大阪大学　産業科学研究所　精密制御化学　中谷研究室

中谷　和彦

堂野　主税

村田　亜沙子

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准教授　村田　亜沙子
むらた　あさこ

amulata@ sanken.osaka-u.ac.jp

学　　歴
平成１３年３月　筑波大学第二学群生物学類卒業
平成１５年３月　東京大学大学院新領域創成科学研究科先端生命科学専攻　修士課程修了（西郷和彦教授）
平成１８年３月　東京大学大学院新領域創成科学研究科メディカルゲノム専攻博士課程修了 (西郷和彦教授）

職　　歴
平成１８年６月　米国ベイラー医科大学生化学・分子生物学科　博士研究員（上杉志成教授）
平成２０年3月　京都大学化学研究所　特任研究員（上杉志成教授）
平成２２年3月　京都大学物質－細胞統合システム拠点　研究員（上杉志成教授）
平成２２年6月　大阪大学産業科学研究所　特任研究員（中谷和彦教授）
平成２４年１２月　大阪大学産業科学研究所　助教（中谷和彦教授）
令和１年１２月　大阪大学産業科学研究所　准教授（中谷和彦教授）

論文リスト

Original Papers

(30) Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model, Ni, L., Yamada, Y.; Murata, A.; Nakatani, K. Chem. Commun. in press.

(29) 2-Amino-1,8-naphthyridine dimer (ANP77), a high affinity binder to the internal loops of C/CC and T/CC sites in double-stranded DNA, Das, B.; Nagano, K.; Kawai, G.; Murata, A.; Nakatani, K. J. Org. Chem. 2022, 87, 340-350. doi.org/10.1021/acs.joc.1c02383.

(28) HT-SELEX based identification of binding pre-miRNA hairpin-motif for small molecule, Mukherjee, S.; Murata, A.; Ishida, R.; Sugai, A.; Dohno, C.; Hamada, M.; Krishna, S.; Nakatani, K. Mol. Ther. Nucleic Acids 2022, 27, 165-174. doi.org/10.1016/j.omtn.2021.11.021.

(27) A small-molecule fluorescence probe ANP77 for sensing RNA internal loop of C, U, and A/CC motifs and their binding molecules, Das, B.; Murata, A.; Nakatani, K. Nucleic Acids Res. 2021,49, 8462-8470. doi.org/10.1093/nar/gkab650.

(26) Speeding drug discovery targeting RNAs: an iterative "RNA selection-compounds screening cycle" for exploring RNA-small molecule pairs, Furuzono, T.; Murata, A.; Okuda, S.; Mizutani, K.; Adachi, T.; Nakatani, K. Bioorg. Med. Chem. 2021, 36, 16070-16076. doi.org/10.1016/j.bmc.2021.116070.

(25) Small molecule-induced dimerization of hairpin RNA interfered with the Dicer cleavage reaction, Murata, A.; Mori, Y.; Di, Y.; Sugai, A.; Das, B.; Takashima, Y.; Nakatani, K. Biochemistry 2021, 60, 245-249. doi.org/10.1021/acs.biochem.0c00920.

(24) The dimeric form of 1,3‐diaminoisoquinoline derivative rescued the mis‐splicing of Atp2a1 and Clcn1 genes in myotonic dystrophy type 1 mouse model, Matsumoto, J.; Nakamori, M.; Okamoto, T.; Murata, A.; Dohno, C.; Nakatani, K. Chem. Eur. J. 2020, 26, 14305-14309. doi: 10.1002/chem.202001572.

(23) Slipped-CAG DNA binding small molecule induces trinucleotide repeat contractions in vivo, Nakamori, M.; Panigrahi, G. B.; Lanni, S.; Gall-Duncan, T.; Hayakawa, H.; Tanaka, H.; Luo, J.; Otabe, T.; Li, J.; Sakata, A.; Caron, M. C.; Joshi, N.; Prasolava, T.; Chiang, K.; Masson, J. Y.; Wold, M. S.; Wang, X.; Lee, M.; Huddleston, J.; Munson, K. M.; Davidson, S.; Layeghifard, M.; Edward, L. M.; Gallon, R.; Santibanez-Koref, M.; Murata, A.; Takahashi, M. P.; Eichler, E. E.; Shlien, A.; Nakatani, K.; Mochizuki, H.; Pearson, C. E. Nat. Genet. 2020, 52, 146-159. doi: 10.1038/s41588-019-0575-8.

(22) Structural insights into synthetic ligands targeting A－A pairs in disease-related CAG RNA repeats, Mukherjee, S.; Błaszczyk, L.; Rypniewski, W.; Falschlunger, C.; Micura, R.; Murata, A.; Dohno, C.; Nakatani, K.; Kiliszek, A. Nucl. Acids Res. 2019,47, 10906-10913. doi.org/10.1093/nar/gkz832.

(21) RT-Hpro-PCR: A MicroRNA Detection System Utilizing a Primerwith a DNA Tag. Takei, F.; Akiyama, M.; Murata, A.; Sugai, A.; Nakatani, K.; Yamashita, I. ChemBioChem 2020, 21, 477-480. doi: 10.1002/cbic.201900382.

(20) Modulating RNA secondary and tertiary structures by mismatch binding ligands. Murata, A.; Nakamori, M.; Nakatani, K. Methods 2019,167, 78-91. doi: 10.1016/j.ymeth.2019.05.006.

(19) Inhibition of pre-miRNA-136 processing by Dicer with small molecule BzDANP suggested the formation of ternary complex of pre-miR-136-BzDANP-Dicer. Otabe T.; Nagano K.; Kawai G.; Murata A.; Nakatani K. Bioorg. Med. Chem. 2019, 27, 2140-2148. doi: 10.1016/j.bmc.2019.03.031.

(18) A dimeric 2,9-diamino-1,10-phenanthroline derivative improves alternative splicing in myotonic dystrophy type 1 cell and mouse models. Li, J.; Nakamori, M.; Matsumoto, J.; Murata, A.; Dohno, C.; Kiliszek, A.; Taylor, K.; Sobczak, K.; Nakatani, K. Chem. Eur. J. 2018, 24, 18115-18122. 10.1002/chem.201804368.

(17) Small synthetic molecule-stabilized RNA pseudoknot as an activator for －1 ribosomal frameshifting, Matsumoto, S.; Caliskan, N.; Rodnina, M. V.; Murata, A.; Nakatani, K. Nucl. Acids Res. 2018, 46, 8079-8089. doi.org/10.1093/nar/gky689.

(16) Synthesis of naphthyridine dimers with conformational restriction and the binding to DNA and RNA, Nakatani, K.; Natsuhara, N.; Mori, Y.; Mukherjee, S.; Das, B.; and Murata, A. Chem. Asian J. 2017, 12, 3077-3087, doi: 10.1002/asia.201701293.

(15) Synthetic ligand promotes gene expression by affecting GC sequence in promoter, Matsumoto, S.; Iida, K.; Murata, A.; Denawa M.; Hagiwara, M.; Nakatani, K. Bioorg. Med. Chem. Lett. 2017, 27, 3391-3394, DOI: 10.1016/j.bmcl.2017.06.006.

(14) A Ligand that Targets CUG Trinucleotide Repeats, Li. J.; Matsumoto, J.; Bai, L.-P.; Murata, A.; Dohno, A.; Nakatani, K. Chem. Eur. J. 2016, 22, 14881-14889. doi: 10.1002/chem.201602741. selected as cover picture.

(13) BzDANP, a small-molecule modulator of pre-miR-29a maturation by Dicer, Murata, A.; Otabe, T.; Zhang, J.; Nakatani, K. ACS Chem. Biol. 2016, 11, 2790-2796. doi: 10.1021/acschembio.6b00214.

(12) Exploratory Study on the RNA-Binding Structural Motifs by Library Screening Targeting pre-miRNA-29a. Fukuzumi, T.; Murata, A.; Aikawa, H.; Harada, Y.: Nakatani, K. Chem. Eur. J. 2015, 21, 16859-16867. doi: 10.1002/chem.201502913. Very Important Paper.

(11) Synthesis of 8-substituted adenine and adenosine libraries and the binding to pre-miR-29a, Fukuzumi, T.; Aikawa, H.; Harada, Y.; Sugai, A.; Murata, A.; Nakatani, K. Bull. Chem. Soc. Jpn. 2014, 87, 1013-1015. doi: 10.1246/bcsj.20140137

(10) Formation of Ligand-Assisted Complex of Two RNA Hairpin Loops, Hong, C.; Otabe, T.; Matsumoto, S.; Dohno, C.; Murata, A.; Hagihara, M.; Nakatani, K. Chem. Eur. J. 2014, 20, 5282-5287. doi: 10.1002/chem.201304683.

(9) Fluorescent indicator displacement assay of ligands targeting 10 microRNA precursors. Murata, A.; Harada, Y.; Fukuzumi, T.; Nakatani, K. Bioorg. Med. Chem. 2013, 21, 7101-7106. doi: 10.1016/j.bmc.2013.09.007.

(8) Ligand-inducible formation of RNA pseudoknot. Matsumoto, S., Hong, C; Otabe, T.; Murata, A.; Nakatani, K. Bioorg. Med. Chem. Lett. 2013, 23, 3539-3541. doi: 10.1016/j.bmcl.2013.04.037.

(7) Xanthone derivatives as potential inhibitors of miRNA processing by human Dicer: Targeting secondary structures of pre-miRNA by small molecules. Murata, A.; Fukuzumi, T.; Umemoto, S.; Nakatani, K. Bioorg. Med. Chem. Lett. 2013, 23, 252-255.

(6) Structure-Activity Studies on the Fluorescent Indicator in the Displacement Assay for the Screening of Small Molecules Binding to RNA. Umemoto, S.; Im, S.; Zhang, J.; Hagihara, M.; Murata, A.; Harada, Y.; Fukuzumi, T.; Wazaki, T.; Sasaoka, S.; Nakatani, K. Chem. Eur. J. 2012, 18, 9999-10008.

(5) Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin. Sato, S.; Murata, A.; Orihara, T.; Shirakawa, T.; Suenaga, K.; Kigoshi, H.; Uesugi, M. Chem. Biol. 2011, 18, 131-139.

(4) Small-Molecule Fluorescent Probes for Specific RNA Targets. Murata, A.; Sato, S.; Kawazoe, Y.; Uesugi, M. Chem. Commun. 2011, 47, 4712-4714.

(3) Biochemical Target Isolation for Novices: Affinity-Based Strategies. Sato, S.; Murata, A.; Shirakawa, T.; Uesugi, M. Chem. Biol. 2010, 17, 616-623.

(2) Synthesis of a Novel Ester Analog of Nucleic Acids Bearing a Serine Backbone Murata, A.; Wada, T. Bioorg. Med. Chem. Lett. 2006, 16, 2933-2936.

(1) A Novel Linker for Solid-Phase Synthesis Cleavable under Neutral Conditions. Murata, A.; Wada, T. Tetrahedron Lett. 2006, 47, 2147-2150.

総説・著書など

（５）生理活性物質による創薬標的同定のコツ　佐藤慎一、村田亜沙子、白川貴詩、上杉志成、実験医学別冊　創薬研究のためのタンパク質・プロテオミクス解析、2010, 141-146.

（４）海洋天然物のケミカルジェネティクス　佐藤慎一、村田亜沙子、上杉志成、細胞工学　特集ケミカルジェネティクス、2009, 28, 332-337.

（３）iPS細胞作製を効率化する化合物　村田亜沙子、上杉志成、現代化学、2008, 452, 37-39.

（２）Identification of the Cardiac Beta-Adrenergic Receptor Protein: Solubilization and Purification by Affinity Chromatography　佐藤慎一、村田亜沙子、上杉志成、蛋白質核酸酵素、2007, 52, 1782-1783.

（１）生物医学研究を加速するケミカルゲノミクス　村田亜沙子、佐藤慎一、上杉志成、最新医学　臨床遺伝学’07、2007, 62, 2205-2213.

国際会議論文・Proceedingsなど

(2) Solid-Phase Synthesis of a Novel Polyester Analog of Nucleic Acid Bearing Serine Backbone Using a Linker Which Cleaved under Neutral Conditions. Murata, A.; Saigo, K.; Wada, T. Peptide Science 2005, 2005, 42, 109-102.

(1) Solid-Phase Synthesis of a Novel Polyester Analog of Nucleic Acid Bearing Serine Backbone. Wada, T.; Murata, A.; Tsuneyama, T.; Saigo, K. Peptide Science 2003, 2003, 40, 159-160.