nakagawa, Takayoshi Suzuki and Naoki Miyata. Bioorg. Med. Chem. Lett. 2007, 17, 2055–2058.
  152. “Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor” Takayoshi Suzuki,* Shinya Hisakawa, Yukihiro Itoh, Sakiko Maruyama, Mineko Kurotaki, Hidehiko Nakagawa and Naoki Miyata. Bioorg. Med. Chem. Lett. 2007, 17, 1558–1561.
  153. “Novel membrane-localizing TEMPO derivatives for measurement of cellular oxidative stress at the cell membrane” Shizuka Ban, Hidehiko Nakagawa, Takayoshi Suzuki and Naoki Miyata. Bioorg. Med. Chem. Lett. 2007, 17, 1451–1454.
  154. “Hydroxyl radical scavenging by edaravone derivatives: Efficient scavenging by 3- methyl-1-(pyridin-2-yl)-5-pyrazolone with an intramolecular base” Hidehiko Nakagawa, Ryo Ohyama, Ayako Kimata, Takayoshi Suzuki and Naoki Miyata. Bioorg. Med. Chem. Lett. 2006, 16, 5939–5942.
  155. “2-Anilinobenzamides as SIRT inhibitors” Takayoshi Suzuki,* Keiko Imai, Hidehiko Nakagawa and Naoki Miyata. ChemMedChem 2006, 1, 1059–1062.
    cover picture
  156. “Highly Potent and Selective Histone Deacetylase 6 Inhibitors Desigened Based on a Small-molecular Substrate” Takayoshi Suzuki,* Akiyasu Kouketsu, Shinya Hisakawa, Yukihiro Itoh, Satoko Maeda, Minoru Yoshida, Hidehiko Nakagawa and Naoki Miyata. J. Med. Chem. 2006, 49, 4809–4812.
    Most Accessed Article
  157. “Benzimidazole Derivatives Bearing Substituted Biphenyls as Hepatitis C Virus NS5B RNA-dependent RNA Polymerase Inhibitors: Structure-Activity Relationship Studies and Identification of a Potent and Highly Selective HCV NS5B Inhibitor JTK-109” Shintaro Hirashima, Takayoshi Suzuki,* Tomio Ishida, Satoru Noji, Shinji Yata, Izuru Ando, Masakazu Komatsu, Satoru Ikeda and Hiromasa Hashimoto. J. Med. Chem. 2006, 49, 4721–4736.
  158. “Identification of novel PPARa ligands by the structural modification of a PPARg ligand” Shinya Usui, Hiroki Fujieda, Takayoshi Suzuki, Naoaki Yoshida, Hidehiko Nakagawa and Naoki Miyata. Bioorg. Med. Chem. Lett. 2006, 16, 3249–3254.
  159. “Benzimidazole Inhibitors of Hepatitis C Virus NS5B Polymerase: Identification of 2-[(4-Diarylmethoxy)phenyl]benzimidazole” Tomio Ishida, Takayoshi Suzuki, Shintaro Hirashima, Kenji Mizutani, Atsuhito Yoshida, Izuru Ando, Satoru Ikeda, and Hiromasa Hashimoto. Bioorg. Med. Chem. Lett. 2006, 16, 1859–1863.
    Most Cited Paper 2006-2009 Award
  160. “Novel Human Histone Deacetylase Inhibitors: Design, Synthesis, Enzyme Inhibition, and Cancer Cell Growth Inhibition of SAHA-Based Non-hydroxamates” Takayoshi Suzuki,* Yuki Nagano, Akiyasu Kouketsu, Azusa Matsuura, Sakiko Maruyama, Mineko Kurotaki, Hidehiko Nakagawa, and Naoki Miyata. J. Med. Chem. 2005, 48, 1019–1032.
  161. “Identification of a potent non-hydroxamate histone deacetylase inhibitor by mechanism-based drug design” Takayoshi Suzuki,* Azusa Matsuura, Akiyasu Kouketsu, Hidehiko Nakagawa, and Naoki Miyata. Bioorg. Med. Chem. Lett. 2005, 15, 331–335.
    Most Cited Paper 2005-2008 Award
  162. “Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent” Takayoshi Suzuki,* Azusa Matsuura, Akiyasu Kouketsu, Shinya Hisakawa, Hidehiko Nakagawa and Naoki Miyata. Bioorg. Med. Chem. 2005, 13, 4332–4342.
    Most downloaded Article
  163. “Phtoinduced Nitric Oxide Release from Nitrobenzene Derivatives” Takayoshi Suzuki, Osamu Nagae, Yuka Kato, Hidehiko Nakagawa, Kiyoshi Fukuhara, and Naoki Miyata. J. Am. Chem. Soc. 2005, 127, 11720–11726.
  164. “Design, synthesis and biological activity of novel PPARg ligands based on rosiglitazone and 15d-PGJ2” Shinya Usui, Takayoshi Suzuki, Yoshifumi Hattori, Kazuma Etoh, Hiroki Fujieda, Makoto Nishizuka, Masayoshi Imagawa, Hidehiko Nakagawa, Kohfuku Kohda, and Naoki Miyata. Bioorg. Med. Chem. Lett. 2005, 15, 1547–1551.
  165. “Thiol-based SAHA analogues as potent histone deacetylase inhibitors” Takayoshi Suzuki,* Akiyasu Kouketsu, Azusa Matsuura, Arihiro Kohara, Shin-ichi Ninomiya, Kohfuku Kohda, and Naoki Miyata. Bioorg. Med. Chem. Lett. 2004, 14, 3313–3317.
  166. “Novel Histone Deacetylase Inhibitors: Design, Synthesis, Enzyme Inhibition, and Binding Mode Study of SAHA-Based Non-hydroxamates” Takayoshi Suzuki, Yuki Nagano, Azusa Matsuura, Arihiro Kohara, Shin-ichi Ninomiya, Kohfuku Kohda, and Naoki Miyata. Bioorg. Med. Chem. Lett. 2003, 13, 4321–4326.
  167. “Superacid-Catalyzed Electrocyclization of Diphenylmethyl Cations to Fluorenes. Kinetic and Theoretical Revisit Supporting the Involvement of Ethylene Dications” Tomohiko Ohwada, Takayoshi Suzuki, and Koichi Shudo. J. Am. Chem. Soc. 1998, 120, 4629–4637.
  168. “Superacid-Catalyzed Electrocyclization of 1-Phenyl-2-propen-1-ones to 1-Indanones. Kinetic and Theoretical Studies of Electrocyclization of Oxonium-Carbenium Dications” Takayoshi Suzuki, Tomohiko Ohwada, and Koichi Shudo. J. Am. Chem. Soc. 1997, 119, 6774–6780.
  169. “Structures and Reactivities of Ethylene Dication Electrophiles” Tomohiko Ohwada, Takahisa Yamazaki, Takayoshi Suzuki, Shinichi Saito, and Koichi Shudo. J. Am. Chem. Soc. 1996, 118, 6220–6224.
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